Interferon-α: Evolving therapy for AIDS-associated Kaposi's sarcoma

Journal of Interferon and Cytokine Research

Volumn 18, Issue 4, 1998, Pages 209-214

  Krown, Susan E ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; LYMPHOBLAST INTERFERON; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTINEOPLASTIC ACTIVITY; CANCER SURVIVAL; CLINICAL TRIAL; HUMAN; KAPOSI SARCOMA; PRIORITY JOURNAL; REVIEW; VIRUS INHIBITION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0031949978     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.209     Document Type: Review

References (68)

1. CENTERS FOR DISEASE CONTROL. (1981). Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men - New York City and California. MMWR 30, 305.
2. GOTTLIEB, M.S., SCHROFF, R., SCHANKER, H.M., WEISMAN, J.D., FAIN, P.T., WOLF, R.A., and SAXON, A. (1981). Pneumocystic carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl. J. Med. 305, 1425-1431.
3. MASUR, H., MICHELIS, M.A., GREENE, J.B., ONORATO, I., STOUWE, R.A., HOLZMAN, R.S., WORMSER, G., BRETTMAN, L., LANGE, M., MURRAY, H.W., and CUNNINGHAM-RUNDLES, S. (1981). An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med. 305, 1431-1438.
4. SIEGAL, F.P., LOPEZ, C., HAMMER, G.S., BROWN, A.E., KORNFELD, S.J., GOLD, J., HASSETT, J., HIRSCHMAN, S.Z., CUNNINGHAM-RUNDLES, C., ADELSBERG, B.R., et al. (1981). Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal herpes simplex lesions. N. Engl. J. Med. 305, 1439-1444.
5. DURACK, D.T. (1981). Opportunistic infections and Kaposi's sarcoma in homosexual men [Editorial]. N. Engl. J. Med. 305, 1465-1467.
6. GIRALDO, G., BETH, E., and HAGUENAU, F. (1972). Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions. J. Natl. Cancer Inst. 49, 1509-1526.
7. GIRALDO, G., BETH, E., KOURILSKY, F.M., HENLE, W., HENLE, G., MIKÉ, V., HURAUX, J.M., ANDERSEN, H.K., GHARBI, M.R., KYALWAZI, S.K., and PUISSANT, A. (1975). Antibody patterns to herpes viruses in Kaposi's sarcoma: serological association of European Kaposi's sarcoma with cytomegalovirus. Int. J. Cancer 15, 839-848.
8. HARWOOD, A.R., OSOBA, D., HOFSTADER, S.L., GOLDSTEIN, M., CARDELLA, C., HOLECEK, M., KUNYNETZ, R., and GIAMMARCO, R.A. (1979). Kaposi's sarcoma in recipients of renal transplants. Am. J. Med. 67, 759-765.
9. MYERS, B.D., KESSLER, E., LEPI, J., PICK, A., ROSENFELD, J.B., and TIKVAH, P. (1974). Kaposi's sarcoma in kidney transplant recipients. Arch. Intern. Med. 133, 307-311.
10. KROWN, S.E., REAL, F.X., CUNNINGHAM-RUNDLES, S., MYSKOWSKI, P.L., KOZINER, B., FEIN, S., MITTLEMAN, A., OETTGEN, H.F., and SAFAI, B. (1983). Preliminary observations on the effect of recombinant leukocyte A interferon in homosexual men with Kaposi's sarcoma. N. Engl. J. Med. 308, 1071-1076.
11. KROWN, S.E., REAL, F.X., KRIM, M., CUNNINGHAM-RUNDLES, S., KOZINER, B., MYSKOWSKI, P.L., SAFAI, B., and OETTGEN, H.F. (1984). Recombinant leukocyte A interferon in Kaposi's sarcoma. Ann. NY Acad. Sci. 437, 431-437.
12. DESTEFANO, E., FRIEDMAN, R.M., FRIEDMAN-KIEN, A.E., GOEDERT, J.J., HENRIKSEN, D., PREBLE, O.T., SONNABEND, J.A., and VILCEK, J. (1982). Acid-labile human leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy. J. Infect. Dis. 146, 451-455.
13. VILCEK, J. (1984). Adverse effects of interferon in virus infections, autoimmune diseases and acquired immunodeficiency. Prog. Med. Virol. 30, 62-77.
14. GROOPMAN, J.E., GOTTLIEB, M.S., GOODMAN, J., MITSUYASU, R.T., CONANT, M.A., PRINCE, H., FAHEY, J.L., DEREZIN, M., WEINSTEIN, W.M., CASAVANTE, C., et al. (1984). Recombinant alpha-2 interferon therapy for Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. Ann. Intern. Med. 100, 671-676.
15. GELMANN, E.P., PREBLE, O.T., STEIS, R., LANE, H.C., ROOK, A.H., WESLEY, M., JACOB, J., FAUCI, A., MASUR, H., and LONGO, D. (1985). Human lymphoblastoid interferon treatment of Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical response and prognostic parameters. Am. J. Med. 78, 737-741.
16. RIOS, A., MANSELL, P.W.A., NEWELL, G.R., REUBEN, J.M., HERSH, E.M., and GUTTERMAN, J.U. (1985). Treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma with lymphoblastoid interferon. J. Clin. Oncol. 3, 506-512.
17. LOPEZ, C., FITZGERALD, P.A., and SIEGAL, F.P. (1983). Severe acquired immune deficiency syndrome in male homosexuals: diminished capacity to make interferon-alpha in vitro associated with severe opportunistic infections. J. Infect. Dis. 148, 962-966.
18. MURRAY, H.W., RUBIN, B.Y., MASUR, H., and ROBERTS, R.B. (1984). Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome. N. Engl. J. Med. 310, 883-889.
19. REAL, F.X., OETTGEN, H.F., and KROWN, S.E. (1986). Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon. J. Clin. Oncol. 4, 544-551.
20. BARRE-SINOUSSI, F., CHERMANN, J.C., REY, F., NUGEYRE, M.T., CHAMARET, S., GRUEST, J., DAUGUET, C., AXLERBLIN, C., VEZINET-BRUN, F., ROUZIOUX, C, ROZENBAUM, W., and MONTAGNIER, L. (1983). Isolation of a T-lymphotropic virus from patients at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871.
21. HO, D.D., HARTSHORN, K.L., ROTA, T.R., ANDREWS, C.A., KAPLAN, J.C., SCHOOLEY, R.T., and HIRSCH, M.S. (1985). Recombinant human interferon alpha-A suppresses HTLV-III replication in vitro. Lancet 1, 602-604.
22. EVANS, L.M., ITRI, L.M., CAMPION, M., WYLER-PLAUT, R., KROWN, S.E., GROOPMAN, J.E., GOLDSWEIG, H., VOLBERDING, P.A., WEST, S.B., MITSUYASU, R.T., and DZIEWANOWSKA, Z.E. (1991). Interferon alfa-2a in the treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma. J. Immunother. 10, 39-50.
23. KRIGEL, R.L., SLYWOTZKY, C.M., LONBERG, M., GREEN, M.D., ANDES, W.A., KEMPF, R., GUPTA, S., GRACE, W., SPIEGEL, R.J., MUGGIA, F.M., et al. (1988). Treatment of epidemic Kaposi's sarcoma with a combination of interferon-α2b and etoposide. J. Biol. Response Mod. 7, 359-364.
24. SHEPHERD, F.A., EVANS, W.K., GARVEY, B., READ, S.E., KLEIN, M., FANNING, M.M., and COATES, R. (1988). Combination chemotherapy and α-interferon in the treatment of Kaposi's sarcoma associated with acquired immune deficiency syndrome. Can. Med. Assoc. J. 139, 635-639.
25. VADHAN-RAJ, S., WONG, G., GNECCO, C., CUNNINGHAM-RUNDLES, S., KRIM, M., REAL, F.X., OETTGEN, H.F., and KROWN, S.E. (1986). Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome. Cancer Res. 46, 417-425.
26. LAU, A.S., READ, S.E., and WILLIAMS, B.R. (1988). Down-regulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome. J. Clin. Invest. 32, 1415-1421.
27. PREBLE, O.T., ROOK, A.H., STEIS, R., SILVERMAN, R.H., KRAUSE, D., QUINNAN, G.V., MASUR, H., JACOB, J., LONGO, D., and GELMANN, E.P. (1985). Interferon-induced 2′-5′ oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome. J. Infect. Dis. 152, 457-465.
28. LANE, H.C., DAVEY, V., KOVACS, J.A., FEINBERG, J., METCALF, J.A., HERPIN, B., WALKER, R., DEYTON, L., DAVEY, R.T. Jr., FALLOON, J., POLIS, M.A., SALZMAN, N.P., BASELER, M., MASUR, H., and FAUCI, A.S. (1990). Interferon-alpha in patients with asymptomatic human immunodeficiency virus (HIV) infection: a randomized, placebo-controlled trial. Ann. Intern. Med. 112, 805-811.
29. LANE, H.C., KOVACS, J.A., FEINBERG, J., HERPIN, B., DAVEY, V., WALKER, R., DEYTON, L., METCALF, J.A., BASELER, M., SALZMAN, N., MANISCHEWITZ, J., QUINNAN, G., MASUR, H., and FAUCI, A.S. (1988). Anti-retroviral effects of interferon-alpha in AIDS-associated Kaposi's sarcoma. Lancet 2, 1218-1222.
30. DEWIT, R., SCHATENKERK, J.K.M.E., BOUCHER, C.A.B., BAKKER, P.J., VEENHOF, K.H., and DAMNER, S.A. (1988). Clinical and virological effects of high-dose recombinant interferon-α in disseminated AIDS-related Kaposi's sarcoma. Lancet 2, 1214-1217.
31. HARTSHORN, K.L., VOGT, M.W., CHOU, T.-C., BLUMBERG, R.S., BYINGTON, R., SCHOOLEY, R.T., and HIRSCH, M.S. (1987). Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant interferon alpha A. Antimicrob. Agents Chemother. 31, 168-172.
32. VOGT, M.W., DURNO, A.G., CHOU, T.C., COLEMAN, L.A., PARADIS, T.J., SCHOOLEY, R.T., KAPLAN, J.C., and HIRSCH, M.S. (1988). Synergistic interaction of 2′,3′-dideoxycytidine (dd-Cyd) and recombinant interferon alpha A (rIFN-αA) on HIV-1 replication. J. Infect. Dis. 158, 378-385.
33. JOHNSON, V.A., BARLOW, M.A., MERRILL, D.P., CHOU, T.-C., and HIRSCH, M.S. (1990). Three-drug synergistic inhibition of HIV-1 replication in vitro by zidovudine, recombinant soluble CD4, and recombinant interferon-alpha A. J. Infect. Dis. 161, 1059-1067.
34. RUPRECHT, R.M., CHOU, T., CHIPTY, F., SOSA, M.G., MULLANEY, S., O'BRIEN, L., and ROSAS, D. (1990). Interferon-α and 3′-azido-3′-deoxy thymidine are highly synergistic in mice and prevent viremia after acute retrovirus exposure. J. Acquir. Immune Defic. Syndr. 3, 591-600.
35. KOVACS, J.A., DEYTON, L., DAVEY, R., FALLOON, J., ZUNICH, K., LEE, D., METCALF, J.A., BIGLEY, J., SAWYER, L.A., ZOON, K.C., MUSUR, H., FAUCI, A.S., and LANE, H.C. (1989). Combined zidovudine and interferon-α therapy in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 111, 280-287.
36. FISCHL, M.A., UTTAMCHANDANI, R., RESNICK, L., AGARWAL, R., FLETCHER, M.A., PATRONE-REESE, J., DEARMAS, L., CHIDEKEL, J., McCANN, M., and MYERS, M. (1991). A phase I study of recombinant human interferon alfa-2a or human lymphoblastoid interferon alfa-n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. J. Acquir. Immune Defic. Syndr. 4, 1-10.
37. KROWN, S.E., GOLD, J.W.M., NIEDZWIECKI, D., BUNDOW, D., FLOMENBERG, N., GANSBACHER, B., and BREW, B.J. (1990). Interferon-α with zidovudine: safety, tolerance, and clinical and virologie effects in patients with Kaposi's sarcoma associated with the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 112, 812-821.
38. SIDKY, Y.A., and BORDEN, E.C. (1987). Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res. 47, 5155-5161.
39. MILDVAN, D., BASSIAKOS, Y., ZUCKER, M.L., HYSLOP, N. Jr., KROWN, S.E., SACKS, H.S., ZACHARY, J., PAREDES, J., FESSEL, W.J., RHAME, F., KRAMER, F., FISCHL, M.A., POIESZ, B., WOOD, K., RUPRECHT, R.M., KIM, J., GROSSBERG, S.E., KASDAN, K., BERGE, P., MARSHAK, A., and PETTINELLI, C. (1996). Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: ACTG 068. Antiviral Ther. 1, 77-88.
40. CHOU, T.-C., and TALALAY, P. (1984). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22, 27-55.
41. 2-microglobulin and neopterin serum levels in patients with Kaposi sarcoma and acquired immunodeficiency syndrome (AIDS). J. Acquir. Immune Defic. Syndr. 4, 871-880.
42. MILDVAN, D., MACHADO, S.G., WILETS, I., and GROSSBERG, S.E. (1992). Endogenous interferon and triglyceride concentrations to assess response to zidovudine in AIDs and advanced AIDS-related complex. Lancet 339, 453-156.
43. JACOBSON, M.A., ABRAMS, D.I., VOLBERDING, P.A., BACCHETTI, P., WILBER, J., CHAISSON, R.E., CROWE, S., HOWARD, W., and MOSS, A. (1989). Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. J. Infect. Dis. 159, 1029-1036.
44. SCADDEN, D.T., BERING, H.A., LEVINE, J.D., BRESNAHAN, J., EVANS, L., EPSTEIN, C., and GROOPMAN, J.E. (1991). Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma. J. Clin. Oncol. 9, 802-808.
45. KROWN, S.E., PAREDES, J., BUNDOW, D., POLSKY, B., GOLD, J.W.M., and FLOMENBERG, N. (1992). Interferon-α, zidovudine and granulocyte-macrophage colony-stimulating factor: a phase I trial in patients with Kaposi's sarcoma associated with the acquired immunodeficiency syndrome (AIDS). J. Clin. Oncol. 10, 1344-1351.
46. KITANO, K., BALDWIN, G.C., RAINES, M.A., and GOLDE, D.W. (1991). Differentiating agents facilitate infection of myeloid leukemia cell lines by monocytotropic HIV-1 strains. Blood 76, 1980-1988.
47. AMMANN, A.J., PALLADINO, M.A., VOLBERDING, P., ABRAMS, D., MARTIN, N.L., and CONANT, M. (1987). Tumor necrosis factors alpha and beta in acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J. Clin. Immunol. 7, 481-485.
48. BIRX, D.L., REDFIELD, R.R., TENCER, K., FOWLER, A., BURKE, D.S., and TOSATO, G. (1990). Induction of interleukin-6 during human immunodeficiency virus infection. Blood 76, 2303-2310.
49. BREEN, E.C., REZAI, A.R., NAKAJIMA, K., BEALL, G.N., MITSUYASU, R.T., HIRANO, T., KISHIMOTO, T., and MARTINEZ-MAZA, O. (1990). Infection with HIV is associated with elevated IL-6 levels and production. J. Immunol. 144, 480-484.
50. MOLINA, J.-M., SCADDEN, D.T., BYRN, R., DINARELLO, C.A., and GROOPMAN, J.E. (1989). Production of tumor necrosis factor a and interleukin 1β by monocytic cells infected with human immunodeficiency virus. J. Clin. Invest. 84, 733-737.
51. POLI, G., BRESSLER, P., KINTER, A., DUH, E., TIMMER, W.C., RABSON, A., JUSTEMENT, J.S., STANLEY, S., and FAUCI, A.S. (1990). Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor a by transcriptional and posttranscriptional mechanisms. J. Exp. Med. 172, 151-158.
52. SALAHUDDIN, S.Z., NAKAMURA, S., BIBERFELD, P., KAPLAN, M.H., MARKHAM, P.D., LARSSON, L., and GALLO, R.C. (1988). Angiogenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science 242, 430-433.
53. ENSOLI, B., NAKAMURA, S., SALAHUDDIN, S.Z., BIBERFELD, P., LARSSON, L., BEAVER, B., WONG-STAAL, F., and GALLO, R.C. (1989). AIDS Kaposi's sarcoma derived cells express cytokines with autocrine and paracrine growth effects. Science 243, 223-226.
54. MILES, S.A., REZAI, A.R., SALAZAR-GONZALEZ, J.F., VANDER MEYDEN, M., STEVENS, R.H., LOGAN, D.M., MITSUYASU, R.T., TAGA, T., HIRANO, T., KISHIMOTO, T., et al. (1990). AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc. Natl. Acad. Sci. USA 87, 4068-1072.
55. BARILLARI, G., BUONAGURO, L.L., FIORELLI, V., HOFFMAN, J., MICHAELS, F., GALLO, R.C., and ENSOLI, B. (1992). Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression: implications for AIDS-Kaposi's sarcoma pathogenesis. J. Immunol. 149, 3727-3734.
56. BARILLARI, G., GENDELMAN, R., GALLO, R.C., and ENSOLI, B. (1993). The Tat protein of human immunodeficiency virus type I, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc. Natl. Acad. Sci. USA 90, 7941-7945.
57. MILES, S.A., MARTINEZ-MAZA, O., REZAI, A., MAGPANTAY, L., KISHIMOTO, T., NAKAMURA, S., RADKA, S.F., and LINSLEY, P.S. (1992). Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255, 1432-1434.
58. NAIR, B.C., DEVICO, A.L., NAKAMURA, S., COPELAND, T.D., CHEN, Y., PATEL, A., O'NEIL, T., OROSZLAN, S., GALLO, R.C., and SARNGADHARAN, M.G. (1992). Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. Science 255, 1430-1432.
59. ENSOLI, B., BARILLARI, G., SALAHUDDIN, S.Z., GALLO, R.C., and WONG-STAAL, F. (1990). Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 345, 84-86.
60. ENSOLI, B., BUONAGURO, L., BARILLARI, G., FIORELLI, V., GENDELMAN, R., MORGAN, R.A., WINGFIELD, P., and GALLO, R.C. (1993). Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J. Virol. 67, 277-287.
61. ENSOLI, B., GENDELMAN, R., MARKHAM, P., FIORELLI, V., COLOMBINI, S., RAFFELD, M., CAFARO, A., CHANG, H.K., BRADY, J.N., and GALLO, R.C. (1994). Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature 371, 674-680.
62. TILG, H., MIER, J.M., VOTEL, W., AULITZKY, W.E., WIEDERMANN, C.J., VANNIER, E., HUBER, C., and DINARELLO, C.A. (1993). Induction of circulating IL-1 receptor antagonist by IFN treatment. J. Immunol. 150, 4687-4692.
63. TILG, H., VOGEL, W., and DINARELLO, C.A. (1995). Interferon-α induces circulating tumor necrosis factor receptor in humans. Blood 85, 433-435.
64. SINGH, R.K., GUTMAN, M., BUCANA, C.D., SANCHEZ, R., LLANSA, N., and FIDLER, I.J. (1995). Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc. Natl. Acad. Sci. USA 92, 4562-4566.
65. CHANG, Y., CESARMAN, E., PESSIN, M.S., LEE, F., CULPEPPER, J., KNOWLES, D.M., and MOORE, P.S. (1994). Identification of herpes virus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869.
66. MOORE, P.S., and CHANG, Y. (1995). Detection of herpes virus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N. Engl. J. Med. 332, 1181-1185.
67. BARAHONA, H.H., and MELENDEZ, L.V. (1971). Herpesvirus saimir in vitro sensitivity to virus-induced interferon and to polyriboinosinic polyribocytidylic acid. Proc. Soc. Exp. Biol. Med. 136, 1163-1166.
68. REITER, Z., OZES, O.N., BLATT, L.M., STURZL, M., and TAYLOR, M.W. (1992). A possible role for interferon-alpha and activated natural killer cells in remission of AIDS-related Kaposi's sarcoma: in vitro studies. J. Acquir. Immune Defic. Syndr. 5, 469-476.