Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins

Journal of Pharmaceutical Sciences

Volumn 87, Issue 4, 1998, Pages 496-500

  Richter, Wolfgang F ^a   Heizmann, Peter ^a   Meyer, Joseph ^a   Starke, Volkmar ^a   Lave, Thierry ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; RO 256833; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBIOTIC THERAPY; ARTICLE; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONKEY; NONHUMAN; RAT; SPECIES DIFFERENCE; URINARY EXCRETION;

EID: 0031949326     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js970261f     Document Type: Article

References (14)

1. Heinze-Krauss, I.; Angehrn, P.; Guerry, P.; Hebeisen, P.; Hubschwerlen, C.; Kompis, L; Page, M. G. P.; Richter, H. G. F.; Runtz, V.; Stalder, H.; Weiss, U.; Wie, C.-C. Synthesis and structure - activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneunococci, and enterococci. J. Med. Chem. 1996, 39, 1864-1871.
2. Sawada, Y.; Hanano, M.; Sugiyama, Y.; Iga, T. Prediction of the disposition of β-lactam antibiotics in humans from pharmacokinetic parameters in animals. J. Pharmacokinet. Biopharm. 1984, 241-261.
3. Mordenti, J. Forecasting cephalosporin and monobactam antibiotic half-lives in humans from data collected in laboratory animals. Antimicrob. Agents Chemother, 1985, 27, 887-891.
4. Matsushita, H.; Suzuki, H.; Sugiyama, Y.; Sawada, Y.; Iga, T.; Hanano, M.; Kawaguchi, Y. Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals. J. Pharmacobio-Dyn. 1990, 13, 602-611.
5. Mordenti, J. Pharmacokinetic scale-up: Accurate prediction of human pharmacokinetic profiles from animal data. J. Pharm. Sci. 1985, 74, 1097-1099.
6. Boxenbaum, H.; Ronfeld, R. Interspecies pharmacokinetic scaling and the Dedrick plot. Am. J. Physiol. 1983, 245, R768-774.
7. Efthymiopoulos, C.; Battaglia, R.; Strolin Benedetti, M. Animal pharmacokinetics and interspecies scaling of FCE 22101, a penem antibiotic. J. Antimicrob. Chemother. 1991, 27, 517-526.
8. Boxenbaum, B.; D'Souza, R. W. Interspecies pharmacokinetic scaling, biological design and nepteny. In Advances in Drug Research; Testa, B., Ed.; Academic Press Ltd.: London, 1990; 139-196.
9. Oie, S.; Tozer, T. N. Effect of altered plasma protein binding on apparent volume of distribution. J. Pharm. Sci. 1979, 68, 1203-1205.
10. Loeb, W. F.; Quimby, F. W. The Clinical Chemistry of Laboratory Animals; Pergamon Press: New York, 1989.
11. Mordenti, J. Man versus beast: Pharmacokinetic scaling in mammals. J. Pharm. Sci. 1986, 75, 1028-1040.
12. Weidekamm, E.; Schweizer, J.; McClelland, G.; Joubert, P.; Heizmann, P. Pharmacokinetics of the new cephalosporin Ro 25-6833 in humans. In Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1995; p 122.
13. Rowland, M.; Tozer, T. Clinical Pharmacokinetics: Concepts and Applications; Lea and Febiger: Philadelphia, London, 1995.
14. Lave, T.; Coassolo, P.; Ubeaud, G.; Brandt, R.; Schmitt, C.; Dupin, S.; Jaeck, D.; Chou, R. C. Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling. Pharm Res. 1996, 13, 97-101.