In vitro stimulation of renal tubular p-aminohippurate transport by dexamethasone in rat kidneys and in intact kidney tissue of patients suffering from renal cell carcinoma

Urological Research

Volumn 26, Issue 2, 1998, Pages 143-148

  Fleck, C ^a   Kratochwil, E ^a   Winterstein, K ^a   Gockeritz S ^a   Schubert, J ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Dexamethasone; P aminohippurate; Renal cell carcinoma; Renal tubular transport; Stimulation; Triiodothyronine

Indexed keywords

4 AMINOHIPPURIC ACID; DEXAMETHASONE; LIOTHYRONINE;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

AGED; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARCINOMA, RENAL CELL; DEXAMETHASONE; FEMALE; HUMANS; KIDNEY CORTEX; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; MIDDLE AGED; P-AMINOHIPPURIC ACID; RATS; RATS, WISTAR; TRIIODOTHYRONINE;

EID: 0031957244     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002400050037     Document Type: Article

References (39)

1. Amato R, Meyers C, Ellerhorst J, Finn L, Kilbourn R, Sella A, Logothetis C (1995) A phase I trial of intermittent high-dose alpha-interferon and dexamethasone in metastatic renal cell carcinoma. Ann Oncol 6: 911
2. Bellamy WT (1996) P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol 36: 161
3. Berkhin EB, Varshavsky BY (1975) Substrate induction of tubular secretion of organic compounds in the kidney. Proc Acad Sci USSR 220: 1463
4. Bosch I, Croop J (1996) P-glycoprotein multidrug resistance and cancer. Biochim Biophys Acta 1288: F37
5. Bratton AC, Marshall EK (1939) A new coupling component for sulfonamide determination. J Biol Chem 128. 537
6. Bräunlich H (1981) Excretion of drugs during postnatal development. Pharmacol Ther 12: 299
7. Bräunlich H (1988) Hormonal control of postnatal development of renal tubular transport of weak organic acids. Pediatr Nephrol 2: 151
8. Bräunlich H, Fleck C. Bajanowski T, Miosge W (1983) Dosisabhängigkeit und Altersabhängigkeit des renalen tubulären Transportes von p-Aminohippursäure (PAH) bei Ratten nach Injektion von Einzeldosen. Pharmazie 38: 483
9. Bräunlich H, Jahn F, Bartha J (1987) Hemodynamic parameters and renal blood flow following stimulation of renal tubular transport processes by treatment with thyroid hormones. Pharmazie 42: 846
10. Bräunlich H, Köhler A, Schmidt I (1986) Acceleration of p-aminohippurate excretion in immature rats by dexamethasone treatment. Med Biol 64: 267
11. Chapman AE, Goldstein LJ (1995) Multiple drug resistance: biologic basis and clinical significance in renal-cell carcinoma. Semin Oncol 22: 17
12. Clayman RV, Figenshau RS, Prigge WF, Forstrom L, Gebhard RL (1987) Transport of circulating serum cholesterol by human renal cell carcinoma. J Urol 137: 1262
13. Efferth T, Fabry U, Osieka R (1995) Is there a realistic chance for the clinical modulation of multidrus resistance? Onkologie 18: 258
14. Fleck C (1997) In vitro stimulation of renal tubular p-aminohippurate transport by dexamethasone in kidney tissue of immature and adult rats. Exp Toxic Pathol 49: 487
15. Fleck C, Bräunlich H (1990) Age dependent differences in stimulation and compensation of renal and biliary transport processes. Arzneimittelforsch - Drug Res 40: 1047
16. Fleck C, Bräunlich H (1995) Renal handling of drugs and amino acids after impairment of kidney or liver function: influences of maturity and protective treatment. Pharmac Ther 67: 53
17. Fleck C, Bräunlich H, Stopp M (1981) Stimulation des renalen Fremdstofftransportes nach unilateraler Nephrektomie. Acta Biol Med Germ 40: 1053
18. Fleck C, Göckeritz S, Schubert J (1997) Tubular PAH transport capacity in human kidney tissue and in renal cell carcinoma: correlation with various clinical and morphological parameters of the tumor. Urol Res 25: 167
19. Fleck C, Aurich M, Schwertfeger M (1997) Stimulation of renal amino acid reabsorption after treatment with triiodothyronine or dexamethasone in amino acid loaded rats. Amino Acids 12: 265
20. Hissin PJ, Hilf R (1976) A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74: 214
21. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D (1996) Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res 56: 988
22. max. Z Versuchstierkd 32: 41
23. Leier I, Jedlitschky G, Buchholz U, Center M, Cole SP, Deeley RG, Keppler D (1996) ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J 314: 433
24. Licht T, Gottesman MM, Pastan I (1995) Transfer of the MDR 1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo. Cytokin Mol Ther 1:11
25. Mickisch GH (1994) Chemoresistance of renal cell carcinoma: 1986-1994. World J Urol 12: 214
26. Mickisch GH (1994) Multidrug Resistance des Nierenzellkarzinoms: von der Laborkuriosität zur klinischen Realität. Akta Urol 25: 327
27. Mickisch GH, Schroeder FH (1996) Multidrug resistance in renal cell carcinoma: eight years of experience. In: Luciani L, Debryne FMJ, Schalken AJ (eds) Basic research in urologic oncology. Karger, Basel, p 161
28. Mickisch GH, Merlino GT, Aiken PM, Gottesman MM, Pastan I (1991) New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene J Urol 146: 447
29. Motzer RJ, Lyn P, Fischer P, Lianes P, Ngo RL, Cordoncardo C, Obrien JP (1995) Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma. J Clin Oncol 13: 1958
30. Motzer RJ, Bander NH, Nanus DM (1996) Renal cell carcinoma. N Engl J Med 335: 865
31. Nishiyama K, Shirahama T, Yoshimura A, Sumizawa T, Furukawa T, Ichikawa-Haraguchi M, Akiyama S, Ohi Y (1993) Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas. Cancer 71: 3611
32. Rafestin-Oblin ME, Lombes M, Lustenberger P, Blanchardic P, Michaud A, Claire M (1986) Affinity of corticosteroids for mineralcorticoid and glucocorticoid receptors of the rabbit kidney: effect of steroid substitution. J Steroid Biochem 25: 527
33. Rohlff C, Glatzer RI (1995) Regulation of multidrug resistance through the cAMP and EGF signalling pathways. Cellular Signalling 7. 431
34. Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P (1995) Absence of the mdrla P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin. and cyclosporin A. J Clin Invest 96: 1698
35. Sharfman WH, Urba WJ, Smith JW, Janik JE, Curti BD, Gause BL, Holmlund JT. Steis RG, Beauchamp AE, Longo DL (1995) Phase I/II trial of 5-fluorouracil, leucovorin, zidovudine and dipyridamole for patients with metastatic colorectal cancer, renal cell carcinoma and malignant melanoma. Int J Oncol 6: 579
36. Stopp M, Bräunlich H (1975) Die Akkumulation von p-Aminohippursäure und Zyklopenthiazid in Nierenrindenschnitten verschieden alter Ratten und ihre Abhangigkeit von der Energiebereitstellung. Acta Biol Med Germ 34: 89
37. Traeger A, Bräunlich H, Bräunlich I, Geyer A, Hoppe H, Kubens S. Stein G (1976) Untersuchungen zur Kinetik von p-Aminohippursäure und von Sulfamerazin nach wiederholter Applikation von Sulfamerazin bei Schulkindern, Erwachsenen und Greisen. Dtsch Gesundh-Wesen 31: 2250
38. Villalobos AR, Dunnick CA, Pritchard JB (1996) Mechanisms mediating basolateral transport of 2,4-dichlorophenoxyacetic acid in rat kidney. J Pharmacol Exp Ther 278: 582
39. Volm M, Pommerenke EW, Efferth T, Lohrke H, Mattern J (1991) Circumvention of multi-drug resistance in human kidney and kidney carcinoma in vitro. Cancer 67: 2484