Status of Cys residues in the covalent structure of botulinum neurotoxin types A, B, and E

Journal of Protein Chemistry

Volumn 17, Issue 3, 1998, Pages 187-196

  Antharavally, Babu ^a   Tepp, William ^a   DasGupta, Bibhuti R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Botulinum neurotoxin; Cys residues; Disulfide bonds; Free sulfhydryl groups

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); AMMONIUM SULFATE; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN E; CYSTEINE; DISULFIDE; EDETIC ACID; GUANIDINE; IODOACETAMIDE; NEUROTOXIN; REDUCING AGENT; UNCLASSIFIED DRUG;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CLOSTRIDIUM BOTULINUM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; NONHUMAN; PRECIPITATION; PROTEIN STRUCTURE; STORAGE; TITRIMETRY;

EID: 0031954673     PISSN: 02778033     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022572332150     Document Type: Article

References (38)

1. Apodaca, G., Cardone, M. H., Whiteheart, S. W., DasGupta, B. R., and Mostov, K. E. (1996). EMBO J. 15, 1471-1481.
2. Bandyopadhyay, S., Clark, A. W., DasGupta, B. R., and Sathyamoorthy, V. (1987). J. Biol. Chem. 262, 2660-2663.
3. Banerjee, A., Martin, T. F. J., and DasGupta, B. R. (1993). Neurosci. Lett. 164, 93-96.
4. Beers, W. H., and Reich, E. (1969). J. Biol. Chem. 244, 4473-4479.
5. Bittner, M. A., DasGupta, B. R., and Holz, R. W. (1989). J. Biol. Chem. 264, 10354-10360.
6. Bizzini, B., Blass, J., Turpin, A., and Raynaud, M. (1970). Eur. J. Biochem. 17, 100-105.
7. Creighton, T. E. (1992). In Protein Folding (Creighton, T. E., ed.), Freeman, New York, pp. 301-351.
8. DasGupta, B. R. (1994). In Therapy with Botulinum Toxin (Janokovic, J., and Halett, M., eds), Marcel Dekker, New York, pp. 15-39.
9. DasGupta, B. R., and Sathyamoorthy, V. (1984). Toxicon 22, 415-424.
10. DasGupta, B. R., and Sugyiama, H. (1972). Biochem. Biophys. Res. Commun. 48, 108-112.
11. DasGupta, B. R., and Sugiyama, H. (1976). Infect. Immun. 14, 680-686.
12. DasGupta, B. R., and Sugiyama, H. (1978). Am. Soc. Microbiol. (abst.) 1978, 25.
13. DasGupta, B. R., and Woody, M. (1984). Toxicon 22, 312-315.
14. De Paiva, A., Poulain, B., Lawrence, G. W., Shone, C. C., Taue, L., and Dolly, J. O. (1993). J. Biol. Chem. 268, 20838-20844.
15. Ellman, G. L. (1959). Arch. Biochem. Biophys. 82, 70-77.
16. Evans, D. M., Williams, R. S., Shone, C. C., Hambleton, P., Melling, J., and Dolly, J. O. (1986). Eur. J. Biochem. 154, 409-416.
17. Fernandez Diez, M. J., Osuga, D. T., and Feeney, R. E. (1964). Arch. Biochem. Biophys. 107, 449-58.
18. Gilbert, H. F. (1994). In Mechanisms of Protein Foldings (Pain, R. H., ed.), IRL Press, Oxford, pp. 104-136.
19. Gimenez, J. A., and DasGupta, B. R. (1992). J. Protein Chem. 11, 255-264.
20. Inoue, K., Fujinaga, Y., Watanabe, T., Ohyama, T., Takeshi, K., Moriishi, K., Nakajima, H., Inoue, K., and Oguma, K. (1996). Infect. Immun. 64, 1589-1594.
21. Kistner, A., and Habermann, E. (1992). N.S. Arch. Pharmac. 345, 227-234.
22. Kistner, A., Sanders, D., and Habermann, E. (1993). Toxicon 31, 1423-1434.
23. Knox, J. N., Brown, W. P., and Spero, L. (1970). Biochim. Biophys. Acta 214, 350-354.
24. Kozaki, S., and Sakaguchi, G. (1975). Infect. Immun. 11, 932-936.
25. Krieglstein, K. G., Henschen, A., Weller, U., and Habermann, E. (1990). Eur. J. Biochem. 188, 39-45.
26. Krieglstein, K. G., DasGupta, B. R., and Henschen, A. H. (1994). J. Protein Chem. 13, 49-57.
27. Leslie, J., Williams, D. L., and Gorin, G. (1962a). Anal. Biochem. 3, 257-263.
28. Leslie, J., Butler, L. G., and Gorin, G. (1962b). Arch. Biochem. Biophys. 99, 86-92.
29. Montecucco, C., and Schiavo, G. (1995). Q. Rev. Biophys. 28, 423-472.
30. Oblatt-Montal, M., Yamazaki, M., Nelson, R., and Montal, M. (1995). Protein Sci. 4, 1490-1497.
31. Riddles, P. W., Blakeley, R. L., and Zerner, B. (1983). In Methods in Enzymology, Vol. 92, (Hirs, C. H. W., and Timasheff, S. N., eds.), Academic Press, New York, pp. 49-60.
32. Sathyamoorthy, V., and DasGupta, B. R. (1985). J. Biol Chem. 250, 10461-10466.
33. Schiavo, G., Boquet, P., DasGupta, B. R., and Montecucco, C. (1990a). J. Physiol. (Paris) 84, 180-187.
34. Schiavo, G., Papini, E., Genna, G., and Montecucco, C. (1990b). Infect. Immun. 48, 4136-4141.
35. Schmidt, J. J., and Bostian, K. A. (1995). J. Protein Chem. 14, 703-708.
36. Shone, C. C., Quinn, C. P., Wait, R., Hallis, B., Fooks, S. G., and Hambleton, P. (1993). Eur. J. Biochem. 217, 965-971.
37. Sugiyama, H., DasGupta, B. R., and Yang, K. H. (1973). Proc. Soc. Exp. Biol. Med. 143, 589-591.
38. Whelan, S. M., Elmore, M. J., Bodsworth, N. J., Brehm, J. K., Atkinson, T., and Minton, N. P. (1992). Appl. Environ. Microbiol. 48, 2345-2354.