Pharmacologic profile of TA-606, a novel angiotensin II-receptor antagonist in the rat

Journal of Cardiovascular Pharmacology

Volumn 31, Issue 4, 1998, Pages 568-575

  Hashimoto, Yoshihiro ^a   Ohashi, Rikiya ^a   Kurosawa, Yukie ^a   Minami, Kouichi ^a   Kaji, Hidehumi ^a   Hayashida, Koukichi ^a   Narita, Hiroshi ^a   Murata, Sakae ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Angiotensin II receptor antagonist; AT1; In vivo; TA 606

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 2 PROPYL 3 [2' (1H TETRAZOLE 5 YL)BIPHENYL 4 YL]METHYL 5 ACETYL 4,5,6,7 TETRAHYDROIMIDAZO[4,5 C]PYRIDINE 4 CARBOXYLIC ACID DISODIUM SALT; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; DEOXYCORTICOSTERONE ACETATE; IMIDAPRIL; LOSARTAN; T 606; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; HEART RATE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; LONG TERM CARE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; DESOXYCORTICOSTERONE; HEART RATE; HYPERTENSION, RENAL; IMIDAZOLES; IMIDAZOLIDINES; LOSARTAN; MALE; PRODRUGS; PYRIDINES; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; TETRAZOLES; TIME FACTORS;

EID: 0031955613     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199804000-00015     Document Type: Article

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