Ranitidine and nizatidine stimulate antral smooth muscle contractility via excitatory cholinergic mechanisms

Digestive Diseases and Sciences

Volumn 43, Issue 3, 1998, Pages 497-505

  Parkman, Henry P ^a,b   Pagano, Anthony P ^a   Ryan, James P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

Acid secretion; Antrum; Gastrointestinal motility; Gastrointestinal smooth muscle; Histamine type 2 receptor antagonists

Indexed keywords

ACETYLCHOLINE; CIMETIDINE; FAMOTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; NIZATIDINE; OMEGA CONOTOXIN; RANITIDINE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC ACTIVITY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; FORCE TRANSDUCER; GUINEA PIG; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; STOMACH ANTRUM; STOMACH MUSCLE;

ANIMALS; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; GUINEA PIGS; HISTAMINE H2 ANTAGONISTS; MUSCLE, SMOOTH; NIZATIDINE; PYLORIC ANTRUM; RANITIDINE; RECEPTORS, CHOLINERGIC;

EID: 0031958741     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018846604627     Document Type: Article

References (48)

1. Huscher C, Falchetti D, Besozzi F, Dessanti A, Ekema G, Felini C, Bossini S, Beretta T: Ranitidinc and total gastric emptying of liquids and solids. Curr Ther Res 36:916-420, 1984
2. Houghton LA, Read RW: A comparative study of the effect of cimetidine and ranitidine on the rate of gastric emptying of liquid and solid test meals in man. Aliment Pharmacol Ther 1:401-408, 1987
3. Ueki S, Seiki M, Yoneta T, Aita H, Chaki K, Hori Y, Morita H, Tagashira E, Itoh Z: Gastrokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats. J Pharmacol Exp Ther 264:152-157, 1993
4. Scarpignato C, Bertaccini G, Zimharo G, Vitulo F: Ranitidine delays gastric emptying of solids in man. Br J Clin Pharmacol 13:252-253, 1982
5. Corinaldesi R, Scarpignato C, Galassi A, Stanghellini V, Calamelli R, Bertaccini G, Barbara L: Effect of ranitidine and cimetidine on gastric emptying of a mixed meal in man. Int J Clin Pharmacol 22:498-501, 1984
6. Logan RFA, Forrest JAH, McLoughlin GP, Lidgard G, Heading RC: Effect of cimetidine on serum gastrin and gastric emptying in man. Digestion 18:220-226, 1978
7. Scopinaro F, Gatti V, Bilotti D, Liberatore M, Vignoni A, Corazziari E: A therapeutic oral dose of cimetidine and ranitidine does not affect gastric emptying. Ital J Gastroenterol 16:226-228, 1984
8. Parikh R, Sweetland J, Forster ER, Bedding AW, Farr SJ, Smith JTL: Ranitidine bismuth citrate and ranitidine do not affect gastric emptying of a radio-labeled liquid meal. Br J Clin Pharmacol 38:577-580, 1994
9. 2-receptor involvement in the regulation of gastric emptying. Am J Physiol 250:G244-G247, 1986
10. 2-receptor blockade on gastric emptying and serum gastrin in man. Scott Med J 21:23-27, 1976
11. 2-receptor antagonist ranitidine. Agents Actions 12:168-171, 1982
12. Poli E, Coruzzi G, Bertaccini G: Ranitidine hut not famotidine releases acetylcholine from the guinea pig myenteric plexus. Agents Actions 30:141-194, 1990
13. Lee HS, Cheah LS, Gwee CE: Inhibition of acethylcholinesterase by histamine agonists and antagonists. Clin Exp Pharmacol Physiol 12:613-620, 1985
14. Mizumoto A, Fujimura M, Iwanaga Y, Miyashita N, Yoshida N, Kondo Y, Itoh Z: Anticholinesterase activity of histamine H2-receptor antagonists in the dog: Their possible role in gastric motor activity. J Gastrointest Motil 2:273-280, 1990
15. Parkman HP, Wang MB, Ryan JP: Decreased electromechanical activity of guinea pig circular muscle during pregnancy. Gastroenterology 105:1306-1312, 1993
16. Bauer AJ, Sanders KM: Gradient in excitation-contraction coupling in canine antral circular muscle. J Physiol (London) 369:283-294, 1985
17. Bitar KN, Makhlouf GM: Receptors on smooth muscle cells: characterization by contraction and specific antagonists. Am J Physiol 242:G400-G407, 1982
18. Hillemeier AC, Bitar KN, Biancani P: Development characteristics of the kitten antrum. Gastroenterology 101:339-343, 1991
19. Deoras KS, Wolfson MR, Searls RL, Hilfer SR, Sheffeild JB, Shaffer TH: Use of a touch sensitive screen and computer assisted image analysis for quantitation of developmental changes in pulmonary structure. Pediatr Pulmonol 9:109-118, 1990
20. McCleskey EW, Fox AP, Feldman DH, Cruz LJ, Olivera BM. Tsien RW, Yoshikami D: Omega-conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc Natl Acad Sci USA 84:4327-4331, 1987
21. Zappia L, Sianesi M, Bertaccini G: Action of H2-receptor antagonists on the motility of human gastrointestinal tract in vitro. Ital J Gastroenterol 16:281-283, 1984
22. Kurosawa S, Nishikawa S, Kancko M, Ro S, Yakabi K, Nakamura T: The contractile effects of 112 receptor antagonists nizatidine, ranitidine, famotidine and cimetidine on guinea pig gastric muscle. Gastroenterology 108:A634, 1995 (abstract)
23. 2 receptor antagonists partly through inhibition of acetylcholinesterase. Gastroenterol Jpn 21:213-219, 1986
24. Hansen WE, Bertl S: The inhibition of acetylcholinesterase and pseudocholinesterase by cimetidine. Drug Res 33:161-163, 1983
25. Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou V: The inhibition of acetylcholinesterase by ranitidine: A study on the guinea pig ileum. J Pharmacobiodyn 9:941-945, 1986
26. Gwee MCE, Cheah LS: Actions of cimetidine and ranitidine at some cholinergic sites: Implications in toxicology and anesthesia. Life Sci 39:383-388, 1986
27. Galli A, Mantovani P, Pepeu G: Effect of ranitidine on ileal myenteric plexus preparation and on acetyl- and butyrylcholinesterase. Biochem Pharmacol 33:1845-1850, 1984
28. 2 receptors coupled to distinct signal transduction pathways in isolated intestinal muscle cells. J Pharmacol Exp Ther 264:598-603, 1993
29. Nakazawa S, Ichikawa T, Naito Y, Tsukamoto Y: Effect of histamine on the gastric smooth muscles of guinea pig. Digestion 22:203-209, 1981
30. 2) histamine receptors in gallbladder muscle. Gastroenterology 72:932-936, 1977
31. 2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon. J Pharmacobiodyn 15:561-565, 1992
32. 2-receptors on guinea pig ileum myenteric plexus neurons mediate the release of contractile agents. J Pharmacol Exp There 221:69-79, 1982
33. Re L, Cingolani ML, Concettoni C, Rossini L: Cholinergic effects of cimetidine and ranitidine. Pharmacol Res Commun 15:485-517, 1983
34. Sasho S, Obase H, Ichikawa S, Kitazawa T, Nonaka H, Yoshizaki R, Ishii A, Shuto K: Synthesis of 2-imidazolidinylidene propanadinitrile derivatives as stimulators of gastrointestinal motility-III. Bioorg Med Chem 3:279-287, 1995
35. Reynolds JC, Putnam PE: Prokinetic agents. Gastroenterol Clinics North Am 21:567-596, 1992
36. Physicians' Desk Reference, 49th edition. Montvale, New Jersey, Medical Economics Data Production Company, 1995
37. 2 receptor stimulation increases gastric emptying in monkeys. Am J Physiol 255:G767-G771, 1988
38. 2-receptor antagonists on gastrointestinal motility and gastric emptying. J Smooth Muscle Res 29:131-142, 1993
39. Fioramonti J, Soldani G, Honde C, Bueno L: Effects of ranitidine and oxmetidine on gastrointestinal motility in conscious dog. Agents Actions 15:260-263, 1984
40. McCallum RW, Fink SM, Lerner E, Berkowitz DM: Effects of metoclopramide and bethanechol on delayed gastric emptying present in gastroesophageal reflux patients. Gastroenterology 84:1573-1577, 1983
41. Hamilton SG, Sheiner HJ, Quinlan MF: Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man. Gut 17:273-279, 1976
42. Hunt JH, Knox MT: The slowing of gastric emptying by four strong acids and four weak acids. J Physiol 222:187-208, 1972
43. Cooke AR: Duodenal acidification: Role of first part of duodenum in gastric emptying and secretion in dogs. Gastroenterology 67:85-92, 1974
44. Forrest JAH, Fettes M, McLoughlin GP, Heading RC: Effect of long-term cimetidine on gastric acid secretion, serum gastrin, and gastric emptying. Gut 20:404-407, 1979
45. Kerrigan DD, Mangnall YF, Read NW, Johnson AG: Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine. Gut 32:1295-1297, 1991
46. Benini L, Castellani G, Bardelli E, Semhenini C, Brentegani MT, Caliari S, Vantini I: Omeprazole causes delay in gastric emptying of digestible meals. Dig Dis Sci 41:469-474, 1996
47. Rasmussen L, Oster-Jorgensen E, Qvist N, Kraglund K, Hovendal C, Pedersen SA: Short report: A double-blind placebo-controlled trial of omeprazole on characteristics of gastric emptying in healthy subjects. Aliment Pharmacol Ther 5:85-89, 1991
48. Parkman HP, Miller MA, Trate DM, Urbain J-L, Knight LC, Brown KL, Maurer AH, Fisher RS: Effect of gastric acid suppressants on human gastric motility. Gastroenterology 110:A731, 1996 (abstract)