B-lymphocyte suppression in multiple myeloma is a reversible phenomenon specific to normal B-cell progenitors and plasma cell precursors

British Journal of Haematology

Volumn 100, Issue 1, 1998, Pages 176-183

  Rawstron, Andrew C ^a   Davies, Faith E ^a   Owkn, Roger G ^a   English, Anne ^a   Pratt, Guy ^a   Child, J Anthony ^a   Jack, Andrew S ^a   Morgan, Gareth J ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

B cell progenitors; Immunoparesis; Multiple myeloma; Plasma cell precursors

Indexed keywords

CD19 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; CD5 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; IMMUNOGLOBULIN;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; FLOW CYTOMETRY; GROWTH REGULATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOPHENOTYPING; IMMUNOREGULATION; LYMPHOCYTE SUBPOPULATION; MULTIPLE MYELOMA; PLASMA CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; RECURRENCE RISK; RELAPSE;

ADULT; AGED; ANTIGENS, CD; B-LYMPHOCYTES; BONE MARROW CELLS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; HUMANS; IMMUNOPHENOTYPING; LYMPHOPENIA; MALE; MIDDLE AGED; MULTIPLE MYELOMA; PLASMA CELLS; RECURRENCE; STEM CELLS;

EID: 0031961959     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00525.x     Document Type: Article

References (30)

1. Bakkus, M.H., Van Riet, I., Van Camp, B. & Thielemans, K. (1994) Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. British Journal of Haematology, 87, 68-74.
2. + circulating B cells in multiple myeloma have a rearranged IgH VDJ identical to that of autologous plasma cells as quantitated by in-situ RT-PCR. Blood, 88, (Suppl. 1), 391.
3. + peripheral blood cells expressing CD 38, CB56, and monotypic Ig light chain. Blood, 85, 456-447.
4. Billadcau, D., Ahmann, G., Greipp, P. & Van Ness, B. (1993) The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. Journal of Experimental Medicine, 178, 1023-1031.
5. Billadeau, D., Quam, L., Thomas, W., Kay, N., Greipp, P., Kyle, R., Oken, M.M. & Van Ness, B. (1992) Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients. Blood, 80, 1818-1824.
6. Billadeau, D., Van Ness, B., Kimlinger, T., Kyle, R.A., Therneau, T.M., Greipp, P.R. & Witzig, T.E. (1996) Clonal circulating cells are common in plasma cell proliferative disorders: a comparison of monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and active myeloma, Blood, 88, 289-296.
7. Chen, B.J. & Epstein, J. (1996) Circulating clonal lymphocytes in myeloma constitute a minor subpopulalion of B cells. Blood, 87, 1972-1976.
8. Chiu, E.K., Ganeshaguru, K., Hoffbrand, A.V. & Mehta, A.B. (1989) Circulating monoclonal B lymphocytes in multiple myeloma. British Journal of Haematology, 72, 28-31.
9. Civin, C.I., Trischmann, T.M., Fackler, M.J., Bernstein, I.D., Buhring, H., Campos, L., Greaves, M.F., Kamoun, M., Katz, D.R., Landsorp, P.M., Look, A.T., Seed, B., Sutherland, D.R., Tindle, R.W. & Uehanska-Ziegler, B. (1989) Report on the CD34 cluster workshop. In: Knapp, W., Dörken, B., Gilks, W.R., Rieber, E.P., Schmidt, R.E., Stein, H., von dem Boine, A.E.G.Kr. (eds) Leucocyte Typing IV, pp. 818-825. Oxford University Press.
10. Corradini, P., Boccadoro, M., Voena, C. & Pileri, A. (1993) Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to C mu sequence in immunoglobulin (IgG)- and IgA-secreting multiple myelomas. Journal of Experimental Medicine, 178, 1091-1096.
11. Duperray, C., Bataille, R., Boiron, J.M., Haagen, I.A., Cantaloube, J.F., Zhang, X.G., Boucheix, C. & Klein, B. (1991) No expansion of the pre-B and B-cell compartments in the bone marrow of patients with multiple myeloma. Cancer Research, 51, 3224-3228.
12. Farnen, J.P., Tyrkus, M., Hanson, C.A., Cody, R.L. & Emerson, S.G. (1991) Characterization of a new human multiple myeloma cell line, UMJF-2, which suppresses antibody production by B-lymphocytes in vitro. Leukemia, 5, 574-84.
13. Harada, H., Kawano, M.M., Huang, N., Harada, Y., Iwato, K., Tanabe, O., Tanaka, H., Sakai, A., Asaoku, H. & Kuramoto, A. (1993) Phenotypic difference of normal plasma cells from mature myeloma cells. Blood, 81, 2658-2663.
14. Harada, Y., Kawano, M.M., Huang, N., Mahmoud, M.S., Lisukov, I.A., Mighara, K., Tsujimoto, T. & Kuramoto, A. (1996) Identification of carly plasma cells in peripheral blood and their clinical significance. British Journal of Haematology, 92, 184-191.
15. Jensen, G.S., Belch, A.R., Kherani, F., Mant, M.J., Ruether, B.A. & Pilarski, L.M. (1992) Restricted expression of immunoglobulin light chain mRNA and of the adhesion molecule CD1 1b on circulating monoclonal B lineage cells in peripheral blood of myeloma patients. Scandinavian Journal of Immunology, 36, 843-853.
16. Jensen, G.S., Belch, A.R., Mant, M.J., Ruether, B.A., Yacyshyn, B.R. & Pilarski, L.M. (1993) Expression of multiple beta 1 integrins on circulating monoclonal B cells in patients with multiple myeloma. American Journal of Hematology, 43, 29-36.
17. + monoclonal B-lineage cells in peripheral blood from myeloma patients as late stage B cells. Blood, 78, 711-719.
18. Kawano, M., Iwato, K., Asaoku, H., Tanabe, O., Tanaka, H., Ishikawa, H. & Kuramoto, A. (1989) Altered cytokine activities are related to the suppression of synthesis of normal immunoglobulin in multiple myeloma. American Journal of Hematology, 30, 91-96.
19. King, M.A. & Radicchi, M.A. (1992) Monitoring circulating B cells in patients with multiple myeloma at diagnosis or in plateau phase: how prevalent is light chain isotype suppression? British Journal of Haematology, 81, 218-222.
20. Kubagawa, H., Vogler, L.B., Capra, J.D., Conrad, M.E., Lawton, A.R. & Cooper, M.D. (1979) Studies on the clonal origin of multiple myeloma: use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of origin cell. Journal of Experimental Medicine, 150, 792-807.
21. Owen, R.G., Johnson, R.J., Rawstron, A.C., Evans, P.A., Jack, A.S., Smith, G.M., Child, J.A. & Morgan, G.J. (1996) Assessment of IgH-PCR strategies in multiple myeloma. Journal of Clinical Pathology, 49, 672-675.
22. Quesada, S., Leo, R., Deicher, H. & Peest, D. (1995) Functional and biochemical characteristics of a soluble B lymphocyte proliferation-inhibiting activity produced by bone marrow cells from multiple myeloma patients. Cellular Immunology, 162, 275-81.
23. Rawstron, A.C., Owen, R.G., Davies, F.E., Johnson, R.J., Jones, R.A., Richards, S.J., Evans, P.A., Child, J.A., Smith, G.M., Jack, A.S. & Morgan, G.J. (1997) Circulating plasma cells in multiple myeloma: characterization and correlation with disease stage. British Journal of Haematology, 97, 46-55.
24. Sanderson, R.D., Lalor, P. & Bernfield, M. (1989) B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regulation, 1, 27-35.
25. + cells. In: Wunder, E., Sovalat, H., Hénon, P.R. & Serke, S. (eds) Hematopoietic Stem Cells: the Mulhouse Manual, pp. 67-78. AlphaMed Press. Ohio.
26. Takishita, M., Kosaka, M., Goto, T. & Saito, S. (1994) Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies. British Journal of Haematology, 87, 735-742.
27. Tienhaara, A. & Pelliniemi, T.T. (1994) Peripheral blood B lymphocytes in multiple myeloma. Acta Haematologica, 91, 57-61.
28. Tsujimoto, T., Lisukov, I.A., Huang, N., Mahmoud, M.S. & Kawano, M.M. (1996) Plasma cells induce apoptosis of pre-B cells by interacting with bone marrow stromal cells. Blood, 87, 3375-3383.
29. Turley, E.A., Belch, A.J., Poppema, S. & Pilarski, L.M. (1993) Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes. Blood, 81, 446-453.
30. Zola, H. (1995) CD10 workshop panel report. In: Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J.M., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R., Springer, T., Tedder, T.F. & Todd, R.F. (eds) Leucocyte Typing V, Volume 1, pp. 505-507. Oxford University Press.