Distributional pattern of apoptotic cells in rat cerebellar vermis experimentally induced by methylmercury intoxication

Neuropathology

Volumn 18, Issue 1, 1998, Pages 33-37

  Kobayashi, Yoshiyasu ^a   Sawa, Hirofumi ^a   Akagi, Hirokatsu ^b   Itakura, Chitoshi ^c   Fujioka, Yasunori ^a   Nagashima, Kazuo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^c INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Apoptosis; Cerebellum; Distribution; Methylmercury chloride; Toxicosis; TUNEL

Indexed keywords

METHYLMERCURY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CEREBELLUM DEGENERATION; CEREBELLUM VERMIS; CONTROLLED STUDY; DYING; GRANULE CELL; HINDLIMB; INTOXICATION; MINAMATA DISEASE; NONHUMAN; PARALYSIS; PATHOLOGY; PRIORITY JOURNAL; RAT;

EID: 0031949578     PISSN: 09196544     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1789.1998.tb00075.x     Document Type: Article

References (7)

1. Hunter D, Russell DS. Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds. J Neurol Neurosurg Psych 1954; 17: 235-241.
2. Takeuchi T, Morikawa N, Matsumoto H, Shiraishi Y. A pathological study of Minamata disease in Japan. Acta Neuropathol (Berl) 1962; 2: 40-57.
3. Fukuhara N. Ultrastructural changes in the cerebellar granule cell layers of experimental organic mercury poisoning in rats (in Japanese with English abstract). Rinsho Shinkeigaku 1969; 9: 187-198.
4. Miyakawa T, Deshimaru M. Electron microscopical study of experimentally induced poisoning due to organic mecury compound. Mechanisms of development of the morbid change. Acta Neuropathol (Berl) 1969; 14: 126-136.
5. Leyshon K, Morgan AJ. An integrated study of the morphological and gross-elemental consequences of methylmercury intoxication in rats, with particular attention on cerebellum. Scanning Microsc 1991; 5: 895-904.
6. Nagshima K, Fujii Y, Tsukamoto T et al. Apoptotic process of cerebellar degeneration in experimental methylmercury intoxication of rats. Acta Neuropathol (Berl) 1996; 91: 72-77.
7. Oyanagi K, Ohama E, Ikuta F, Igarashi S, Nakano Y. The vestibular system and cerebellum in organic mercury intoxication; an otolaryngological and neuropathological investigation on 14 autopsy cases in Niigata (in Japanese with English abstract). Nou to Shinkei 1989; 41: 711-717.