메뉴 건너뛰기




Volumn 14, Issue 1, 1998, Pages 9-21

Beneficial effects of leflunomide on cardiac myosin-induced experimental autoimmune myocarditis in rats

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; IMMUNOMODULATING AGENT; LEFLUNOMIDE; MYOSIN; NONSTEROID ANTIINFLAMMATORY AGENT; TERIFLUNOMIDE;

EID: 0031950526     PISSN: 02559625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (53)
  • 2
    • 0029074832 scopus 로고
    • Myocarditis and idiopathic dilated cardiomyopathy
    • Brown C.A, O'Connell J.B. Myocarditis and idiopathic dilated cardiomyopathy. Am. J. Med., 99, 267, 1995
    • (1995) Am. J. Med. , vol.99 , pp. 267
    • Brown, C.A.1    O'Connell, J.B.2
  • 3
    • 0025014698 scopus 로고
    • Myocarditis: Unresolved issues in diagnosis and treatment
    • Moze S.S., Adolph R.J Myocarditis: unresolved issues in diagnosis and treatment Clin. Cardiol., 13, 69, 1990.
    • (1990) Clin. Cardiol. , vol.13 , pp. 69
    • Moze, S.S.1    Adolph, R.J.2
  • 4
    • 7344253286 scopus 로고    scopus 로고
    • The involvement of immune reactions in cardiac damage during acute myocardial infarction: Role of cell-mediated immune response
    • Dimitrijevic M., Vasiljevic Z., Vuckovic-Dekic L J., Spasic S The involvement of immune reactions in cardiac damage during acute myocardial infarction: role of cell-mediated immune response. Panminerva Med , 46, 93, 1996.
    • (1996) Panminerva Med , vol.46 , pp. 93
    • Dimitrijevic, M.1    Vasiljevic, Z.2    Vuckovic-Dekic, L.J.3    Spasic, S.4
  • 6
    • 0024439120 scopus 로고
    • Immunosuppression for dilated cardiopathy
    • O'Conell J.B Immunosuppression for dilated cardiopathy. N Engl. J. Med., 321, 1119, 1989
    • (1989) N Engl. J. Med. , vol.321 , pp. 1119
    • O'Conell, J.B.1
  • 7
    • 0026668926 scopus 로고
    • How can myocarditis be diagnosed and should it be treated?
    • Davis M.J How can myocarditis be diagnosed and should it be treated? Br. Heart J., 68, 346, 1992
    • (1992) Br. Heart J. , vol.68 , pp. 346
    • Davis, M.J.1
  • 8
    • 0018824459 scopus 로고
    • Treatment of acute inflammatory myocarditis assisted by endomyocardial biopsy
    • Mason J.W., Billingham M.E., Ricci D.R Treatment of acute inflammatory myocarditis assisted by endomyocardial biopsy. Am J Cardiol., 45, 1037, 1980.
    • (1980) Am J Cardiol. , vol.45 , pp. 1037
    • Mason, J.W.1    Billingham, M.E.2    Ricci, D.R.3
  • 9
    • 0021338337 scopus 로고
    • Acute myocarditis. Role of histological and virological examination in the diagnosis and assessment of immunosuppressive treatment
    • Daly K., Richardson P.J., Jolsen E.G., et al. Acute myocarditis. Role of histological and virological examination in the diagnosis and assessment of immunosuppressive treatment. Br. Heart J., 51, 30, 1984
    • (1984) Br. Heart J. , vol.51 , pp. 30
    • Daly, K.1    Richardson, P.J.2    Jolsen, E.G.3
  • 10
    • 0028327653 scopus 로고
    • Immune mechanisms of cardiac disease
    • Lange L.G., Schreiner G.F. Immune mechanisms of cardiac disease. N. Engl. J. Med., 330, 1129, 1994.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1129
    • Lange, L.G.1    Schreiner, G.F.2
  • 12
    • 0025620290 scopus 로고
    • Autoimmune myocarditis: A marine model
    • Beisel K.W., Traystman M.D. Autoimmune myocarditis: a marine model. Immunol Ser , 52, 267, 1990.
    • (1990) Immunol Ser , vol.52 , pp. 267
    • Beisel, K.W.1    Traystman, M.D.2
  • 14
    • 0026317198 scopus 로고
    • Cellular infiltrase, major histocompatibility antigen expression and immunopathogenic mechanisms in cardiac myosin-induced myocarditis
    • Pummerer C , Berger P, Fruhwirth M., Ofner C., Neu N Cellular infiltrase, major histocompatibility antigen expression and immunopathogenic mechanisms in cardiac myosin-induced myocarditis. Lab Invest., 65, 538, 1991.
    • (1991) Lab Invest. , vol.65 , pp. 538
    • Pummerer, C.1    Berger, P.2    Fruhwirth, M.3    Ofner, C.4    Neu, N.5
  • 15
    • 0023277757 scopus 로고
    • Coxackie-virus induced autoimmune myocarditis in mice: Cardiac mosin autoantibodies do not cross-react with the virus
    • Neu N., Craig S W, Rose N R., Alvarez F L., Beisel K.W. Coxackie-virus induced autoimmune myocarditis in mice: cardiac mosin autoantibodies do not cross-react with the virus Clin Exp. Immunol., 69, 566, 1987.
    • (1987) Clin Exp. Immunol. , vol.69 , pp. 566
    • Neu, N.1    Craig, S.W.2    Rose, N.R.3    Alvarez, F.L.4    Beisel, K.W.5
  • 17
    • 0027337655 scopus 로고
    • Epitopes shared between Coxackievirus B3 (CVB3) and normal heart tissue contribute to CVB3-induced murine myocarditis
    • Gauntt C.J., Higdon A.L., Arizpe H M , et al. Epitopes shared between Coxackievirus B3 (CVB3) and normal heart tissue contribute to CVB3-induced murine myocarditis. Clin Immunol. Immunopathol., 68, 129, 1993
    • (1993) Clin Immunol. Immunopathol. , vol.68 , pp. 129
    • Gauntt, C.J.1    Higdon, A.L.2    Arizpe, H.M.3
  • 18
    • 0028929284 scopus 로고
    • Molecular mimicry. anti-coxackievirus B3 neutralizing monoclonal antibodies, and myocarditis
    • Gauntt C J., Arizpe H.M., Higdon A L., et al. Molecular mimicry. anti-coxackievirus B3 neutralizing monoclonal antibodies, and myocarditis. J. Immunol., 154, 2983, 1995.
    • (1995) J. Immunol. , vol.154 , pp. 2983
    • Gauntt, C.J.1    Arizpe, H.M.2    Higdon, A.L.3
  • 19
    • 0025048502 scopus 로고
    • A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction
    • Kodama M., Matsumoto Y., Fujiwara M., Masani F , Izumi T , Shibata A A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction Clin. Immunol. Immunopathol., 57, 250, 1990.
    • (1990) Clin. Immunol. Immunopathol. , vol.57 , pp. 250
    • Kodama, M.1    Matsumoto, Y.2    Fujiwara, M.3    Masani, F.4    Izumi, T.5    Shibata, A.6
  • 20
    • 0021957656 scopus 로고
    • Immunopharmacological profile of a novel isoxazol derivate. HWA 486, with potential antirheumatic activity. I Disease-modifying action on adjuvant arthritis of the rat
    • Bartlett R.R., Schleyerbach R. Immunopharmacological profile of a novel isoxazol derivate. HWA 486, with potential antirheumatic activity. I Disease-modifying action on adjuvant arthritis of the rat Int. J Immunopharm , 7, 7, 1985.
    • (1985) Int. J Immunopharm , vol.7 , pp. 7
    • Bartlett, R.R.1    Schleyerbach, R.2
  • 21
    • 0025980747 scopus 로고
    • Leflunomide (HWA 486). a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
    • Bartlett R.R , Dimitrijevic M , Mattar T., et al. Leflunomide (HWA 486). a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 32, 10, 1991.
    • (1991) Agents Actions , vol.32 , pp. 10
    • Bartlett, R.R.1    Dimitrijevic, M.2    Mattar, T.3
  • 22
    • 0025202270 scopus 로고
    • Effects of leflunomide on glomerulonephntis induced by antibasement membrane antibody in rats
    • Ogawa T , Inazy M., Gotoh K Hayashi S. Effects of leflunomide on glomerulonephntis induced by antibasement membrane antibody in rats Agents Actions, 31, 321, 1990.
    • (1990) Agents Actions , vol.31 , pp. 321
    • Ogawa, T.1    Inazy, M.2    Gotoh, K.3    Hayashi, S.4
  • 23
    • 0013593986 scopus 로고
    • Efficacy of novel immunomodulators leflunomide and rapamycin in autoimmune uveitis
    • Smith-Long L., Glaser B , Weimer L K , et al Efficacy of novel immunomodulators leflunomide and rapamycin in autoimmune uveitis FASEB J., 6, A1048, 1992
    • (1992) FASEB J. , vol.6
    • Smith-Long, L.1    Glaser, B.2    Weimer, L.K.3
  • 24
    • 0029828275 scopus 로고    scopus 로고
    • A novel immunomodulating agent - Leflunomide - inhibits experimental autoimmune diabetes in mice
    • Stosic-Grujicic S , Dimitrijevic M., Bartlett R.R A novel immunomodulating agent - leflunomide - inhibits experimental autoimmune diabetes in mice. Transpl. Proc., 28, 3072, 1996
    • (1996) Transpl. Proc. , vol.28 , pp. 3072
    • Stosic-Grujicic, S.1    Dimitrijevic, M.2    Bartlett, R.R.3
  • 26
    • 0017089123 scopus 로고
    • Cardiac myosin from pig heart ventricle purification and enzymatic properties
    • Murakami U , Uchida K., Hiratsuka T Cardiac myosin from pig heart ventricle purification and enzymatic properties J Biochem., 80, 611, 1976
    • (1976) J Biochem. , vol.80 , pp. 611
    • Murakami, U.1    Uchida, K.2    Hiratsuka, T.3
  • 27
    • 0028913085 scopus 로고
    • Effects of 15-deoxysperqualin on experimental autoimmune giant cell myocarditis of the rat
    • Kodama M , Zhang S , Hanawa H . et al Effects of 15-deoxysperqualin on experimental autoimmune giant cell myocarditis of the rat. Circulation. 91 1116, 1995
    • (1995) Circulation , vol.91 , pp. 1116
    • Kodama, M.1    Zhang, S.2    Hanawa, H..3
  • 28
    • 0022569618 scopus 로고
    • Variations in the susceptibility of coxackievirus B3-induced myocarditis among different strains of mice
    • Wolfgram L J , Beisel K W Herskowitz A , Rose N R Variations in the susceptibility of coxackievirus B3-induced myocarditis among different strains of mice. J. Immunol, 136, 1846, 1986.
    • (1986) J. Immunol , vol.136 , pp. 1846
    • Wolfgram, L.J.1    Beisel, K.W.2    Herskowitz, A.3    Rose, N.R.4
  • 29
    • 0021018524 scopus 로고
    • Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis
    • Mickey W.F., Gonatas N.K., Kimura H., Wilson D B Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis. J. Immunol., 131, 2805, 1983
    • (1983) J. Immunol. , vol.131 , pp. 2805
    • Mickey, W.F.1    Gonatas, N.K.2    Kimura, H.3    Wilson, D.B.4
  • 30
    • 0018152065 scopus 로고
    • Alkaline phosphatase and peroxidase for double immunoenzymatic labeling of cellular constituents
    • Mason D Y, Damon M.E. Alkaline phosphatase and peroxidase for double immunoenzymatic labeling of cellular constituents. J. Clin. Pathol., 31, 454 1978.
    • (1978) J. Clin. Pathol. , vol.31 , pp. 454
    • Mason, D.Y.1    Damon, M.E.2
  • 31
    • 0025098726 scopus 로고
    • Immunohistochemical characterization of rat thymic non-lymphoid cells. II Macrophages and granulocytes defined by monoclonal antibodies
    • Colic M., Popovic Lj., Gasic S . et al. Immunohistochemical characterization of rat thymic non-lymphoid cells. II Macrophages and granulocytes defined by monoclonal antibodies. Immunology, 69, 416, 1990.
    • (1990) Immunology , vol.69 , pp. 416
    • Colic, M.1    Popovic, Lj.2    Gasic, S.3
  • 34
    • 0028031173 scopus 로고
    • Differential effects of leflunomide on leukocytes: Inhibition of rat in vivo adhesion and in vitro oxidative burst without affecting surface marker modulation
    • Ztelinski T., Muller H J , Schleyerbach R., Bartlett R R. Differential effects of leflunomide on leukocytes: inhibition of rat in vivo adhesion and in vitro oxidative burst without affecting surface marker modulation Agents Actions, 41, C276, 1994.
    • (1994) Agents Actions , vol.41
    • Ztelinski, T.1    Muller, H.J.2    Schleyerbach, R.3    Bartlett, R.R.4
  • 35
    • 0027501428 scopus 로고
    • Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
    • Mattar T., Kochhar K., Bartlett R.R., Bremer E.G., Finnegan A Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett., 334, 161. 1993.
    • (1993) FEBS Lett. , vol.334 , pp. 161
    • Mattar, T.1    Kochhar, K.2    Bartlett, R.R.3    Bremer, E.G.4    Finnegan, A.5
  • 38
    • 0029127555 scopus 로고
    • Dihydroorotats dehydrogenase is a high affinity binding protein for A 771726 and mediator of a range of biological effects of the immunomodulatory compound
    • Williamson R A , Yea C.M , Robson P.A , et al. Dihydroorotats dehydrogenase is a high affinity binding protein for A 771726 and mediator of a range of biological effects of the immunomodulatory compound J. Biol Chem., 270. 22467, 1995.
    • (1995) J. Biol Chem. , vol.270 , pp. 22467
    • Williamson, R.A.1    Yea, C.M.2    Robson, P.A.3
  • 39
    • 0029904990 scopus 로고    scopus 로고
    • Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis
    • Dimitrijevic M., Bartlett R R. Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis. Inflamm Res . 45, 556, 1996.
    • (1996) Inflamm Res . , vol.45 , pp. 556
    • Dimitrijevic, M.1    Bartlett, R.R.2
  • 40
    • 0028792355 scopus 로고
    • Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis Results of a randomized, placebocontrolled phase II study
    • Mladenovic V, Domljan Z , Rozman B , et al Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis Results of a randomized, placebocontrolled phase II study Arthr Rheum., 38, 1595, 1995
    • (1995) Arthr Rheum. , vol.38 , pp. 1595
    • Mladenovic, V.1    Domljan, Z.2    Rozman, B.3
  • 41
    • 0029092719 scopus 로고
    • A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells
    • Suzuki K A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells. Virchows Arch., 426, 493, 1995.
    • (1995) Virchows Arch. , vol.426 , pp. 493
    • Suzuki, K.1
  • 42
    • 0030475056 scopus 로고    scopus 로고
    • Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
    • Thomas R., Lipsky P.E. Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis? Immunol. Today, 17, 559, 1996
    • (1996) Immunol. Today , vol.17 , pp. 559
    • Thomas, R.1    Lipsky, P.E.2
  • 44
    • 0025337235 scopus 로고
    • Characterization of the tissue macrophage and the interstitial dendritic cells as distinct leukocytes normally resident in the connective tissue of rat heart
    • Spencer S.C., Fabre J W. Characterization of the tissue macrophage and the interstitial dendritic cells as distinct leukocytes normally resident in the connective tissue of rat heart J. Exp Med , 171, 1841, 1990.
    • (1990) J. Exp Med , vol.171 , pp. 1841
    • Spencer, S.C.1    Fabre, J.W.2
  • 45
    • 0031045622 scopus 로고    scopus 로고
    • Origin. maturation and antigen presenting function of dendritic cells
    • Cella M , Sallusto F., Lanzavecchia A Origin. maturation and antigen presenting function of dendritic cells. Curr. Opin Immunol., 9, 10, 1997
    • (1997) Curr. Opin Immunol. , vol.9 , pp. 10
    • Cella, M.1    Sallusto, F.2    Lanzavecchia, A.3
  • 46
    • 0025999837 scopus 로고
    • Myosin-induced acuse myocarditis is a T-cell mediated disease
    • Smith S.C., Allen P.M. Myosin-induced acuse myocarditis is a T-cell mediated disease. J. Immunol , 147, 2141, 1991
    • (1991) J. Immunol , vol.147 , pp. 2141
    • Smith, S.C.1    Allen, P.M.2
  • 47
    • 0026585857 scopus 로고
    • In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis
    • Kodama M., Matsumoto Y, Fujiwara M In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis. Circulation 85, 1918, 1992.
    • (1992) Circulation , vol.85 , pp. 1918
    • Kodama, M.1    Matsumoto, Y.2    Fujiwara, M.3
  • 48
    • 0028175986 scopus 로고
    • Anti-αβ T-cell receptor antibody prevents the progression of experimental autoimmune myocarditis
    • Hanawa H , Kodama M., Inornate T., et al Anti-αβ T-cell receptor antibody prevents the progression of experimental autoimmune myocarditis Clin. Exp. Immunol., 96, 470, 1994.
    • (1994) Clin. Exp. Immunol. , vol.96 , pp. 470
    • Hanawa, H.1    Kodama, M.2    Inornate, T.3
  • 49
    • 0025610373 scopus 로고
    • Cardiac myosin-induced myocarditis: Heart autoantibodies are not involved in the induction of the disease
    • Neu N , Ploier B , Ofner C Cardiac myosin-induced myocarditis: heart autoantibodies are not involved in the induction of the disease J. Immunol , 145, 4094, 1990.
    • (1990) J. Immunol , vol.145 , pp. 4094
    • Neu, N.1    Ploier, B.2    Ofner, C.3
  • 50
    • 0028308264 scopus 로고
    • Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides
    • Wegmann K.W , Zhao W , Griffin A.C., Hickey W F Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides. J. Immunol., 153, 892, 1994
    • (1994) J. Immunol. , vol.153 , pp. 892
    • Wegmann, K.W.1    Zhao, W.2    Griffin, A.C.3    Hickey, W.F.4
  • 51
    • 0025953403 scopus 로고
    • Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes
    • Oppenheimer-Marks N , Davis L S., Brogue D.T., Ramberg J , Lipsky P.E. Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes. J. Immunol., 147, 2913, 1991
    • (1991) J. Immunol. , vol.147 , pp. 2913
    • Oppenheimer-Marks, N.1    Davis, L.S.2    Brogue, D.T.3    Ramberg, J.4    Lipsky, P.E.5
  • 52
    • 0004576919 scopus 로고
    • The role of cell adhesion in the evolution of inflammatory arthritis
    • Wegner C.D. (Ed.) Academic Press, London
    • Oppenheimer-Marks N., Lipsky P E. The role of cell adhesion in the evolution of inflammatory arthritis. In Wegner C.D. (Ed.) "Adhesive Molecules" Academic Press, London, 1994, pp. 141-161.
    • (1994) Adhesive Molecules , pp. 141-161
    • Oppenheimer-Marks, N.1    Lipsky, P.E.2
  • 53
    • 0026770377 scopus 로고
    • Integrins. versality, modulation and signaling in cell adhesion
    • Hynes R O Integrins. versality, modulation and signaling in cell adhesion. Cell, 69, 11, 1992.
    • (1992) Cell , vol.69 , pp. 11
    • Hynes, R.O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.