FEP regimen (epidoxorubicin, etoposide and cisplatin) in advanced gastric cancer, with or without low-dose GM-CSF: An Italian Trial in Medical Oncology (ITMO) study

British Journal of Cancer

Volumn 77, Issue 7, 1998, Pages 1149-1154

  Bajetta, E ^a   Di Bartolomeo, M ^a   Carnaghi, C ^a   Buzzoni, R ^a   Mariani, L ^a   Gebbia, V ^a   Comella, G ^a   Pinotti, G ^a   Ianniello, G ^a   Schieppati, G ^a   Bochicchio, A M ^a   Maiorino, L ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Gastric cancer; Growth factor; Polychemotherapy

Indexed keywords

CISPLATIN; EPIRUBICIN; ETOPOSIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; FEMALE; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MUCOSA INFLAMMATION; MULTICENTER STUDY; NAUSEA; NEPHROTOXICITY; NEUROTOXICITY; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH CANCER; SUBCUTANEOUS DRUG ADMINISTRATION; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT FAILURE; VOMITING;

EID: 0031950983     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.191     Document Type: Article

References (26)

1. Ajani JA, Roth JA, Ryan B, Putman JB, Pazdur R, Levin B, Gutterman HU and McMurtrery M (1993) Intensive preoperative chemotherapy with colony-stimulating factor for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol 11: 22-28
2. Atkinson EN and Brown BW (1985) Confidence limits for probability of response in multistage Phase II clinical trial. Biometrics 41: 741-744
3. Bajetta E, Di Bartolomeo M, De Braud F, Bozzetti F, Bochicchio AM, Comella P, Fagnani D, Farina G, Ferroni C, Franchi R, Gebbia V, Iannidlo G, Iirillo A, Pinotti G, Schieppati G, Ucci G, Visini M, Zaniboni A, Buzzoni R, Casartelli C and Nelli P (1994) Etoposide, doxorubicin and cisplatin (EAP) treatment in advanced gastric carcinoma: a multicentre study of the Italian Trials in Medical Oncology (I.T.M.O.) Group. Eur J Cancer 30: 596-600
4. Bezwoda WR, Seymour L and Dansey RD (1995) High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: A randomized trial. J Clin Oncol 13: 2483-2489
5. Di Bartolomeo M, Bajetta E, De Braud F, Bochicchio AM, Gebbia V, Bozzetti F, Doci R, Bonfanti G and Cozzaglio L (1995) Phase II study of the etoposide, leucovorin and fluoruracil combination for patients with advanced gastric cancer unsuitable for aggressive chemotherapy. Oncology 52: 41-44
6. Findlay M, Cunningham D, Norman A, Mansi J, Nicholson M, Hickish T, Nicholson V, Nash A, Sacks N, Ford H, Carter J and Hill A (1994) A Phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluoruracil (ECF). Ann Oncol 5: 609-616
7. Fischer JR, Manegold C, Bülzebruck H, Vogt-Moykopf I and Drings P (1994) Induction chemotherapy with and without recombinant human granulocyte colony-stimulating factor support in locally advanced stage IIIA/B non-small cell lung cancer. Semin Oncol 21 (suppl. 4): 20-27
8. Girling DJ, Thacher N, Clark PI and Stephens RJ (1996) Increasing the dose intensity of chemotherapy by means of granulocyte-colony stimulating factor (G-CSF). Support in the treatment of small cell lung cancer. Eur J Cancer 32: 1263-1267
9. Glimelius B, Hoffman K, Haglund U, Nyren O and Sjoden PO (1994) Initial or delayed chemotherapy with best supportive care in advanced gastric cancer. Ann Oncol 5: 189-190
10. Katz A, Gansl RC, Simon SD Gama-Rodrigues J, Waitzberg D, Bresciani CJC and Pinotti HW (1991) Phase II trial of etoposide (V), adriamycin (A), and cisplatinum (P) in patients with metastatic gastric cancer. Am J Clin Oncol 14: 357-358
11. Kelsen D (1994) The use of chemotherapy in the treatment of advanced gastric and pancreas cancer. Semin Oncol 21: 58-66
12. Macdonald JS (1992) Gastric cancer. Chemotherapy of advanced disease. Hematol Oncol 10: 37-12
13. Mantel N and Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748
14. Møller Jensen O, Esteve J, Møller H and Renard H (1990) Cancer in the European Community and its member states. Eur J Cancer 26: 1167-1256
15. Pelley RJ (1995) Role of chemotherapy in the palliation of gastrointestinal malignancies. Semin Oncol 22: 45-52
16. Preusser P, Wilke H, Achterrath W, Fink U, Lenaz L, Heinicke A, Meyer J, Meyer HJ and Buente J (1989) Phase II study with the combination etoposide, doxorubicin and cisplatin in advanced measurable gastric cancer. J Clin Oncol 7:1310-1317
17. Rougier PH, Ducreux M, Mahjoubi M, Pignon JP, Bellefqih S, Oliveira J, Bognel C, Lasser PH, Ychou M, Elias D, Cvitkovic E, Armand JP and Droz JP (1994) Efficacy of combined 5-fluorouracil and cisplatinum in advanced gastric carcinomas. A phase II trial with prognostic factor analysis. Eur J Cancer 30: 1263-1269
18. Simon R (1989) Optimal two-stage designs for phase II clinical trials. Contr Clin Trials 10: 1-10
19. Sparano JA, Schwartz EL, Salva KM, Pizzillo MF, Wadler S and Wiernik PH (1990) Phase II trial of etoposide (adriamycin), doxorubicin and cisplatin (EAP regimen) in advanced gastric cancer. Am J Clin Oncol 13: 374-378
20. Steward WP (1993) Granulocyte and granulocyte-macrophage colony stimulating factors. Lancet 342: 1153-1157
21. Suzuki T, Ochiai T, Nagata M, Koide Y, Gunji Y, Nakajima K, Yokoyama T, Kashiwabara H and Isono K (1993) High-dose chemotherapy with autologous bone marrow transplantation in the treatment of advanced gastric cancer. Cancer 72: 2537-2542
22. Wall PJ, Hodgetts J, Lomax L, Bildet F, Cour-Chabernaud V and Thatcher N (1995) Can cytotoxic dose-intensity be increased by using granulocyte colony-stimulating factor? A randomized controlled trial of lenograstim in small-cell lung cancer. J Clin Oncol 13: 652-659
23. Who/UICC (1979) Handbook for Reporting Results of Cancer Treatment. WHO Offset Publication No. 48. World Health Organization: Geneva
24. Wils J, Beiberg H, Dalesio O, Blijham G, Mulder N, Planting A, Splinter T and Duez N (1986) An EORTC gastrointestinal group evaluation of the combination of sequential methotrexate and 5-fluorouracil, combined with adriamycin in advanced measurable gastric cancer. J Clin Oncol 4: 1799-1803
25. Wittes RE (1989) Manual of Oncologic Therapeutics, pp. 627-632. JB Lippincott: Philadelphia
26. Zucker D and Wittes J (1992) Testing the effect of treatment in experiments with correlated binary outcomes. Biometrics 48: 696-710