Renal toxicity of the neuron-blocking and mitochondriotropic agent m-iodobenzylguanidine

Cancer Chemotherapy and Pharmacology

Volumn 42, Issue 1, 1998, Pages 37-45

  Kuin, Annemieke ^a   Aalders, Marjanka ^a   Van Der Valk, Martin A ^a   Frey, Armin ^b   Schmidt, Harald H H W ^b   Smets, Lou A ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Bioamines; Kidney; MIBG; Mitochondrial respiration; NOS

Indexed keywords

(3 IODOBENZYL)GUANIDINE; BENZYLGUANIDINE; CYPROHEPTADINE; DIURETIC AGENT; EDETATE CHROMIUM CR 51; GLUCOSE; GUANIDINE DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; PRAZOSIN; RUBIDIUM 86; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; HISTOLOGY; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY TUBULE CELL; LACTATE BLOOD LEVEL; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

3-IODOBENZYLGUANIDINE; ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; GLUCOSE; KIDNEY; MALE; MICE; MICE, INBRED C3H; NITRIC OXIDE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0031955793     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050782     Document Type: Article

References (27)

1. Baylis C, Slangen B, Hussain S, Weaver C (1996) Relationship between basal NO release and cyclooxygenase products in the normal rat kidney. Am J Physiol 271: R1327
2. Gabr A, Kuin A, Aalders M, El-Gawly H, Smets LA (1997) Cellular pharmacokinetics and cytotoxicity of camptothecin and topotecan at normal and acidic pH. Cancer Res 57: 4811
3. Hoefnagel CA, Voûte PA, Kraker J de, Marcuse H (1987) Radionuclide diagnosis and therapy of neural crest tumors using iodine-131 metaiodobenzylguanidine. J Nucl Med 28: 308
4. Hofmann H, Schmidt HH (1995) Thiol dependence of nitric oxide synthase. Biochemistry 34: 13443
5. Horak E, Hopfer SM, Sunderman FW (1981) Spectrophotometric assay for urinary N-acetyl-β-D-glucosaminidase activity. Clin Chem 27: 1180
6. Jacques S, Tobes MC, Sisson JC (1987) Sodium dependency of uptake of norepinephrine and m-iodobenzylguanidine into cultured human pheochromocytoma cells: evidence for Uptake-one. Cancer Res 47: 3920
7. Kuin A, Smets LA, Volk T, Paans A, Adams G, Atema A, Jähde E, Mass A, Rajewsky MF, Visser G, Wood P (1994) Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Res 54: 3785
8. Loesberg C, Rooij H van, Smets LA (1990) Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for choleratoxin that interferes with cellular mono(ADP-ribosylation). Biochim Biophys Acta 1037: 92
9. Loesberg C, Rooij H van, Nooijen WJ, Meijer AJ, Smets LA (1990) Impaired mitochondrial respiration and stimulated glycolysis by m-iodobenzylguanidine (MIBG). Int J Cancer 46: 276
10. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin Phenol reagent. J Biol Chem 193: 265
11. Post JG, Poele JAM te, Oussoren YG, Stewart FA (1993) Bladder damage in mice after single and repeated intravesical instillations of mitomycin C or doxorubicin. J Urol 150: 1965
12. Puschett JB (1987) Do calcium channel blockers protect against renal ischemia? Am J Nephrol 7: 49
13. Rutgers M, Tytgat GAM, Verwijs-Janssen M, Buitenhuis C, Voûte PA, Smets LA (1993) Uptake of the neuron-blocking agent meta-iodobenzylguanidine and serotonin by human platelets and neuro-adrenergic tumour cells. Int J Cancer 54: 290
14. Sapirstein LA (1958) Regional blood flow by fractional distribution of indicators. Am J Physiol 193: 161
15. Smets LA, Bout B, Wisse J (1988) Cytotoxic and antitumor effects of the norepinephrine analogue meta-iodo-benzylguanidine (MIBG). Cancer Chemother Pharmacol 21: 9
16. Smets L, Metwally EAG, Knol E, Martens M (1988) Potentiation of glucocorticoid-induced lysis in refractory and resistant leukemia cells by inhibitors of ADP-ribosylation. Lenk Res 12: 737
17. Smets LA, Loesberg C, Janssen M, Rooij H van (1990) Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis. Biochim Biophys Acta 1054: 49
18. Smets LA, Janssen M, Rutgers M, Ritzen K, Buitenhuis C (1991) Pharmacokinetics and intracellular distribution of the tumor-targeted radiopharmaceutical m-iodobenzylguanidine in SK-N-SH neuroblastoma and PC-12 pheochromocytoma cells. Int J Cancer 48: 609
19. Stacpoole PW (1993) Lactic acidosis. Endocrinol Metab Clin North Am 22: 22146
20. Stewart FA, Luts A, Begg AC (1987) Tolerance of previously irradiated mouse kidneys to cis-diamminedichloroplatinum(II). Cancer Res 47: 1016
21. Taal BG, Hoefnagel CA, Valdes Olmos RA, Boot H, Beijnen JH (1996) Palliative effect of metaiodobenzylguanidine in metastatic carcinoid tumors. J Clin Oncol 14: 1829
22. 131I-MIBG scanning and its potential benefit in the treatment of metastatic carcinoid (abstract). Eur J Gastroenterol Hep 8: A36
23. Van den Berg J, Smets L, Rutgers M, Grummels A, Fokkens R, Jonkergauw P, Rooij H van (1997) Chemical characterization and comparative cellular effects of meta-iodobenzyl guanidine (MIBG) and benzyl guanidine (BG). Cancer Chemother Pharmacol 40: 131
24. Van Geel IPJ, Oppelaar H, Oussoren YG, Stewart FA (1994) Changes in blood flow of mouse tumours after photodynamic therapy. Int J Cancer 56: 224
25. Wafelman AR, Nortier YLM, Rosing H, Maessen HJM, Taal BG, Hoefnagel CA, Macs RAA, Beijnen JH (1995) Renal excretion of meta-iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearnace. Nucl Med Commun 16: 767
26. 131I]iodobenzylguanidine. J Nucl Med 21: 349
27. Wilcox CS, Welch WJ, Murad F, Gross SS, Taylor G, Levi R, Schmidt HHHW (1992) Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci USA 89: 11993