Solid-state rehydration-induced recovery of bilirubin oxidase activity in lyophilized formulations reduced during freeze-drying

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 6, 1998, Pages 1031-1033

  Nakai, Yuji ^a   Yoshioka, Sumie ^a   Aso, Yukio ^a   Kojima, Shigeo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Activity recovery; Bilirubin oxidase; Freeze drying; Rehydration

Indexed keywords

BILIRUBIN; DEXTRAN; OXIDOREDUCTASE; POLYVINYL ALCOHOL;

ARTICLE; DEHYDRATION; DRUG FORMULATION; ENZYME ACTIVITY; FREEZE DRYING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE; REHYDRATION;

EID: 0031950419     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1031     Document Type: Article

References (2)

1. Costantino H. R., Griebenovv K., Mishra P., Langer R., Klibanov A., Biochim. Biophys. Acta, 1253, 69-74 (1995).
2. Costantino H., Nguyen T., Hsu C. C., Pharm. Sci., 2, 229-232 (1996).