Recent data obtained by pulsed-field gel electrophoresis suggest two types of double-strand breaks

Radiation Research

Volumn 149, Issue 1, 1998, Pages 52-58

  Radivoyevitch, Tomas ^a   Hoel, David G ^a   Hahnfeldt, Philip J ^b   Rydberg, Björn ^c   Sachs, Rainer K ^c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

ARTICLE; DNA HYBRIDIZATION; DNA METABOLISM; DNA REPAIR; DNA STRAND BREAKAGE; LINEAR ENERGY TRANSFER; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RADIATION DOSE; X RAY;

ANIMALS; DNA; DNA DAMAGE; DNA REPAIR; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; MODELS, STATISTICAL;

EID: 0031962472     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579681     Document Type: Article

References (24)

1. M. Löbrich, B. Rydberg and P. K. Cooper, Repair of X-ray induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: Joining of correct and incorrect ends. Proc. Natl. Acad. Sci. USA 92, 12050-12054 (1995).
2. T. Radivoyevitch, D. G. Hoel, A. M. Chen and R. K. Sachs, Misrejoining of double-strand breaks after X irradiation: Relating moderate to very high doses by a Markov model. Radiat. Res. 149, 59-67 (1998).
3. K. Sax, An analysis of X-ray induced chromosomal aberrations in Tradescantia. Genetics 25, 41-68 (1940).
4. D. E. Lea, Actions of Radiations on Living Cells. Cambridge University Press, London, 1946.
5. S. H. Revell, The breakage-and-reunion theory and the exchange theory for chromosomal aberrations induced by ionizing radiations: A short history. In Advances in Radiation Biology, Vol. 4 (J. T. Lett, H. Adler and M. Zelle, Eds.), pp. 367-416. Academic Press, New York, 1974.
6. S. B. Curtis, Lethal and potentially lethal lesions induced by radiation - A unified repair model. Radiat. Res. 106, 252-270 (1986); Erratum, Radiat. Res. 119, 584 (1989).
7. C. A. Tobias, E. A. Blakely, F. Q. H. Ngo and T. C. Yang, The repair-misrepair model of cell survival. In Radiation Biology in Cancer Research (R. E. Meyn and H. R. Withers, Eds.), pp. 195-229. Raven Press, New York, 1980.
8. G. Iliakis, The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays 13, 641-648 (1991).
9. P. E. Bryant, Rejoining and expression of radiation-induced DNA double strand breaks in mammalian cells. In Radiation Research 1895-1995, Vol. 2 (U. Hagen, D. Harder, H. Jung and C. Streffer, Eds.), pp. 368-371. Universitätsdruckerei H. Sturtz AG, Würzburg, 1995.
10. J. H. Peacock, M. R. de Almodovar, T. J. McMillan and G. G. Steel, The nature of the initial slope of radiation cell survival curves. Br. J. Radiol. 24 (Suppl.), 57-60 (1992).
11. E. van Rongen, E. L. Travis and H. D. Thames, Repair rate in mouse lung after clinically relevant radiation doses per fraction. Radiat. Res. 141, 74-78 (1995).
12. J. F. Ward, The complexity of DNA damage: Relevance to biological consequences. Int. J. Radiat. Biol. 66, 427-432 (1994).
13. D. Frankenberg and V. Michalik, Two types of double strand breaks in electron and photon tracks and their relation to exchange-type chromosome aberrations. Radiat. Environ. Biophys. 35, 163-169 (1996).
14. R. Greinert, E. Detzler, B. Volkmer and D. Harder, Kinetics of the formation of chromosome aberrations in X-irradiated human lym- phocytes: Analysis by premature chromosome condensation with delayed fusion. Radiat. Res. 144, 190-197 (1995).
15. A. Chatterjee and W. R. Holley, Energy deposition mechanisms and biochemical aspects of DNA strand breaks by ionizing radiation. Int. J. Quant. Chem. 391, 709-727 (1991).
16. P. J. Hahnfeldt, R. K. Sachs and L. R. Hlatky, Evolution of DNA damage in irradiated cells. J. Math. Biol. 30, 493-511 (1992).
17. A. M. Chen, J. N. Lucas, D. J. Brenner, F. S. Hill and R. K. Sachs, Proximity effects for chromosome aberrations measured by FISH. Int. J. Radiat. Biol. 69, 411-420 (1996).
18. S. Y. Ahn, B. Nevaldine and P. J. Hahn, Direct measurement by pulsed-field gel electrophoresis of induction and rejoining of X-ray-induced double-strand breaks in cultured mouse cells. Int. J. Radiat. Biol. 59, 661-675 (1991).
19. S. J. Whitaker and T. J. McMillan, Pulsed-field gel electrophoresis in the measurement of DNA double-strand break repair in xrs-6 and CHO cell lines: DNA degradation under some conditions interferes with the assessment of double-strand break rejoining. Radiat. Res. 130, 389-392 (1992).
20. B. Nevaldine, J. A. Longo, G. A. King, M. Vilenchik, R. H. Sagerman and P. J. Hahn, Induction and repair of DNA double-strand breaks. Radiat. Res. 133, 370-374 (1993).
21. C. A. Tobias, The repair-misrepair model in radiobiology: Comparison to other models. Radiat. Res. 104, S77-S95 (1985).
22. D. C. Lloyd and A. A. Edwards, Chromosome aberrations in human lymphocytes: Effect of radiation quality, dose, and dose rate. In Radiation-Induced Chromosome Damage in Man (T. Ishihara and M. S. Sasaki, Eds.), pp. 23-49. Alan R. Liss, New York, 1983.
23. M. N. Cornforth and J. Bedford, Ionizing radiation damage and its early development in chromosomes. In Advances in Radiation Biology, Vol. 17 (J. T. Lett and W. K. Sinclair, Eds.), pp. 423-496. Academic Press, San Diego, 1993.
24. R. K. Sachs, P. Hahnfeldt and D. J. Brenner, The link between dose-response relations and the underlying kinetics of DSB induction/repair/misrepair. Int. J. Radiat. Biol., in press.