Partial liquid ventilation improves gas exchange and increases EELV in acute lung injury

Journal of Applied Physiology

Volumn 84, Issue 5, 1998, Pages 1566-1572

  Gauger, Paul G ^a   Overbeck, Michael C ^a   Chambers, Sean D ^a   Cailipan, Christine I ^a   Hirschl, Ronald B ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Department of Anesthesiology   (United States)

Author keywords

Body plethysmography; End expiratory lung volume; Oleic acid; Partial liquid ventilation; Perfluorocarbon

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BODY PLETHYSMOGRAPHY; EXPIRATORY RESERVE VOLUME; LAMB; LUNG ALVEOLUS; LUNG GAS EXCHANGE; LUNG INJURY; LUNG VENTILATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0031958613     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.84.5.1566     Document Type: Article

References (21)

1. Clark, L. C., Jr., and F. Gollan. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 152: 1755-1756, 1966.
2. Colebatch, H. J. H., and L. A. Engel. Measurement of lung volume in paralyzed cats. J. Appl. Physiol. 36: 614-617, 1974.
3. Colton, D. M., R. B. Hirschl, K. J. Johnson, G. O. Till, S. B. Dean, and R. H. Bartlett. Neutrophil infiltration is reduced during partial PFC liquid ventilation in the setting of lung injury. Surg. Forum 45: 668-670, 1994.
4. Curtis, S. E., J. T. Peek, and D. R. Kelly. Partial liquid breathing with perflubron improves arterial oxygenation in acute canine lung injury. J. Appl. Physiol. 75: 2696-2702, 1993.
5. Derks, C. M., and D. Jacobovitz-Derks. Embolic pneumopathy induced by oleic acid. Am. J. Pathol. 87: 143-158, 1977.
6. Fuhrman, B. P., P. R. Paczan, and M. DeFrancis. Perfluorocarbon-associated gas exchange. Crit. Care Med. 19: 712-722, 1991.
7. Gattinoni, L., L. D'Andrea, P. Pelosi, G. Vitale, A. Pesenti, and R. Furnagalli. Regional effects and mechanism of positive end-expiratory pressure in early adult respiratory distress syndrome. JAMA 269: 2122-2127, 1993.
8. Gauger, P. G., M. C. Overbeck, S. D. Chambers, E. D. Weber, and R. B. Hirschl. Measuring functional residual capacity in normal and oleic acid injured lungs. J. Surg. Res. 63: 204-208, 1996.
9. Hernan, L. J., B. P. Fuhrman, R. Kaiser, S. Penfil, C. Foley, M. C. Papo, and C. L. Leach. Perfluorocarbon associated gas exchange in normal and acid-injured-large sheep. Crit. Care Med. 24: 475-481, 1996.
10. Hirschl, R. B., M. C. Overbeck, A. Parent, R. Hernandez, S. Schwartz, A. Dosanjh, K. Johnson, and R. Bartlett. Liquid ventilation provides uniform distribution of perfluorocarbon in the setting of respiratory failure. Surgery 116: 159-168, 1994.
11. Hirschl, R. B., A. Parent, R. Tooley, M. McCracken, K. Johnson, T. Shaffer, M. Wolfson, and R. H. Bartlett. Liquid ventilation improves pulmonary function, gas exchange and lung injury in a model of respiratory failure. Ann. Surg. 221: 79-88, 1995.
12. King, E. G., H. S. Weily, E. Genton, and D. G. Ashbaugh. Consumption coagulopathy in the canine oleic acid model of fat embolism. Surgery 69: 533-541, 1971.
13. Lachmann, B., B. Robertson, and J. Vogel. In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol. Scand. 24: 231-236, 1980.
14. Laver, M. B., J. Morgan, H. H. Bendixen, and E. P. Radford, Jr. Lung volume, compliance, and arterial oxygen tensions during controlled ventilation. J. Appl. Physiol. 19: 725-733, 1964.
15. Lowe, C., and T. H. Shaffer. Pulmonary vascular resistance in the fluorocarbon-fllled lung. J. Appl. Physiol. 60: 154-159, 1986.
16. Modell, J. H., E. J. Newby, and B. C. Ruiz. Long-term survival of dogs after breathing oxygenated fluorocarbon liquid. Federation Proc. 29: 1731-1736, 1970.
17. Overbeck, M. C., T. Pranikoff, C. Yadao, and R. B. Hirschl. Efficacy of partial perfluorocarbon liquid ventilation in a large animal model of acute respiratory failure. Crit. Care Med. 24: 1208-1214, 1996.
18. Shaffer, T. H., M. R. Wolfson, and L. C. Clark, Jr. State of the art review: liquid ventilation. Pediatr. Pulmonol. 14: 102-109, 1992.
19. Smith, T., D. Steinhorn, K. Marcucci, K. Thusu, P. Dandona, and B. Fuhrman. A liquid perfluorochemical decreases the in vitro production of reactive oxygen species by alveolar macrophages. Crit. Care Med. 23: 1533-1539, 1995.
20. Tooley, R., R. B. Hirschl, A. Parent, and R. H. Bartlett. Total liquid ventilation with perfluorocarbon increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis. Crit. Care Med. 24: 268-273, 1996.
21. Tutuncu, A. S., N. S. Faithfull, and B. Lachmann. Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome. Crit. Care Med. 21: 962-969, 1993.