Metabolism and pharmacokinetics of sucrose acetate isobutyrate (SAIB) and sucrose octaisobutyrate (SOIB) in rats, dogs, monkeys or humans: A review

Food and Chemical Toxicology

Volumn 36, Issue 2, 1998, Pages 95-99

  Reynolds, R C ^a,b  

^a EASTMAN KODAK COMPANY   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD ADDITIVE; SUCROSE ACETATE ISOBUTYRATE; SUCROSE ESTER DERIVATIVE; UNCLASSIFIED DRUG;

BEVERAGE; DOG; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; FOOD SAFETY; HUMAN; MONKEY; NONHUMAN; REVIEW;

ANIMALS; BILE; CARBONATED BEVERAGES; DOGS; DRUG APPROVAL; FOOD ADDITIVES; HAPLORHINI; HUMANS; INTESTINAL ABSORPTION; RATS; SPECIES SPECIFICITY; SUCROSE;

CANIS FAMILIARIS;

EID: 0031951397     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(97)00123-3     Document Type: Review

References (8)

1. Noker P. E., Kalin J. R., McCarthy D. J., El Dareer S. M. and Chappel C. I. (1986) Disposition of sucrose octaisobutyrate in rats, dogs and monkeys. Food and Chemical Toxicology 24, 1287-1294.
2. Phillips J. C., Kingsnorth J., Rowland I., Gangolli S. D. and Lloyd A. G. (1976) Studies on the metabolism of sucrose acetate isobutyrate in the rat and man. Food and Cosmetics Toxicology 14, 375-380.
3. Reynolds, R. C. (1963) The in vivo absorption of sucrose acetate isobutyrate from the intestine of the rat. Unpublished report, Eastman Kodak Company, 26 March.
4. 14C(U) acetate isobutyrate. Unpublished report, Eastman Kodak Company, 31 January.
5. 14C(U) acetate isobutyrate in humans, rats and dogs. Journal of Agricultural and Food Chemistry 22, 1084-1088.
6. Reynolds R. C. and Chappel C. I. (1998) Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988. Food and Chemical Toxicology 36, 81-93.
7. Terzioglu M. and Eröz (1949) The fate of subcutaneously injected sucrose in the rabbit. Archives Internationales de Pharmacodynamie et de Therapie 80, 269-275.
8. Weser E., Sleisenger M. H., Dickstein M. and Bartley F. H. (1967) Metabolism of circulating disaccharides in man and rat. Journal of Clinical Investigation 46, 499-505.