Determination of particle size in a fluidized bed granulator with a near infrared set-up

Pharmacy and Pharmacology Communications

Volumn 4, Issue 2, 1998, Pages 73-75

  Rantanen, Jukka ^a   Yliruusi, Jouko ^a  

^a Pharmaceutical Technology Division   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG GRANULATION; FLUIDIZED BED; PARTICLE SIZE; REFLECTOMETRY;

EID: 0031952578     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Ciurczak, E. W., Torlini, R. P., Demkowicz, M. P. (1986) Determination of particle size of pharmaceutical raw materials using near-infrared reflectance spectroscopy. Spectroscopy 1: 36-39
2. Davies, W. L., Gloor, W. T. (1971) Batch production of pharmaceutical granulations in a fluidized bed I: effects of process variables on physical properties of final granulation. J. Pharm. Sci. 60: 1869-1873
3. Frake, P. Greenhalgh, D., Grierson, S. M., Hempenstall, J. M., Rudd, D. R. (1997) Process control and end-point determination of a fluid bed granulation by application of near infrared spectroscopy. Int. J. Pharm. 151: 75-80
4. List, K., Steffens, K.-J. (1996) Überwachung und Steuerung von Granulationsprozessen mit Hilfe der Nach-Infrarot-Spektroskopie. Pharm. Ind. 58: 347-353
5. Merkku, P., Yliruusi, J., Hellén L. (1992) Testing of an automated laboratory scale fluidized bed granulator with different bed loads. Acta Pharm. Fenn. 101: 173-180
6. Niskanen, T., Yliruusi, J., Niskanen, M., Kontro O. (1990) Granulation of potassium chloride in instrumented fluidized bed granulator - Part I: effect of flow rate. Acta Pharm. Fenn. 99: 13-22
7. Schæfer, T., Wørts, O. (1978) Control of fluidized bed granulation: V. Factors affecting granule growth. Arch. Pharm. Chem. Sci. Ed. 6: 69-82
8. Watano, S., Miyanami, K. (1995) Image processing for on-line monitoring of granule size distribution and shape in fluidized bed granulation. Powder Technol. 83: 55-60
9. Watano, S., Sato, Y., Miyanami, K. (1995) Application of fuzzy logic to moisture control in fluidized bed granulation. J. Chem. Eng. Jpn 28: 282-287
10. Watano, S., Sato, Y., Miyanami, K. (1996) Control of granule growth in fluidized bed granulation by an image processing system. Chem. Pharm. Bull. 44: 1556-1560