Specific insulin and proinsulin concentrations in nondiabetic South Indians

Metabolism: Clinical and Experimental

Volumn 47, Issue 2, 1998, Pages 230-233

  Snehalatha, C ^a   Ramachandran, A ^b   Satyavani, K ^b   Vijay, V ^b   Haffner, S M ^b  

^a Diabetes Research Centre Tamil Nadu   (India)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROINSULIN; TRIACYLGLYCEROL;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; BODY MASS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INDIA; INSULIN BLOOD LEVEL; INSULIN METABOLISM; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL;

EID: 0031951036     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90226-8     Document Type: Article

References (23)

1. Snehalatha C, Ramachandran A, Vijay V, et al: Differences in plasma insulin responses in urban and rural Indians: A study in Southern-Indians. Diabet Med 11:445-448, 1994
2. Mohan V, Sharp PS, Cloke HR, et al: Serum immunoreactive insulin responses to a glucose load in Asian Indian and European type 2 (non insulin dependent) diabetic patients and control subjects. Diabetologia 29:235-237, 1986
3. McKeigue PM, Shah B, Marmot MG: Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337:282-286, 1991
4. UK Prospective Diabetes Study Group: UK Prospective Diabetes Study. XII. Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetes patients at diagnosis of diabetes. Diabet Med 11:670-677, 1994
5. Nagi DK, Hendra TJ, Ryle AJ, et al: The relationships of concentrations of insulin, intact proinsulin and 32-33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin dependent) diabetic subjects. Diabetologia 33:532-537, 1990
6. Sharp PS, Mohan V, Levy JC, et al: Insulin resistance in patients of Asian Indian and European origin with non-insulin dependent diabetes. Horm Metab Res 19:84-85, 1987
7. Porte D, Kahn SE: Hyperproinsulinaemia and amyloid in NIDDM. Clues to etiology of islet cell dysfunction? Diabetes 38:1333-1336, 1989
8. Ward WK, LaCava EC, Paquette TL, et al: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin dependent) diabetes mellitus and in experimental insulin-resistance. Diabetologia 30:698-702, 1987
9. Saad MF, Kahn SE, Nelson RG, et al: Disproportionately elevated proinsulin in Pima Indians with noninsulin dependent diabetes mellitus. J Clin Endocrinol Metab 70:1247-1253, 1990
10. Clark PM, Levy JC, Cox L, et al: Immunoradiometric assay of insulin, intact proinsulin and 32,33 split proinsulin and radioimmunoassay of insulin in diet treated type 2 (non insulin dependent) diabetic subjects. Diabetologia 35:469-474, 1992
11. Haffner SM, Bowsher RR, Mykkanen L, et al: Proinsulin and specific insulin concentration in high and low risk populations for NIDDM. Diabetes 43:1490-1493, 1994
12. Yoshioka N, Kuzuya T, Matsuda A, et al: Serum proinsulin levels at fasting and after oral glucose load in patients with type II (noninsulin dependent) diabetes mellitus. Diabetologia 31:355-360, 1988
13. Reaven GM, Chen Y-DI, Hollenbeck CB, et al: Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab 76:44-48, 1993
14. Davies MJ, Rayman G, Gray IP, et al: Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance. Diabet Med 10:313-320, 1993
15. Shiraishi I, Iwamoto Y, Kuzuya T, et al: Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia 34:737-741, 1991
16. Mykkanen L, Laakso M, Uusitupa M, et al: Prevalence of diabetes and impaired glucose tolerance in elderly subjects and their association with obesity and family history of diabetes. Diabetes Care 13:1099-1105, 1990
17. Mykkanen L, Haffner SM, Kuusisto J, et al: Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia 38:1176-1182, 1995
18. Haffner SM, Stern MP, Miettinen H, et al: Higher proinsulin and specific insulin are both associated with a parental history of diabetes in non-diabetic Mexican American subjects. Diabetes 44:1156-1160, 1995
19. WHO Study Group: Diabetes mellitus. World Health Organ Tech Rep Ser 727:94-98, 1985
20. Herbert V, Lau KS, Gottilieb CW, et al: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384, 1965
21. Starr JI, Rubenstein AH: Metabolism of endogenous proinsulin and insulin in man. J Clin Endocrinol Metab 38:305-308, 1974
22. Duckworth WC, Kitabchi AE, Heinemann M: Direct measurement of plasma proinsulin in normal and diabetic subjects. Am J Med 53:418-427, 1972
23. Haffner SM, Mykkanen L, Stern MP, et al: Relationship of proinsulin and insulin for cardiovascular risk factors in nondiabetic subjects. Diabetes 42:1297-1302, 1993