Metal (molybdenum, copper) accumulation and retention in brain, pituitary and other organs of ammonium tetrathiomolybdate-treated sheep

British Journal of Nutrition

Volumn 79, Issue 4, 1998, Pages 329-331

  Haywood, Susan ^a   Dincer, Zuhal ^a   Holding, J ^b   Parry, Nicola M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Princess   (United Kingdom)

Author keywords

Copper; Molybdenum; Tetrathiomolybdate; Toxicity

Indexed keywords

COPPER; METAL; MOLYBDENUM; TETRATHIOMOLYBDATE AMMONIUM;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN; CEREBELLUM; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HEART; HYPOPHYSIS; KIDNEY; LIVER; MALE; MEDULLA OBLONGATA; MUSCLE; NONHUMAN; OVARY; SHEEP; SUBCUTANEOUS DRUG ADMINISTRATION; TESTIS; TIME;

ANIMALS; BRAIN; COPPER; FEMALE; KIDNEY; LIVER; MALE; METALS; MOLYBDENUM; MUSCLE, SKELETAL; PITUITARY GLAND; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 0031957365     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19980056     Document Type: Article

References (7)

1. Allain P & Krari N (1991) Diethyldithiocarbamate, copper and neurological disorders. Life Sciences 48, 291-299.
2. Brewer, GJ, Dick RD, Yuzbasiyan-Gurkan V, Tankanow R, Young AB & Kluin KJ (1991) Initial therapy of patients with Wilson's disease with tetrathiomolybdate. Archives of Neurology 48, 42-47.
3. Dincer Z (1994) Copper toxicity in sheep: Studies on copper chelation by ammonium tetrathiomolybdate (TTM) and metallothionein. PhD Thesis, University of Liverpool.
4. Haywood S, Dincer Z & Humphries WR (1993) Endocrinopathy and brain copper elevation in tetrathiomolybdate treated sheep. In Trace Elements in Man and Animals. Proceedings of the Eight International Symposium on Trace Elements in Man and Animals (TEMA-8), Dresden pp. 601-602 [M Anke, D Meissner and CF Mills, editors]. Gersdorf: Verlag Media Touristik.
5. Humphries WR, Morrice PC & Bremner I (1988) A convenient method for the treatment of chronic copper poisoning in sheep using subcutaneous ammonium tetrathiomolybdate. Veterinary Record 9, 51-53.
6. Mason J, Lamand M, Tressol JC & Mulryan G (1988) Studies on the changes in systemic copper metabolism and excretion produced by the intravenous administration of trithiomolybdate in sheep. British Journal of Nutrition 59, 289-300.
7. Phillippo M, Humphries WR, Atkinson T, Henderson GD & Garthwaite PH (1987) The effect of dietary molybdenum and iron on copper status, puberty, fertility and oestrous cycles in cattle. Journal of Agricultural Science 109, 321-336.