KA 672-HCl, a neuronal activator against dementia: Tolerability, safety, and preliminary pharmacokinetics after single and multiple oral doses in healthy male and female volunteers

Journal of Clinical Pharmacology

Volumn 38, Issue 4, 1998, Pages 373-381

  Sourgens, Hildegard ^d   Hoerr, Robert ^a   Biber, Anton ^a   Steinbrede, Heike ^b   Derendorf, Hartmut ^c  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^b Focus Clinical Drug Development GmbH   (Germany)

^c UNIVERSITY OF FLORIDA   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

7 METHOXY 6 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPOXY] 3,4 DIMETHYL 2H 1 BENZOPYRAN 2 ONE; BENZOPYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; ORTHOSTATIC HYPOTENSION; RANDOMIZED CONTROLLED TRIAL;

EID: 0031948853     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04438.x     Document Type: Article

References (7)

1. Noeldner M, Hauer H, Chatterjee SS: Anseculin hydrochloride. Drugs Future 1996;21:779-781.
2. Reinikainen KJ, Soininen H, Riekkinen PJ: Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy. J Neurosci Res 1990;27:576-586.
3. Decker MW, McGaugh JL: The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 1991;7:151-168.
4. Francis PT, Cross AJ, Bowen DM: Neurotransmitters and neuropeptides. In, Terry RD, Katzman R, Bick KL (eds.): Alzheimer Disease. New York: Raven Press, 1994;247-261.
5. 1A receptor modulators. In, Robertson DW (ed.): Annual Reports in Medicinal Chemistry, Section I: Central Nervous System Diseases. Volume 30. San Diego, CA: Academic Press, 1995;1-9.
6. Shah VP, Midha KK, Dighe S, McGilveray IJ, Skelly JP, Yacobi A, et al: Analytical method validation: bioavailability, bioequivalence and pharmacokinetic studies. Eur J Drug Metab Pharmacokinet 1991;16:249-255.
7. Allen GD: MODFIT: a pharmacokinetic computer program. Biopharm Drug Dispos 1990;11:477-498.