Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases

Journal of Neurochemistry

Volumn 70, Issue 1, 1998, Pages 374-383

  Laslop, Andrea ^a   Weiss, Christian ^a   Savaria, Diane ^b   Eiter, Christine ^a   Tooze, Sharon A ^c   Seidah, Nabil G ^b   Winkler, Hans ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Chromogranins; PACE4; PC1; PC2; PE 11; Secretoneurin

Indexed keywords

CHROMOGRANIN B; FURIN; SECRETOGRANIN II; SECRETONEURIN;

ANIMAL CELL; ARTICLE; GEL FILTRATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT;

ANIMALIA; VACCINIA; VACCINIA VIRUS;

EID: 0031961983     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70010374.x     Document Type: Article

References (37)

1. Aardal S., Helle K. B., Elsayed S., Reed R. K., and Serck-Hanssen G. (1993) Vasostatins, comprising the N-terminal domain of chromogranin A, suppress tension in isolated human blood vessel segments. J. Neuroendocrinol. 5, 405-412.
2. Arden S. D., Rutherford N. G., Guest P. C., Curry W. J., Bailyes E. M., Johnston C. F., and Hutton J. C. (1994) The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. Biochem. J. 298, 521-528.
3. Benjannet S., Leduc R., Adrouche N., Falgueyret J. P., Marcinkiewicz M., Seidah N. G., Mbikay M., Lazure C., and Chrétien M. (1987) Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues. FEBS Lett. 224, 142-148.
4. Benjannet S., Rondeau N., Day R., Chrétien M., and Seidah N. G. (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl. Acad. Sci. USA 88, 3564-3568.
5. Braks J. A. M. and Martens G. J. M. (1995) The neuroendocrine chaperone 7B2 can enhance in vitro POMC cleavage by prohormone convertase PC2. FEBS Lett. 371, 154-158.
6. Burnette W. N. (1981) "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112, 195-203.
7. DeBie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., and Seidah N. G. (1996) The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. J. Cell Biol. 135, 1261-1275.
8. Dittié A. S. and Tooze S. A. (1995) Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells. Biochem. J. 310, 777-787.
9. Dong W., Marcinkiewicz M., Vieau D., Chrétien M., Seidah N. G., and Day R. (1995) Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J. Neurosci. 15, 1778-1796.
10. Eskeland N. L., Zhou A., Dinh T. Q., Wu H., Parmer R. J., Mains R. E., and O'Connor D. T. (1996) Chromogranin A processing and secretion. Specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. J. Clin. Invest. 98, 148-156.
11. Fischer-Colbrie R. and Frischenschlager I. (1985) Immunological characterization of secretory proteins of chromaffin granules: chromogranins A, chromogranins B, and enkephalin-containing peptides. J. Neurochem. 44, 1854-1861.
12. Fischer-Colbrie R., Laslop A., and Kirchmair R. (1995) Secretogranin II: molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin. Prog. Neurobiol. 46, 49-70.
13. Flanagan T., Taylor L., Poulter L., Viveros O. H., and Diliberto E. J. Jr. (1990) A novel 1745-dalton pyroglutamyl peptide derived from chromogranin B is in the bovine adrenomedullary chromaffin vesicle. Cell. Mol. Neurobiol. 10, 507-523.
14. Hoflehner J., Eder U., Laslop A., Seidah N. G., Fischer-Colbrie R., and Winkler H. (1995) Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin. FEBS Lett. 360, 294-298.
15. Johnson R. C., Darlington D. N., Hand T. A., Bloomquist B. T., and Mains R. E. (1994) PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status. Endocrinology 135, 1178-1185.
16. Kiefer M. C., Tucker J. E., Joh R., Landsberg K. E., Saltman D., and Barr P. J. (1991) Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol. 10, 757-769.
17. Kirchmair R., Gee P., Hogue-Angeletti R., Laslop A., Fischer-Colbrie R., and Winkler H. (1992) Immunological characterization of the endoproteases PC1 and PC2 in adrenal chromaffin granules and in the pituitary gland. FEBS Lett. 297, 302-305.
18. Kirchmair R., Hogue-Angeletti R., Gutierrez J., Fischer-Colbrie R., and Winkler H. (1993) Secretoneurin - a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C). Neuroscience 53, 359-365.
19. Kirchmair R., Leitner B., Fischer-Colbrie R., Marksteiner J., Hogue-Angeletti R., and Winkler H. (1995) Large variations in the proteolytic formation of a chromogranin A-derived peptide (GE-25) in neuroendocrine tissues. Biochem. J. 310, 331-336.
20. Kroesen S., Marksteiner J., Leitner B., Hogue-Angeletti R., Fischer-Colbrie R., and Winkler H. (1996) Rat brain: distribution of immunoreactivity of PE-11, a peptide derived from chromogranin B. Eur. J. Neurosci. 8, 2679-2689.
21. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
22. Lazure C., Benjannet S., Seidah N. G., and Chrétien M. (1991) Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts. Int. J. Peptide Protein Res. 38, 392-400.
23. Linard C. G., Mbikay M., Seidah N. G., and Chrétien M. (1990) Primary structure of mouse chromogranin B deduced from cDNA sequence. Nucleic Acids Res. 18, 1298.
24. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
25. Marcinkiewicz M., Day R., Seidah N. G., and Chrétien M. (1993) Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and α-melanotropin. Proc. Natl. Acad. Sci. USA 90, 4922-4926.
26. Martens G. J. M., Braks J. A. M., Eib D. W., Zhou Y., and Lindberg I. (1994) The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2. Proc. Natl. Acad. Sci. USA 91, 5784-5787.
27. Nielsen E., Welinder B. S., and Madsen O. D. (1991) Chromogranin-B, a putative precursor of eight novel rat glucagonoma peptides through processing at mono-, di-, or tribasic residues. Endocrinology 129, 3147-3156.
28. Rehemtulla A., Barr P. J., Rhodes C. J., and Kaufman R. J. (1993) PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 32, 11586-11590.
29. Schmid K. W., Weiler R., Xu R. W., Hogue-Angeletti R., Fischer-Colbrie R., and Winkler H. (1989) An immunological study on chromogranin A and B in endocrine and nervous tissues. Histochem. J. 21, 365-373.
30. Seidah N. G., Marcinkiewicz M., Benjannet S., Gaspar L., Beaubien G., Mattei M. G., Lazure C., Mbikay M., and Chrétien M. (1991) Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol. Endocrinol. 5, 111-122.
31. Seidah N. G., Chrétien M., and Day R. (1994) The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Biochimie 76, 197-209.
32. Seidah N. G., Hamelin J., Mamarbachi M., Dong W., Tadros H., Mbikay M., Chrétien M., and Day R. (1996a) cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. USA 93, 3388-3393.
33. Seidah N. G., Benjannet S., Pareek S., Savaria D., Hamelin J., Goulet B., Laliberté J., Lazure C., Chrétien M., and Murphy R. A. (1996b) Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem. J. 314, 951-960.
34. Strub J.-M., Garcia-Sablone P., Lonning K., Taupenot L., Hubert P., Van Dorsselaer A., Aunis D., and Metz-Boutigue M.-H. (1995) Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity. Eur. J. Biochem. 229, 356-368.
35. Tatemoto K., Efendic S., Mutt V., Makk G., Feistner G. J., and Barchas J. D. (1986) Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324, 476-478.
36. Winkler H. and Fischer-Colbrie R. (1992) The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49, 497-528.
37. Zhu X. and Lindberg I. (1995) 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. J. Cell Biol. 129, 1641-1650.