Meiotic stability of transgene expression is unaffected by flanking matrix-associated regions

Molecular Breeding

Volumn 4, Issue 1, 1998, Pages 47-58

  Conner, Anthony J ^a,b   Mlynárová, Ludmila ^a,c   Stiekema, Willem J ^a   Nap, Jan Peter ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b New Zealand Institute of Plant and Food Research   (New Zealand)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Environmental stress; Gene silencing; Genome stability; Kanamycin resistance; Nicotiana tabacum; Seedling screen

Indexed keywords

BACKCROSSING; BETA GLUCURONIDASE; GENE TARGETING; GENETIC STABILITY; MATRIX ASSOCIATED REGION; MEIOSIS; TOBACCO; TRANSGENIC PLANT;

DNA; GENE EXPRESSION; GENETIC ENGINEERING; PLANTS (BOTANY); TOBACCO;

ENVIRONMENTAL STRESS; GENE SILENCING; GENETIC INSTABILITY; GENOME STABILITY; KANAMYCIN RESISTANCE; KANAMYCINS; MATRIX; NICOTIANA TABACUM; SEEDLING SCREEN; TRANSGENE EXPRESSION;

STABILITY;

EID: 0031960697     PISSN: 13803743     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009637513628     Document Type: Article

References (47)

1. Assaad FF, Signer ER: Somatic and germinal recombination of a direct repeat in Arabidopsis. Genetics 132: 553-566 (1992).
2. Bender J, Fink GR: Epigenetic control of an endogenous gene family is revealed by a novel blue fluorescent mutant of Arabidopsis. Cell 83: 725-734 (1995).
3. Brusslan JA, Karlin-Neumann GA, Huang L, Tobin EM: An Arabidopsis mutant with a reduced level of cab140 RNA is a result of cosuppression. Plant Cell 5: 667-677 (1993).
4. Cherdshewasart W, Gharti-Chhetri GB, Saul MW, Jacobs M, Negrutiu I: Expression instability and genetic disorders in transgenic Nicotiana plumbaginifolia Viv. plants. Trans Res 2: 307-320 (1993).
5. Chyi Y-S, Jorgensen RA, Goldstein D, Tanksley SD, Loaiza-Figueroa F: Locations and stability of Agrobacterium-mediated T-DNA insertions in the Lycopersicon genome. Mol Gen Genet 204: 64-69 (1986).
6. Conner AJ, Christey MC: Plant breeding and seed marketing options for the introduction of transgenic insect-resistant crops. Biocontrol Sci Tech 4: 463-473 (1994).
7. Czernilofsky AP, Hain R, Baker B, Wirtz V: Studies on the structure and functional organisation of foreign DNA integrated into the genome of Nicotiana tabacum. DNA 5: 473-482 (1986).
8. Darwin C: The Variation of Animals and Plants under Domestication, vol II. John Murray, London (1868).
9. Dehio C, Schell J: Stable expression of a single-copy rolA gene in transgenic Arabidopsis thaliana plants allows an exhaustive mutagenic analysis of the transgene-associated phenotype. Mol Gen Genet 241: 359-366 (1993).
10. de Vries H: The Mutation Theory: Experiments and Observations on the Origin of Species in the Vegetable Kingdom. Open Court, Chicago (1901).
11. Dorer DR, Henikoff S: Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77: 993-1002 (1994).
12. Gal S, Pisan B, Hohn T, Grimsley N, Hohn B: Genomic homologous recombination in planta. EMBO J 10: 1571-1578 (1991).
13. Gharti-Chhetri GB, Cherdshewasart W, Dewulf J, Jacobs M, Negratiu I: Polyethylene glycol-mediated direct gene transfer in Nicotiana spp. Physiol Plant 85: 345-351 (1992).
14. Hänisch ten Cate CH, Loonen AEHM, Ottaviani MP, Ennik L, van Eldik G, Stiekema WJ: Frequent spontaneous deletions of Ri T-DNA in Agrobacterium rhizogenes transformed potato roots and regenerated plants. Plant Mol Biol 14: 735-741 (1990).
15. Heberle-Bors E, Charvat B, Thompson D, Schernthaner JP, Barta A, Matzke AJM, Matzke MA: Genetic analysis of T-DNA insertions into the tobacco genome. Plant Cell Rep 7: 571-574 (1988).
16. KNMI: Maandoverzicht van het weer in Nederland. MOW Bull 91 (No. 6-9): 1-10 (1994).
17. Jorgensen R: Cosuppression, flower color patterns, and metastable gene expression states. Science 268: 686-691 (1995).
18. Laemmli UK, Käs E, Poljak L, Adachi Y: Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr Opin Genet Devel 2: 275-285 (1992).
19. Lebel EG, Masson J, Bogucki A, Paszkowski J: Stress-induced intrachromosomal recombination in plant somatic cells. Proc Natl Acad Sci USA 90: 422-426 (1993).
20. Linn F, Heidmann I, Saedler H, Meyer P: Epigenetic changes in the expression of the maize A1 gene in Petunia hybrida: role of numbers of integrated gene copies and state of methylation. Mol Gen Genet 222: 329-336 (1990).
21. Matzke MA, Matzke AJM: How and why do plants inactivate homologous (trans)genes? Plant Physiol 107: 679-685 (1995).
22. McClintock B: The significance of responses of the genome to challenge. Science 226: 792-801 (1984).
23. Meyer P, Linn F, Heidmann I, Meyer zu Altenschildesche H, Niedenoff I, Saedler H: Endogenous and environmental factors influence 35S promoter methylation of a maize A1 gene con-struct in transgenic petunia and its colour phenotype. Mol Gen Genet 231: 345-352 (1992).
24. Mlynárová L, Loonen A, Heldens J, Jansen RC, Keizer P, Stiekema WJ, Nap JP: Reduced position effect in mature transgenic plants conferred by the chicken lysozyme matrix-associated region. Plant Cell 6: 417-426 (1994).
25. Mlynárová L, Jansen RC, Conner AJ, Stiekema WJ, Nap JP: The MAR-mediated reduction in position effect can be uncoupled from copy number-dependent expression in transgenic plants. Plant Cell 7: 599-609 (1995).
26. Mlynárová L, Keizer LCP, Stiekema WJ, Nap JP: Approaching the lower limit of transgene variability. Plant Cell 8: 1589-1599 (1996).
27. Müller AJ, Mendel RR, Schiemann J, Simoens C, Inzé D: High meiotic stability of a foreign gene introduced into tobacco by Agrobacterium-mediated transformation. Mol Gen Genet 207: 171-175 (1987).
28. Murashige T, Skoog F: A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-497 (1962).
29. Nap JP, Conner AJ, Mlynárová L, Stiekema WJ, Jansen RC: Dissection of a synthesized quantitative trait to characterize transgene interactions. Genetics 147: 315-320 (1997).
30. Payne RW, Lane PW, Digby PGN, Harding SA, Leech PK, Morgan GW, Todd AD, Thompson R, Tunnicliffe Wilson G, Welham SJ, White RP: Genstat 5 (Release 3) Reference Manual. Clarendon Press, Oxford (1993).
31. Peterhans A, Schlüpmann H, Basse C, Paszkowski J: Intrachromosomal recombination in plants. EMBO J 9: 3437-3445 (1990).
32. Potrykus I, Paszkowski J, Saul MW, Petruska J, Shillito RD: Molecular and general genetics of a hybrid foreign gene introduced into tobacco by direct gene transfer. Mol Gen Genet 199: 169-177 (1985).
33. Puchta H, Swoboda P, Gal S, Blot M, Hohn B: Somatic intrachromosomal homologous recombination events in populations of plant siblings. Plant Mol Biol 28: 281-292 (1995).
34. Renckens S, De Greve H, Van Montagu M, Hernalsteens J-P: Petunia plants escape from negative selection against a transgene by silencing the foreign DNA via methylation. Mol Gen Genet 233: 53-64 (1992).
35. Rohlf FJ, Sokal RR: Statistical Tables, 3rd ed. Freeman and Co, New York (1994).
36. Sabl JF, Henikoff S: Copy number and orientation determine the susceptibility of a gene to silencing by nearby heterochromatin in Drosophila. Genetics 142: 447-458 (1996).
37. Simmonds NW: Principles of Crop Improvement. Longman, London (1979).
38. Smith CJS, Watson CF, Bird CR, Ray J, Schuch W, Grierson D: Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants. Mol Gen Genet 224: 477-481 (1990).
39. Sokal RR, Rohlf FJ: Biometry, 3rd ed. Freeman and Co, New York (1995).
40. Swoboda P, Hohn B, Gal S: Somatic homologous recombination in planta: The recombination frequency is dependent on the allelic state of recombining sequences and may be influenced by genomic position effects. Mol Gen Genet 237: 33-40 (1993).
41. Swoboda P, Gal S, Hohn B, Puchta H: Intrachromosomal homologous recombination in whole plants. EMBO J 13: 484-489 (1994).
42. Tovar J, Lichtenstein C: Somatic and meiotic chromosomal recombination between inverted duplications in transgenic tobacco plants. Plant Cell 4: 319-322 (1992).
43. UPOV: The Revised General Introduction to the Guidelines for the Conduct of Tests for Distinctiveness, Homogeneity and Stability of New Varieties of Plants. UPOV, Geneva (1979).
44. Vaucheret H: Identification of a general silencer for 19S and 35S promoters in a transgenic tobacco plant: 90 bp of homology in the promoter sequence are sufficient for transinactivation. CR Acad Sci Paris 316: 1471-1483 (1993).
45. Walbot V, Cullis CA: Rapid genomic change in higher plants. Annu Rev Plant Physiol 36: 367-396 (1985).
46. Walter C, Broer I, Hillemann D, Pühler A: High frequency, heat treatment-induced inactivation of the phosphinothricin resistance gene in transgenic single cell suspension cultures of Medicago sativa. Mol Gen Genet 235: 189-197 (1992).
47. Wernsman EA, Matzinger DF: Tobacco. In: Fehr WR, Hadley H (eds) Hybridization of Crop Plants, pp. 657-668. American Society of Agronomy, Madison, WI (1980).