Rare alteration of genomic structure or expression of the DPC4 gene in myelogenous leukemias

Acta Haematologica

Volumn 99, Issue 4, 1998, Pages 187-190

  Kaneko, Hiroto ^a   Horiike, Shigeo ^a   Sasai, Yuri ^a   Iwai, Toshiki ^a   Nakao, Makoto ^a   Yokota, Shouhei ^a   Taniwaki, Masafumi ^a   Kashima, Kei ^a   Misawa, Shinichi ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Deletion; DPC4; Expression; Mutation; Myelogenous leukemia

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL CRISIS; CANCER GENETICS; CANCER RECURRENCE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE STRUCTURE; HOMOZYGOSITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MYELOID LEUKEMIA; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RNA-DIRECTED DNA POLYMERASE; SMAD4 PROTEIN; TRANS-ACTIVATORS;

EID: 0031961401     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000040837     Document Type: Article

References (23)

1. Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271:350-353.
2. Hahn SA, Hoque ATMS, Moskaluk CA, da Costa LT, Schutte M, Rozenblum E, Seymour AB, Weinstein CL, Yeo CJ, Hruban RH, Kern SE: Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res 1996;56:490-494.
3. bcr/abl gene of the Philadelphia chromosome. Science 1990;247:824-830.
4. Nakai H, Misawa S, Toguchida J, Yandell DW, Ishizaki K: Frequent p53 gene mutation in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res 1992;52:6588-6592.
5. Nakai H, Misawa S, Horiike S, Taniwaki M, Seriu T, Shimazaki C, Fujii H, Maekawa T, Furukawa T, Abe T, Ishizaki K, Kashima K: Analysis of mutations and expression of GAP-related domain of the neurofibromatosis 1 (NF1) gene in the progression of chronic myelogenous leukemia. Leukemia 1994;8:1027-1033.
6. Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 1994; 13:504-510.
7. Wada C, Shionoya S, Fujino Y, Tokuhiro H, Akahoshi T, Uchida T, Ohtani H: Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia. Blood 1994;83:3449-3456.
8. Silly H, Chase A, Mills KI, Apfelbeck U, Sormann S, Goldman JM, Cross NCP: No evidence for microsatellite instability or consistent loss of heterozygosity at selected loci in chronic myeloid leukemia blast crisis. Leukemia 1994;8:1923-1928.
9. Mori N, Takeuchi S, Tasaka T, Lee S, Spira S, Ben-Yehuda D, Mizoguchi H, Schiller G, Koeffler HP: Absence of microsatellite instability during the progression of chronic myelocyticleukemia. Leukemia 1997;11:151-152.
10. Radich RP, Kopecky KJ, Willman CL, Weick J, Head D, Appelbaum F, Collins SJ: N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance. Blood 1990;76:801-807.
11. Slingerland JM, Minden MD, Benchimol S: Mutation of the p53 gene in human acute myelogenous leukemia. Blood 1991;77:1500-1507.
12. Swansbury GJ, Lawler SD, Alimena G, Arthur D, Berger R, Van den Berghe H, Bloomfield CD, de la Chappelle A, Dewald G, Garson OM, Hagemeijer A, Mitelman F, Rowley JD, Sakurai M: Long-term survival in acute myelogenous leukemia: A second follow-up of the fourth international workshop on chromosomes in leukemia. Cancer Genet Cytogenet 1994;73:1-7.
13. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 1985; 103:620-625.
14. Campbell IG, Beynon G, Davis M, Englefield P: LOH and mutation analysis of CDKN2 in primary human ovarian cancers. Int J Cancer 1995;63:222-225.
15. Hayashi K: PCR-SSCP; A simple and sensitive method for detection of mutation of the genomic DNA. PCR Methods Appl 1991;1:34-38.
16. Merlo A, Herman JG, Mao L, Lee DJ; Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;1:686-692.
17. Fenaux P, Jonveaux P, Quiquandon I, Lai JL, Pignon JM, Loucheux-Lefebvre MH, Bauters F, Berger R, Kerckaert JP: p53 gene mutations in acute myeloid leukemia with 17p monosomy. Blood 1991;78:1652-1657.
18. Kim SK, Fan Y, Papadimitrakopoulou V, Clayman G, Hittelman WN, Hong WK, Lotan R, Mao L: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res 1996;56:2519-2521.
19. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casaro RA, Meltzer PS, Hahn SA, Kern SE: DPC4 gene in various tumor types. Cancer Res 1996; 56:2527-2530.
20. Barrett MT, Schutte M, Kern SE, Reid BJ: Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma. Cancer Res 1996;56:4351-4353.
21. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B: Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 1996;13: 343-346.
22. Caldas C, Hahn S, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994;8:27-32.
23. Beltinger CP, White PS, Sulman EP, Maris JM, Brodeur GM: No CDKN2 mutations in neuroblastoma. Cancer Res 1995;55:2053-2055.