Magnesium deficiency: A cause of heterogenous disease in humans

Journal of Bone and Mineral Research

Volumn 13, Issue 4, 1998, Pages 749-758

  Rude, Robert K ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM;

BONE METABOLISM; DIETARY INTAKE; DISEASE ASSOCIATION; GASTROINTESTINAL DISEASE; HUMAN; KIDNEY DISEASE; MAGNESIUM DEFICIENCY; MAGNESIUM METABOLISM; MINERAL METABOLISM; REVIEW;

BONE DISEASES, METABOLIC; CARDIOVASCULAR DISEASES; ENZYMES; GASTROINTESTINAL DISEASES; HOMEOSTASIS; HUMANS; KIDNEY DISEASES; MAGNESIUM; MAGNESIUM DEFICIENCY; NEUROMUSCULAR DISEASES;

EID: 0031956454     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.4.749     Document Type: Review

References (169)

1. Aikawa JK 1976 Biochemistry and physiology of magnesium. In: Prasad AS, Oberleas D (eds.) Trace Elements in Human Health and Disease. Academic Press, New York, NY, U.S.A., pp. 47-78.
2. Rude RK, Oldham SB 1990 Disorders of magnesium metabolism. In: Cohen RD, Lewis B, Alberti KGMM, Denman AM (eds.) The Metabolic and Molecular Basis of Acquired Disease. London: Bailliere Tindall, pp. 1124-1148.
3. Elin R 1987 Assessment of magnesium status. Clin Chem 33:1965-1970.
4. Wallach S 1988 Availability of body magnesium during magnesium deficiency. Magnesium 7:262-270.
5. The biological chemistry of magnesium: Phosphate metabolism. In: Fraustro da Silva JJR, Williams RJP (eds.) The Biological Chemistry of the Elements. Oxford University Press, Oxford, U.K., pp. 243-267.
6. Romani A, Marfella C, Scarpa A 1993 Cell magnesium transport and homeostasis: Role of intracellular compartments. Miner Electrolyte Metab 19:282-289.
7. Romani A, Scarpa A 1992 Regulation of cell magnesium. Arch Biochem Biophys 298:1-12.
8. 2+ influx. Miner Electrolyte Metab 19:259-265.
9. Hwang DL, Yen CF, Nadler JL 1993 Insulin increases intracellular magnesium transport in human platelets. J Clin Endocrinol Metab 76:549-553.
10. Hua H, Gonzales J, Rude RK 1995 Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Magnes Res 8:359-366.
11. Wacker WEC, Parisi AF 1968 Magnesium metabolism. N Engl J Med 45:658, 663, 712-717, 772-776.
12. Garfinkel L, Garfinkel D 1985 Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium 4:60-72.
13. Connolly TM, Bross TE, Majerus PW 1985 Isolation of a phosphomonesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem 260:7868-7874.
14. Maguire ME 1984 Hormine-sensitive magnesium transport and magnesium regulation of adenylate cyclase. Trends Pharmacol Sci 5:73-77.
15. + pump. Am J Physiol 264:C457-C463.
16. Iseri LT, French JH 1984 Magnesium: Nature's physiologic calcium blocker. Am Heart J 108:188-193.
17. White RE, Hartzell HC 1989 Magnesium ions in cardiac function. Biochem Pharmacol 38:859-867.
18. Whang R, Flink EB, Dyckner T, Wester PO, Aikawa JK, Ryan MP 1985 Magnesium depletion as a cause of refractory potassium repletion. Arch Intern Med 145:1686-1689.
19. Kayne LH, Lee DBN 1993 Intestinal magnesium absorption. Miner Electrolyte Metab 19:210-217.
20. Fine KD, Santa Ana CA, Porter JL, Fordtran JS 1991 Intestinal absorption of magnesium from food and supplements. J Clin Invest 88:396-402.
21. 26Mg. Am J Clin Nutr 39:571-576.
22. Franz KB 1989 Influence of phosphorus on intestinal absorption of calcium and magnesium. In: Itokawa Y, Durlach J (eds.) Magnesium in Health and Disease. John Libbey & Co., London, U.K., pp. 71-78.
23. Wisker E, Nagel R, Tanudjaja TK, Feldheim W 1991 Calcium, magnesium, zinc, and iron balances in young women. Effects of low-phytate barley-fiber concentrate. Am J Clin Nutr 54:553-559.
24. Siener R, Hesse A 1995 Influence of a mixed and a vegetarian diet on urinary magnesium excretion and concentration. Br J Nutr 73:783-790.
25. Hunt MS, Schofield FA 1969 Magnesium balance and protein intake level in adult human female. Am J Clin Nutr 22:367-373.
26. Quamme GA, Dirks JH 1986 The physiology of renal magnesium handling. Renal Physiol 9:257-269.
27. Rude RK, Ryzen E 1986 TmMg and renal Mg threshold in normal man in certain pathophysiologic conditions. Magnesium 5:273-281.
28. Kesteloot H, Joossens JV 1990 The relationship between dietary intake and urinary excretion of sodium, potassium, calcium and magnesium: Belgian Interuniversity Research on Nutrition and Health. J Hum Hypertens 4:527-533.
29. Mahalko JR, Sandstead HH, Johnson LK, Milne DB 1983 Effect of a moderate increase in dietary protein on the retention and excretion of Ca, Cu, Fe, Mg, P, and Zn by adult males. Am J Clin Nutr 37:8-14.
30. Martinez ME, Salinas M, Miguel JL, Herrero E, Gomez P, Garcia J, Sanchez-Siiilia L, Montero A 1985 Magnesium excretion in idiopathic hypercalciuria. Nephron 40:446-450.
31. Massey LK, Whiting SJ 1993 Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 123:1611-1614.
32. Abbott L, Nadler J, Rude RK 1994 Magnesium deficiency in alcoholism: Possible contribution to osteoporosis and cardiovascular disease in alcoholics. Alcohol Clin Exp Res 18:1976-1082.
33. Institute of Medicine 1997 Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington, DC, U.S.A., pp. 6-1 to 6-45.
34. Cleveland LE, Goldman JD, Borrud LG 1996 Data tables: Results from USDA's 1994 continuing survey of food intakes by individuals and 1994 diet and health knowledge survey. Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD, U.S.A.
35. Mountokalakis T, Singhellakis P, Alevizaki C, Virvadakis K, Ikkos D 1980 Relationship between degree of renal failure and impairment of intestinal magnesium absorption. In: Magnesium in Health and Disease Seelig MS (ed.) Spectrum Publications, Inc., New York, NY, U.S.A., pp. 453-458.
36. Lowik MRH, van Dokkum W, Kistemaker C, Schaafasma G, Ockhuizen T 1993 Body composition, health status and urinary magnesium excretion among elderly people (Dutch nutrition surveillance system). Magnes Res 6(3):223-232.
37. Martin BJ 1990 The magnesium load test: Experience in elderly subjects. Aging 2:291-296.
38. Thoren L 1963 Magnesium deficiency in gastrointestinal fluid loss. Acta Chir Scand 306(Suppl):5-60.
39. LaSala MA, Lifdshitz F, Silverberg M, Wapnir RA, Carrera E 1985 Magnesium metabolism studies in children with chronic inflammatory disease of the bowel. J Pediatr Gastroenterol Nutr 4:75-81.
40. Nyhlin H, Dyckner T, Ek B, Wester PO 1985 Plasma and skeletal muscle electrolytes in patients with Chron's disease. J Am Coll Nutr 4:531-538.
41. Heaton FW, Fourman P 1965 Magnesium deficiency and hypocalcemia in intestinal malabsorption. Lancet 2:50-52.
42. Booth CC, Hanna S, Babouris N, MacIntyre I 1963 Incidence of hypomagnesemia in intestinal malabsorption. Br Med J 2:141-144.
43. Goldman AS, Van Fossan DD, Baird EE 1962 Magnesium deficiency in celiac disease. Pediatrics 29:948-952.
44. Smith GA, Tompkins RK 1974 Biliary magnesium loss in the postoperative patient. Arch Surg 109:77-79.
45. Dyckner T, Hallberg D, Hultman E, Wester PO 1982 Magnesium deficiency following jejunoileal bypass operations for obesity. J Am Coll Nutr 1:239-246.
46. Swenson SA Jr, Lewis JW, Seby KR 1974 Magnesium metabolism in man with special reference to jejunolileal bypass for obesity. Am J Surg 127:250-255.
47. Van Gaal L, Delvigne C, Vandewoude M, Cogge E, Vaneerdeweg W, Schoofs E, De Leeuw I 1987 Evaluation of magnesium before and after jejuno-ilial versus gastric bypass surgery for morbid obesity. J Am Coll Nutr 6:397-400.
48. Stromme JH, Steen-Hohnsen J, Hamacs K, Hofstad F, Brandtzaeg P 1981 Familial hypomagnesemia - A follow-up examination of three patients after 9 to 12 years of treatment. Pediatr Res 15:1134-1139.
49. Weir GC, Lesser PB, Drop LJ, Fischer JE, Warshaw AL 1975 The hypocalcemia of acute pancreatitis. Ann Intern Med 83:185-189.
50. Haldiman B, Goldstein DA, Akmal M, Massry SG 1980 Renal function and blood levels of divalent ion in acute pancreatitis. Miner Electrolyte Metab 3:190-199.
51. Ryzen E, Rude RK 1990 Low intracellular magnesium in patients with acute pancreatitis and hypocalcemia. West J Med 152:145-148.
52. Massry SG, Coburn JW, Chapman LW, Kleeman R 1967 Effect of NaCl infusion on urinary calcium and magnesium during reduction in their filtered loads. Am J Physiol 213: 218-224.
53. Coburn JW, Massry SG, Kleeman CR 1970 The effect of calcium infusion on renal handling of magnesium with normal and reduced glomerular filtration rate. Nephron 7:131-143.
54. McNair P, Christensen MS, Christiansen C, et al. 1982 Renal hypomagnesaemia in human diabetes mellitus: Its relation to glucose homeostasis. Eur J Clin Invest 12:81-85.
55. Quamme GA 1989 Control of magnesium transport in the thick ascending limb. Am J Physiol 256:F197-F210.
56. Quamme GA 1981 Effect of furosemide on calcium and magnesium transport in the rat nephron. Am J Physiol 241:F340-F347.
57. Zaloga GP, Chernow B, Pock A, Wood B, Zaritsky A, Zucker A 1984 Hypomagnesemia is a common complication of aminoglycoside therapy. Surg Gynecol Obstet 158:561-565.
58. Kes P, Reiner Z 1990 Symptomatic hypomagnesemia associated with gentamicin therapy. Magnes Trace Elem 9:54-60.
59. Rude, RK 1996 Magnesium disorders. In: Kokko JP, Tannen RL (eds.) Fluids and Electrolytes, 3rd Ed. W.B. Saunders Co., Philadelphia, PA, U.S.A., pp. 421-445.
60. Meyer KB, Madias NE 1994 Cisplatin nephrotoxicity. Miner Electrolyte Metab 20:201-213.
61. Lam M, Adelstein BJ 1986 Hypomagnesemia and renal magnesium wasting in patients treated with cisplatin. Am J Kidney Dis 8:164-169.
62. Buckley JE, Clark VL, Meyer TJ, Pearlman NW 1984 Hypomagnesemia after cisplatin combination chemotherapy. Arch Inter Med 144:2347-2348.
63. Allen RD, Hunnisett AG, Morris PJ 1985 Cyclosporin and magnesium. Lancet 6:1283-1284.
64. Bennett WM, Burdmann EB, Andoh T, Elzinga A, Franceschini N 1994 Nephrotoxicity of immunosuppressive drugs. Miner Electrolyte Metab 20:214-220.
65. Mendelson JH, Ogata M, Mello NK 1969 Effects of alcohol ingestion and withdrawal on magnesium states of alcoholics. Ann NY Acad Sci 169:918-933.
66. Lau K, Nichols FR, Tannen RL 1987 Renal excretion of divalent ions in response to chronic acidosis: Evidence that systemic pH is not the controlling variable. J Lab Clin Med 109:27-33.
67. Rude RK, Oldham SB, Sharp CF Jr, Singer FR 1978 Parathyroid hormone secretion in magnesium deficiency. J Clin Endocrinol Metab 47:800-806.
68. Rude RK, Oldham SB, Singer FR 1976 Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency. Clin Endocrinol 5:209-224.
69. Fatemi S, Ryzen E, Flores J, Endres DB, Rude RK 1991 Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 73:1067-1072.
70. Estep H, Shaw WA, Watlington C, Hobe R, Holland W, Tucker SG 1969 Hypocalcemia due to hypomagnesemia and reversible parathyroid hormone unresponsiveness. J Clin Endocrinol 29:842-848.
71. Levi J, Massry SG, Coburn JW, Llach F, Kleeman CR 1974 Hypocalcemia in magnesium-depleted dogs: Evidence for reduced responsiveness to parathyroid hormone and relative failure of parathyroid gland function. Metabolism 23:323-335.
72. Forbes RM, Parker HM 1980 Effect of magnesium deficiency on rat bone and kidney sensitivity to parathyroid hormone. J Nutr 110:1610-1617.
73. Freitag JJ, Martin KJ, Conrades MB, Bellorin-Font E, Teitelbaum S, Klahr S, Slatopolsky E 1979 Evidence for skeletal resistance to parathyroid hormone in magnesium deficiency. J Clin Invest 64:1238-1244.
74. ++ may result in impaired PTH secretion and PTH end-organ resistance. In: Altura B, Durlach J, and Seelig M (eds.) Magnesium in Cellular Processes and Medicine. S. Karger, Basel, Switzerland, pp. 183-195.
75. Medalle R, Waterhouse C 1973 A magnesium-deficient patient presenting with hypocalcemia and hyperphosphatemia. Ann Intern Med 79:76-79.
76. Medalle R, Waterhouse C, Hahn TJ 1976 Vitamin D resistance in magnesium deficiency. Am J Clin Nutr 29:854-858.
77. Miravet L, Ayigbede O, Carre M, Rayssiguier Y, Larvor P 1980 Lack of vitamin D action on serum calcium in magnesium deficient rats. In: Cantin M, Seelig MS (eds.) Magnesium in Health and Disease. Spectrum, New York, NY, U.S.A., pp. 281-289.
78. Rude RK, Adams JS, Ryzen E, Endres DB, Niimi II, Horst RL, Haddad JF, Singer FR 1985 Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency, J Clin Endocrinol Metab 61:933-940.
79. Kenney MA, McCoy H, Williams L 1994 Effects of magnesium deficiency on strength, mass and composition of rat femur. Calcif Tissue Int 54:44-49.
80. Rude RK, Kirchen MF, Gruber HE, Meyer MH 1997 Magnesium deficiency induces osteoporosis in the rat. Miner Electrolyte Metab (in press).
81. Reginster JY, Strause L, Deroisy R, Lecart MP, Saltman P, Franchimont P 1989 Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 8:106-109.
82. Cohen L 1988 Recent data on magnesium and osteoporosis. Magnes Res 1:85-87.
83. Cohen L, Laor A 1990 Correlation between bone magnesium concentration and magnesium retention in the intravenous magnesium load test. Magnes Res 3:271-274.
84. Cohen L, Laor A, Kitzes R 1983 Magnesium malabsorption in postmenopausal osteoporosis. Magnesium 2:139-143.
85. Stendig-Lindenberg G, Tepper R, Leichter I 1993 Trabecular bone density in a two year controlled trial of personal magnesium in osteoporosis. Magnes Res 6:155-163.
86. Manicourt DH, Orloff S, Brauman J, Schoutens A 1981 Bone mineral content of the radius: Good correlations with physiocochemical determinations in iliac crest trabecular bone of normal and osteoporotic subjects. Metabolism 30:57-62.
87. Angus RM, Sambrook PN, Pockock NA, Eisman JA 1988 Dietary intake and bone mineral density. Bone Miner 4: 265-277.
88. Freudenheim JL, Johnson NE, Smith EL 1986 Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: Longitudinal and cross-sectional analysis. Am J Clin Nutr 44:863-876.
89. Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM 1985 The relationship between diet and bone mineral content of multiple skeletal sites in elderly women living in Hawaii. Am J Clin Nutr 42:877-888.
90. Tucker K, Kiel DP, Hannan MT, Felson DT 1995 Magnesium intake is associated with bone mineral density elderly women. J Bone Miner Res 10:S466.
91. Abraham GE, Grewal H 1990 A total dietary program emphasizing magnesium instead of calcium: Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 35:503-507.
92. Rude RK 1996 Magnesium metabolsim. In: Bilezikian JB, Raisz L, Rodau G, Markovac J (eds.) Principles of Bone Biology, 1st Ed. Academic Press, San Diego, CA, U.S.A., pp. 277-293.
93. Rude RK, Olerich M 1996 Magnesium deficiency: Possible role in osteoporosis associated with gluten sensitive enteropathy. Osteoporosis Int 6:453-461.
94. Sojka JL, Weaver CM 1995 Magnesium supplementation and osteoporosis. Nutr Rev 53:71-74.
95. Whang R, Hampton EM, Whang DD 1994 Magnesium homeostasis and clinical disorders of magnesium deficiency. Ann Pharmacol 28:220-226.
96. Wacker WEC, Moore FD, Ulmer DD, Vallee BL 1962 Normocalcemic magnesium deficiency tetany. JAMA 180: 161-163.
97. Mordes JP, Wacker WEC 1978 Excessive magnesium. Pharmacol Rev 29:273-300.
98. Jenkinson DH 1957 The nature of antagonism between calcium and magnesium ions at the neuromuscular junction. J Physiol 138:434-444.
99. Augustine GJ, Charlton MP, Smith SJ 1987 Calcium action in synaptic transmitter release. Annu Rev Neurosci 10:633-693.
100. 2+ and adenine nucleotides. Biochemistry 25:236-244.
101. 2+ that activates hydrolysis of the phosphoenzyme. J Biol Chem 257:426-431.
102. Whang R, Flink EB, Dyckner T, Wester PO, Aikawa JK, Ryan MP 1985 Magnesium depletion as a cause of refractory potassium repletion. Arch Intern Med 145:1686-1689.
103. Whang R, Morosi HJ, Rodgers D, Reyes R 1967 The influence of sustained magnesium deficiency on muscle potassium repletion. J Lab Clin Med 70:895-902.
104. + pump. Am J Physiol 264:C457-C463.
105. Dyckner T, Wester PO 1978 The relation between extra-and intracellular electrolytes in patients with hypokalemia and/or diuretic treatment. Acta Med Scand 204:269-282.
106. Shils ME 1969 Experimental human magnesium depletion. Medicine 48:61-82.
107. Dorup I 1994 Magnesium and potassium dificiency: Its diagnosis, occurrence and treatment in diuretic therapy and its consequences for growth, protein synthesis and growth factors. Acta Physiol Scan 150:7-55.
108. Seelig MS 1969 Electrocardiographic pattern of magnesium depletion appearing in alcoholic heart disease. Ann NY Acad Sci 162:906-917.
109. Hollifield JW 1987 Magnesium depletion, diuretics, and arrythmias. Am J Med 82(Suppl 3A):30-37.
110. Chadda KD, Lichstein E, Gupta P 1973 Hypomagnesemia and refractory cardiac arrythmia in a non-digitalized patient. Am J Cardiol 31:98-100.
111. Levine SR, Crowley TJ, Hai HA 1982 Hypomagnesemia and ventricular tachycardia. Chest 81:244-247.
112. Loeb HS, Pietras RJ, Gunnar RM, Tobin JR 1968 Paroxysmal ventricular fibrillation in two patients with hypomagnesemia. Circulation 37:210-221.
113. Iseri LT, Freed J, Bures AR 1975 Magnesium deficiency and cardiac disorders. Am J Med 58:837-846.
114. Dyckner T 1980 Serum magnesium in acute myocardial infarction. Acta Med Scand 207:59-66.
115. White RE, Hartzell HC 1989 Magnesium ions in cardiac function. Biochem Pharm 38:859-867.
116. Morton BC, Nair RC, Smith FM, McKibben TG, Poznanski WJ 1984 Magnesium therapy in actue myocardial infarction - A double-blind study. Magnesium 3:346-352.
117. Smith LF, Heagerty AM, Bing RF, Barnett DB 1986 Intravenous infusion of magnesium sulfate after acute myocardial infarction: Effects on arrythmia and mortality. Int J Cardiol 12:175-180.
118. Rasmussen HS, Suenson M, McNair P, Norrogard P, Balslev S 1987 Magnesium infusion reduces the incidence of arrythmias in acute myocardial infarction: A double-blind, placebo-controlled study. Clin Cardiol 10:351-356.
119. Cohen L, Kitzes R 1985 Magnesium sulfate and digitalis-toxic arrythmias. JAMA 249:2808-2810.
120. Burch GE, Giles TD 1977 The importance of magnesium deficiency in cardiovascular disease. Am Heart J 94:649-657.
121. O'Rourke B 1993 Ion channels as sensors of cellular energy. Biochem Pharmacol 46:1103-1112.
122. + channel. Annu Rev Physiol 53:289-298.
123. Laban E, Charbon GA 1986 Magnesium and cardiac arrhythmias: nutrient or drug? J Am Coll Nutr 5:521-532.
124. Ghani MF, Rabah M 1977 Effect of magnesium chloride on electrical stability of the heart. Am Heart J 94:649-657.
125. Kulick DL, Hong R, Ryzen E, Rude RK, Rubin JN, Elkayam U, Rahimtoola SH, Bhandari AK 1988 Electrophysiologic effects of intravenous magnesium in patients with normal conduction systems and no clinical evidence of significant cardiac disease. Am Heart J 115:367.
126. Teo KK, Yusuf S, Collins R, Held PH, Peto R 1991 Effects of intravenous magnesium in suspected acute myocardial infarction: Overview of randomised trials. Br Med J 303:1499-1503.
127. Woods KL, Fletcher S, Roffe C, Haider Y 1992 Intravenous magnesium sulphate in suspected acute myocardial infarction: Result of the second Leicester Intravenous Magnerisum Intervention Trial (LIMIT-2). Lancet 339:1553-1558.
128. Woods DL 1994 Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: The second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 343:816-819.
129. 1995 ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. Lancet 345:669-685.
130. Joffres MR, Reed DM, Yano K 1987 Relationship of magnesium intake and other dietary factors to blood pressure: The Honolulu heart study. Am J Clin Nutr 45:469-475.
131. Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA 1995 Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: The ARIC study. J Clin Epidemiol 48:927-940.
132. Witteman JCM, Willett WC, Stampfer MJ, Colditz GA, Sacks FM, Speizer FE, Rosner B, Hennekens CH 1989 A prospective study of nutritional factors and hypertension among US women. Circulation 80:1320-1327.
133. Albert DB, Morita Y, Iseri LT 1958 Serum magnesium and plasma sodium levels in essential hypertension. Circulation 17:761-764.
134. Gadallah M, Massry SG, Bigazzi R, Horst RL, Eggena P, Campese VM 1991 Intestinal absorption of calcium and calcium metabolism in patients with essential hypertension and normal renal function. Am J Hypertens 4:404-409.
135. Resnick LM, Gupta RK, Laragh JH 1984 Intracellular free magnesium in erythrocytes of essential hypertension: Relation to BP and serum divalent cations. Proc Natl Acad Sci USA 81:6511-6515.
136. Resnick L, Gupta R, Bhargara K 1991 Cellular ions in hypertension, diabetes and obesity: a nuclear magnetic resonance spectroscopic study. Hypertension 17:951-957.
137. Dyckner T, Wester PO 1983 Effect of magnesium on blood pressure. Br Med J 286:1847-1849.
138. Geleijhnse JM, Witteman JC, Bak AA, den Breeijen JH, Grobbee DE 1994 Reduction in blood pressure with a low sodium, high potassium, high magnesium salt in older subjects with mild to moderate hypertension. Br Med J 309:436-440.
139. Witteman JC, Grobbee DE, Derkx FH, Bouillon R, de Bruijn AM, Hofman A 1994 Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension. Am J Clin Nutr 60:129-135.
140. Sachs FM, Brown LE, Appel L, Borhani NO, Evans D, Whelton P 1995 Combinations of potassium, calcium and magnesium supplements in hypertension. Hypertension 26:950-956.
141. Yamamoto ME, Applegate WB, Klag MJ, Borhani NO, Cohen JD, Kirchner KA, Lakatos E, Sacks FM, Taylor JO, Hennekens CH 1995 Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure: Results from Phase I of the Trials of Hypertension Prevention. Ann Epidemiol 5:96-107.
142. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhause MM, Lin PH, Karanja NI 1997 A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 336: 1117-1124.
143. Nadler JL, Goodson S, Rude R 1987 Evidence that prostacyclin mediates the vascular action of magnesium in humans. Hypertension 9:379-383.
144. Altura BM, Altura BT 1986 Magnesium-calcium interrelationship in vascular smooth muscle. Mag Bull 8:338-350.
145. Rude R, Manoogian C, Ehrlich L, DeRusso P, Ryzen E, Nadler J 1989 Mechanisms of blood pressure regulation by magnesuim in man. Magnesium 8:266-273.
146. Hwang D, Yen C, Nadler J 1992 Effect of extracellular Mg on platelet activation and intracellular magnesium on platelet activation and intracellular calcium mobilization. Am J Hypertension 5:700-706.
147. Nadler J, Malayan S, Luong H, Shaw S, Natarajan RD, Rude K 1992 Evidence that intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care 15:835-841.
148. 2+. J Clin Invert 89:1988-1994.
149. Neri LC, Johansen HL 1978 Water hardness and cardiovascular mortality. Ann NY Acad Sci 304:203-219.
150. Altura BT, Brust M, Bloom S, Barbour RL, Stempak JG, Altura BM 1990 Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proc Natl Acad Sci USA 87:1840-1844.
151. Britton WM, Stokstad ELR 1970 Aorta and other soft tissue calcification in the magnesium-deficient rat. J Nutr 100: 1501-1506.
152. Vitale JJ, White PL, Nakamura M, Hegsted DM, Zamcock N, Hellerstein EE 1957 Interrelationships between experimental hypercholesteremia, magnesium requirement and experimental atherosclerosis. J Exp Med 106:757-766.
153. Rayssiguier Y, Gueux E 1986 Magnesium and lipids in cardiovascular disease. J Am Coll Nutr 5:507-519.
154. Lowenstein FW, Stanton MF 1986 Serum magnesium levels in the United States, 1971-1974. J Am Coll Nutr 5:399-414.
155. Wong ET, Rude RK, Singer FR, Shaw ST 1983 A high A high prevalance of hypomagnesemia and hypermagnesemia in hospitalized patients. Am J Clin Pathol 79:348-352.
156. Quamme GA 1993 Laboratory evaluation of magnesium status. Clin Lab Med 13:209-223.
157. Ryan MP, Ryan MF, Counihan TB 1981 The effect of diuretics on lymphocyte magnesium and potassium. Acta Med Scand 647:153-161.
158. Ryzen E, Wagers PW, Singer FR, Rude RK 1985 in a medical ICU population. Crit Care Med 13:19-21.
159. Ryzen E, Elkayam U, Rude RK 1986 Low blood mononuclear cell magnesium in intensive cardiac care unit patients. Am Heart J 111:475-480.
160. Rude RK, Stephen A, Nadler J 1991 Determination of red blood cell intracellular free magnesium by nuclear magnetic resonance as an assessment of magnesium depletion. Magnes Trace Elem. 10:117-121.
161. 2+ in whole blood, serum and plasma. Meth Find Exp Clin Pharmacol 14:297-304.
162. Minouni FB 1996 The ion-selective magnesium electrode: A new tool for clinicians and investigators. J Am Coll Nutr 15:4-5.
163. Ryzen E, Elbaum N, Singer FR, Rude RK 1985 Parenteral magnesium tolerance testing in the evaluation of magnesium deficiency. Magnesium 4:137-147.
164. Gulletad L, Dolva LO, Waage A, Falch D, Gagerthun H, Kjekshus J 1992 Magnesium deficiency diagnosis by an intravenous loading test. Scan J Clin Lab Invest 52:245-253.
165. Martin BJ 1990 The magnesium load test: Experience in elderly subjects. Aging 2:291-296.
166. Gullestad L, Nes M, Ronnenberg R, Midtvedt K, Falch D, Kjekshsu J 1994 Magnesium status in healthy free-living elderly Norwegians. J Am Nutr 13:45-50.
167. Flink EB 1969 Therapy of magnesium deficiency. Ann NY Acad Sci 162:901-905.
168. Ryzen E 1989 Magnesium homeostasis in critically ill patients. Magnesium 8:201-212.
169. Massry SG 1980 Managing disorders of serum magnesium concentration. Drug Ther 43-52.