Effect of several cellulosic binders and method of their addition on the properties and binder distribution of granules prepared in an agitating fluidized bed

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 3, 1998, Pages 488-493

  Kokubo, Hiroyasu ^a   Nakashima, Chinatsu ^b   Sunada, Hisakazu ^b  

^a SHIN ETSU CHEMICAL CO LTD   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

Agitating fluidized bed granulation; Binder distribution; Cellulose ether; Dye distribution; Granulation mechanism; Granule size distribution

Indexed keywords

DYE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; METHYLCELLULOSE; STARCH; WATER;

ARTICLE; DRUG GRANULATION; MODEL; PARTICLE SIZE; SOLUBILITY; VISCOSITY;

EID: 0031958081     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.488     Document Type: Article

References (11)

1. Kokubo H., Nakamura S., Sunada H., Chem. Pharm. Bull, 41, 2151-2155 (1993).
2. Kokubo H., Nakamura S., Sunada H., Chem. Pharm. Bull., 43, 1402-1406 (1995).
3. Kokubo H., Sunada H., Chem. Pharm. Bull., 44, 1546-1549 (1996).
4. Kokubo H., Sunada H., Chem. Pharm. Bull., 45, 1069-1072 (1997).
5. Myo N., Takei N., J. Soc. Powder Technol., Japan, 26, 103-107 (1989).
6. Kapur P. C., Chem. Engng. Sci., 27, 1863-1869 (1972).
7. Schaefer T., Woerts O., Arch. Pharm. Chem. Sci., 6, 69-82 (1978).
8. Nishimura K., Kakizawa H., Fukazawa T., Kishitani S., Kasahara K., Asai T., Yakuzaigakit, 38, 196-204 (1978).
9. Wan L. S. C., Lim K. S., S. T. P. Pharm., 5, 244-250 (1989).
10. Park H. J., Testin R. F., Vergano P. J., Weller C. L., J. Food Sci., 58, 1361-1370 (1993).
11. Kristensen H. G., Schæfer T., Drug Dev. Ind. Pharm., 13, 803-872 (1987).