Toxicity, mutagenicity, and behavioral effects of β-CIT, a ligand for dopamine transporter exploration by SPECT

Nuclear Medicine and Biology

Volumn 25, Issue 4, 1998, Pages 405-409

  Emond, P ^a   Farde, L ^b   Chalon, S ^a   Belzung, C ^c   Mauclaire, V ^d   Chiron, J P ^c   Halldin, C ^b   Besnard, J C ^a   Guilloteau, D ^a  

^a INSERM   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITÉ DE TOURS   (France)

^d CIS Bio International   (France)

Author keywords

CIT; Dopamine; SPECT; Toxicity

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE DERIVATIVE; DOPAMINE; DOPAMINE TRANSPORTER; RADIOLIGAND;

ALZHEIMER DISEASE; AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEGENERATION; CONTROLLED STUDY; DRUG ABUSE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; LETHAL DOSE; LOCOMOTION; MALE; MOUSE; MUTAGENICITY; NONHUMAN; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL TRANSPORT; COCAINE; DOPAMINE; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MICE; MOTOR ACTIVITY; MUTAGENESIS; MUTAGENICITY TESTS; RATS; RATS, SPRAGUE-DAWLEY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0031961267     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00227-8     Document Type: Article

References (27)

1. Ames B. N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella mammalian mutagenicity test. Mutation Res. 31:1975;347-364.
2. Asenbaum S., Brücke T., Pirker W., Podreka I., Angelberger P., Wenger S., et al. Imaging of dopamine transporters with iodine-123-β-CIT and SPECT in Parkinson's disease. J. Nucl. Med. 38:1997;1-6.
3. Boja J. W., Kuhar M. J., Kopajtic T., Yang E., Abraham P., Lewin A. H., et al. Secondary amine analogues of 3β-(4′-substituted phenyl)tropane-2β-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters. J. Med. Chem. 37:1994;1220-1223.
4. 125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse. 12:1992;27-36.
5. 125I]RTI-55 A potent ligand for dopamine transporters . Eur. J. Pharmacol. 194:1991;133-134.
6. Boja J. W., Carroll F. I., Rahman M. A., Philip A., Lewin A. H., Kuhar M. J. New, potent cocaine analogs Ligand binding and transport studies in rat striatum . Eur. J. Pharmacol. 184:1990;329-332.
7. Carroll F. I., Kotian P., Dehghani A., Gray J. L., Kuzemko M. A., Parham K. A., et al. Cocaine and 3β-(4′-substituted phenyl)tropane-2β-carboxylic acid ester and amide analogues New high-affinity and selective compounds for the dopamine transporter . J. Med. Chem. 38:1995;379-388.
8. Clarke R. L., Daum S. J., Gambino A. J., Aceto M. D., Pearl J., Levitt M., et al. Compounds affecting the central nervous system 4. 3β-phenyltropane-2-carboxylic esters and analogs . J. Med. Chem. 16:1973;1260-1267.
9. Cline E. J., Scheffel U., Boja J. W., Carroll F. I., Katz J. L., Kuhar M. J. Behavioral effects of novel cocaine analogs A comparison with in vivo receptor binding potency . J. Pharmacol. Exp. Ther. 260:1992;1174-1179.
10. 11C]β-CIT binding to monoamine transporters in the monkey and human brain. Synapse. 16:1994;93-103.
11. Farde L., Halldin C., Nagren K., Suhara T., Karlsson P., Schoeps K-O., et al. Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart. Eur. J. Nucl. Med. 21:1994;345-347.
12. 11C]raclopride. Psychopharmacology. 107:1992;23-29.
13. Farde L., Hall H., Ehrin E., Sedvall G. Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science. 231:1986;258-261.
14. Ginovart N., Lundin A., Farde L., Halldin C., Swahn C., Pauli S., et al. PET-study of pre- and postsynaptic dopaminergic markers for the neurodegenerative process in Huntington's disease. Brain. 120:1997;503-514.
15. Hemby S. E., Co C., Reboussin D., Davies H. M. L., Dworkin S. I., Smith J. E. Comparison of a novel tropane analog of cocaine, 2β-Propanoyl-3β-(4-tolyl) tropane with cocaine HCl in rats Nucleus accumbens extracellular dopamine concentration and motor activity . J. Pharmacol. Exp. Ther. 273:1995;656-666.
16. Innis R. B., Seibyl J. P., Scanley B. E., Laruelle M., Abi-Dargham A., Wallace E., et al. Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 90:1993;11965-11969.
17. 123I]CIT. Eur. J. Pharmacol. 200:1991;369-370.
18. Kuikka J. T., Bergström K. A., Vanninen E., Laulumaa V., Hartikainen P., Länsimies E. Initial experience with single-photon emission tomography using iodine-123-labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane in human brain. Eur. J. Nucl. Med. 20:1993;783-786.
19. Kung M-P., Essman W. D., Frederick D., Meegalla S., Goodman M., Mu M., et al. IPT A novel iodinated ligand for the CNS dopamine transporter . Synapse. 20:1995;316-324.
20. 50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exp. Biol. Med. 57:1944;261-264.
21. 11C]β-CIT, a cocaine analogue Preparation, autoradiography and preliminary PET investigations . Nucl. Med. Biol. 20:1993;249-255.
22. Porrino L. J., Davies H. M. L., Childers S. R. Behavioral and local cerebral metabolic effects of the novel tropane analog, 2β-propanoyl-3β-(4-tolyl)-tropane. J. Pharmacol. Exp. Ther. 272:1995;901-910.
23. Porrino L. J., Migliarese K., Davies H. M. L., Saikali E., Childers S. R. Behavioral effects of the novel tropane analog, 2β-Propanoyl-3β-(4-toluyl)-tropane (PTT). Life Sci. 54:1994;511-517.
24. Rose C. L., Coles H. W., Thompson H. E. Studies in the pharmacology of local anesthetics III. Comparison of gamma-(2-methyl piperidino)-propyl benzoate hydrochloride with cocaine and procaine on experimental animals . J. Lab. Clin. Med. 15:1930;731-735.
25. 11C]β-CIT uptake in the primate peripheral organs measured by PET. Ann. Nucl. Med. 10:1996;85-88.
26. 125I-labelled β-CIT and its ω-fluoroalkyl analogues β-CIT-FE and β-CIT-FP, including synthesis of precursors. J. Label. Compd. Radiopharm. 38:1996;675-685.
27. Zea-Ponce Y., Baldwin R. M., Laruelle M., Wang S., Neumeyer J. L., Innis R. B. Simplified multidose preparation of iodine-123-β-CIT A marker for dopamine transporters . J. Nucl. Med. 36:1995;525-529.