Seizure recurrence and risk factors after withdrawal of chronic antiepileptic therapy in children

Seizure

Volumn 7, Issue 2, 1998, Pages 107-114

  Caviedes, Benigno E ^a,b   Herranz, Jose L ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

Anticonvulsants; Children; Epilepsy; Risk factors; Withdrawal

Indexed keywords

ANTICONVULSIVE AGENT;

ADOLESCENT; ARTICLE; CHILD; DISEASE DURATION; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; FEMALE; FOCAL EPILEPSY; FRONTAL CORTEX; GENERALIZED EPILEPSY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; RETROSPECTIVE STUDY; RISK FACTOR; SEIZURE; SPIKE WAVE;

EID: 0031957469     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1059-1311(98)80065-4     Document Type: Article

References (45)

1. De Negri, M., Doria, R., Gaggero, R. and Rolando, S: L'evolution des épilepsies infantiles et leur pronostic a l'adolescence. Neuropsychiatrie de l'enfance 1983; 31 (11-12): 507-514.
2. Reynolds, E.H. Early treatment and prognosis of epilepsy. Epilepsia 1987; 28: 97-106.
3. Sillanpää, M. Children with epilepsy as adults: outcome after 30 years of follow-up. Acta Paediat. Scand. 1990; 79 (Suppl. 368): S1-S78.
4. Beghi, E. et al for the collaborative Group for the study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia 1992; 33: 45-51.
5. Swingler, R.J., Davidson, D.L.W., Roberts, R.C. and Moulding, F.: The cost of epilepsy in 'patients attending a specialist epilepsy service. Seizure 1994; 3: 115-120.
6. Begley, C.H.E., Annegers, J.F., Lairson, D.R., Reynolds, T.F. and Hauser, W.A. Cost of epilepsy in the United States: A model based on incidence and prognosis. Epilepsia 1994; 35: 1230-1243, 1994.
7. Emerson, R., D'Souza, B.J., Vining, E.P., Holden, K.R., Mellits, E.D. and Freeman, J.M. Stopping 'medication in children with epilepsy. N. Engl. J. Med. 1981; 304: 1125-1129.
8. Hollowach, J., Thurston, D.L., O'Leary, J. Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy. N. Engl. J. Med. 1982; 306: 831-836.
9. Todt, H. The late prognosis of epilepsy in childhood: results of a prospective follow-up 'study. Epilepsia 1984; 25: 137-144, 1984.
10. Shinnar, S., Vining, E., Mellits, E.D., D'Souza, B.J., Holden, K., Baumgardner, R.A. and Freeman, J.M. Discontinuing antiepileptic medication in children with epilepsy after two years without seizures. N. Engl. J. Med. 1985; 313: 976-980.
11. Bouma, P.A.D., Peters, A.C.B., Arts, R.J.H.M., Stijnen, T. and Van Rosum, J. Discontinuation of antiepileptic therapy: a prospective study in children. J. Neurol. Neurosurg. Psychiatry 1987; 50: 1579-1583.
12. Tsai, J.J. and Schmidt, D. Seizure relapse in epilepsy with complex partial seizures. In Advances in Epileplology: XVIth Epilepsy International Symposium. (Eds P. Wolf, M. Dam, D. Janz and F. Dreifuss) New York; Raven Press, 1987: pp. 405-408.
13. Arts, W.F.M., Visser, L.H., Loonen, M.C.B., Tjiam, A.T., Stroink, H., Stuurman, P.M. and Poortvliet, D.C.J.: Follow-up of 146 children with epilepsy after withdrawal of antiepileptic therapy. Epilepsia 1988; 29: 244-250.
14. Callaghan, N., Garret, A. and Goggin, T.: Withdrawal of anticonvulsant drugs in patients free of seizures for two years. N. Engl. J. Med. 1988; 318: 942-946.
15. Ehrhardt, P. and Forsythe, W.I.: Prognosis after grand-mal seizures: a study of 187 children with three-year remissions. Develop. Med. Child. Neurol. 1989; 31: 633-639.
16. Medical Research Council Antiepileptic Drugs Withdrawal Study Group, randomised study of antiepileptic drugs withdrawal in patients in remission. Lancet 1991; 337: 1175-1180.
17. Medical Research Council Antiepileptic Drugs Withdrawal Study Group: prognostic index for recurrence of seizures after remission of epilepsy. B.M.J. 1993; 306: 1374-1378.
18. Gherpelli, J.L., Kok, F., Dal Forno, R., Elkis, L.C., Lefevre, B. and Diament, A.J. Discontinuing medication in epileptic children: A study of risk factors related to recurrence. Epilepsia 1992; 33: 681-686.
19. Mastropaolo, C., Tondi, M., Carboni, F., Manca, S. and Zoroddu, F. Prognosis after therapy discontinuation in children with epilepsy. Eur. Neurol. 1992; 32: 141-145.
20. Shinnar, S., Berg, A.T., Moshé, S.L., Kang, H., O'Dell, C., Alemany, M., Godelsohn, E.S. and Hauser, W.A. Discontinuing antiepileptic drugs in children with epilepsy: a prospective study. Ann. Neurol. 1994; 35: 534-545.
21. Overweg, J., Binnie, C.D., Oosting, J. and Rowan, A.J. Clinical and EEG prediction of seizure recurrence following antiepileptic drug withdrawal. Epilepsy Res. 1987; 1: 272-283.
22. Ohtsuka, Y., Yamatogi, Y., Oka, E. and Ohtahara, S. Treatment and discontinuation of antiepileptic drugs in childhood epilepsy. Folia Psychiat. Neurol. Jpn. 1982; 36: 279-286.
23. Matricardi, M., Brinciotti, M. and Benedetti, P. Outcome after discontinuation of antiepileptic drug therapy in children with epilepsy. Epilepsia 1989; 30: 598-589.
24. Donati, F., Hassink, R.I., Jung, H., and Vasella, F. Factors predicting the risk of relapse after antiepileptic drug discontinuation in children with partial seizures. Eur. J. Pediatr. 1995; 154 (Suppl. 3): S44-S47.
25. Annegers, J.F., Hauser, W.A. and Elveback, L.R. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979; 20: 729-737.
26. Uesugi, H., Kojima, K., Miyasaka, M., Matsuura, M., Ohtaka, T., Moriiwa, M. and Shimazono, Y. Discontinuation of antiepileptic drug treatment in controlled seizure patients. J. Epilepsy 1994; 7: 178-188.
27. Oller-Daurella, L. and Oller, L. Revisión de 157 epilépticos que llevan más de 5 años sin tratamiento y sin crisis. Rev. Esp. Epilepsia 1987; 2: 5-10.
28. Pestre, M., Loiseau, P., Larrieu, E., Dartigues, J.F. and Cohadon, S. Withdrawal of antiepileptic drug therapy in adolescent epileptic patients. In Advances in Epileptology: XVIth epilepsy International Symposium. (Eds P. Wolf, M. Dam, D. Janz and F. Dreifuss) New York; Raven Press, 1987: pp. 395-400.
29. Procaccianti, G., Lugaresi, E., Tinuper, P., Serracchioli, A., Ripamonti, L. and Baruzzi, A. Antiepileptic drug withdrawal: Preliminary results of a prospective study. In Advances in Epileptology: XVIth Epilepsy International Symposium. (Eds P. Wolf, M. Dam, D. Janz and F. Dreifuss) New York; Raven Press, 1987: pp. 379-382.
30. Duncan, J.S., Shorvon, S.D. and Trimble, M.R. Discontinuation of phenytoin, carbamazepine and valproate in patients with active epilepsy. Epilepsia 1990; 31: 324-333.
31. Duncan, J.S., Patsalos, P.N. and Shorvon, S.D. Effects of discontinuation of phenytoin, carbamazepine and valproate on concomitant antiepileptic medication. Epilepsia 1991; 32: 101-115.
32. Brodie, M.J. Drug interactions in epilepsy. Epilepsia 1992; 33 (Suppl. 1): S13-S22.
33. Scarpa, P., Faggioli, L., De Carlo, B. and Cavaliere, B. Interruzione della terapia nel bambino epilettico: Follow-up di 206 casi. Riv. Ital. Pediatr. 1995; 21: 434-438.
34. Tennison, M., Greenwood, R., Lewis, D. and Thorn, M. Discontinuing antiepileptic drugs in children with epilepsy. N. Engl. J. Med. 1994; 330: 1407-1410.
35. Medical Research Council Antiepileptic Drugs Withdrawal Study Group: Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors taht influence it. Epilepsia 1996; 37: 1043-1050.
36. Shafer, S.Q., Hauser, W.A., Annegers, J.F. and Klass, D.W. EEG and other early predictors of epilepsy remission: A community study. Epilepsia 1988; 29: 590-600.
37. Oller-Daurella, L. and Oller, L. Supresión del tratamiento antiepiléptico en 840 casos. Rev. Neurol. 1992; 106: 245-249.
38. Berg, A.T. and Shinnar, S. Relapse following discontinuation of antiepileptic drugs: A meta-analysis. Neurology 1994; 44: 601-608.
39. Overweg, J. Withdrawal of antiepileptic drugs (AEDs) in seizure- free patients, risk factors for relapse with special attention for the EEG. Seizure 1995; 4: 19-36.
40. Tinuper, P., Avoni, P., Provini, F., Riva, R., Lugaresi, E. and Baruzzi, A.: Antiepileptic drug discontinuation in partial epilepsies: a prospective study of EEG prognostic factors. Epilepsia 1993; 34 (Suppl. 6): S65.
41. Tinuper, P., Avoni, P., Riva, R., Provini, F., Lugaresi, E., and Barazzi, A. The prognostic value of the electroencephalogram in antiepileptic drug withdrawal in partial epilepsies. Neurology 1996; 47: 76-78
42. Galimberti, C.A., Manni, R., Parietti, L., Marchioni, E. and Tartara, A. Drug withdrawal in patients with epilepsy: prognostic value of the EEG. Seizure 1993; 2: 213-220.
43. Todt, H. Risk of relapse after discontinuation drug therapy: Results of a new prospective follow-up study. Epilepsia 1993; 34 (Suppl. 2): S7.
44. Andersson, T., Braathen, G., Persson, A. and Theorell, K. A comparison between one and three years of treatment in uncomplicated childhood epilepsy: A prospective study. The EEG as predictor of outcome after withdrawal of treatment. Epilepsia 1997; 38: 225-232.
45. Okuma, T. and Kumashiro, H. Natural history and prognosis of epilepsy: report of a multi-institutional study in Japan. Epilepsia 1981; 22: 35-53.