N-methylcarbamoyl adducts at the N-terminal valine of globin in workers exposed to N,N-dimethylformamide

Archives of Toxicology

Volumn 72, Issue 5, 1998, Pages 309-313

  Angerer, Jürgen ^a   Göen, Thomas ^a   Krämer, Axel ^a   Käfferlein, Heiko Udo ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

3 Methyl 5 isopropylhydantoin; Biochemical effect monitoring; Haemoglobin adducts; Methylisocyanate; N Dimethylformamide

Indexed keywords

HEMOGLOBIN; METHYL ISOCYANATE; N,N DIMETHYLFORMAMIDE; SOLVENT;

ARTICLE; BLOOD SAMPLING; CAPILLARY GAS CHROMATOGRAPHY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; OCCUPATIONAL MEDICINE; OCCUPATIONAL TOXICOLOGY; PRIORITY JOURNAL; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ACETYLCYSTEINE; CASE-CONTROL STUDIES; CHEMICAL INDUSTRY; CHROMATOGRAPHY, GAS; DIMETHYLFORMAMIDE; GLOBINS; HETEROCYCLIC COMPOUNDS; HUMANS; MALE; OCCUPATIONAL EXPOSURE; SENSITIVITY AND SPECIFICITY; SOLVENTS; VALINE;

EID: 0031948751     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050507     Document Type: Article

References (19)

1. Bader M, Lewalter J, Angerer J (1995) Analysis of N-alkylated amino acids in human hemoglobin: evidence for elevated N-methylvaline levels in smokers. Int Arch Occup Environ Health 76: 237-242
2. Baillie TA, Slatter JG (1991) Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo. Acc Chem Res 24: 264-270
3. Crist RD, Grisolia S, Bettis CJ, Grisolia J (1973) Carbamoylation of proteins following administration to rats of carbamoyl phosphate and cyanate and effects on memory. Eur J Biochem 32: 109-116
4. DFG Deutsche Forschungsgemeinschaft (1997a) Commission for the investigation of health hazards of chemical compounds in the work area. In: Angerer J, Schaller KH (eds) Analysis of hazardous substances in biological material, vol 5. VCH Weinheim, pp 97-108
5. DFG Deutsche Forschungsgemeinschaft (1997b) Commission for the investigation of health hazards of chemical compounds in the work area. In: Angerer J. Schaller KH (eds) Analysis of hazardous substances in biological material, vol 5. VCH Weinheim, pp 181-210
6. Ducatman AM, Conwill DE, Crawl J (1986) Germ-cell tumors of the testicle among aircraft repairman. J Urol 136: 834-836
7. GDCh, BUA-Advisory Committee of the GDCh on existing chemicals of environmental relevance (1991) N,N-Dimethylformamide. BUA Report 84. Hirzel, Stuttgart
8. Kennedy GL Jr (1986) Biological effects of acetamide, formamide and their monomethyl and dimethyl derivatives. CRC Crit Rev Toxicol 17: 129-182
9. Kestell P, Threadgill MD, Gescher A, Gledhill AP, Shaw AJ, Farmer PB (1987) An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides. J Pharmacol Exp Ther 240: 265-270
10. Mráz J, Nohova H (1992) Absorption, metabolism and elimination of N,N-dimethylformamide in humans. Int Arch Occup Environ Health 64: 85-92
11. Mráz J, Turecek F (1987) Identification of N-acetyl-S-(N-methylcarbamoyl)-cysteine, a human metabolite of N,N-dimethylform-amide and N-methylformamide. J Chromatogr B 414: 399-404
12. Pearson PG, Slatter JG, Rashed MS, Han DH, Baillie TA (1991) Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate. Chem Res Toxicol 4: 436-444
13. Ramachandran PK, Gandhe BR, Venkateswaran KS, Kaushik MP, Vijayaraghavan R, Agarwal GS, Gopalan N, Suryanarayana MVS, Shinde SK (1988) Gas chromatographic studies of the carbamoylation of hemoglobin by methylisocyanate in rats and rabbits. J Chromatogr 426: 239-247
14. Slatter JG, Rashed MS, Pearson PG, Han DH, Baillie TA (1991) Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem Res Toxicol 4: 157-161
15. Sriramachari S, Rao GJ, Varma VK, Jadhav RK, Saraf AK, Chandra H (1991) GC-NPD and GC-MS analysis of preserved tissue of Bhopal gas disaster: Evidence of methylcarbamoylation in post-mortem blood. Med Sci Law 31: 289-293
16. Törnquist M, Osterman-Golkar S, Kautiainen A, Näslund M, Callemann C, Ehrenberg L (1988) Methylations in human hemoglobin. Mutat Res 204: 521-529
17. Törnquist M, Magnusson AL, Farmer PB, Tang YS, Jeffrey AM, Wazneh L, Beulink GD, van-der-Waal H, van Sittert NJ (1992) Ring test for low levels of N-2-hydroxyethylvaline in human hemoglobin. Anal Biochem 203: 357-360
18. Venkateswaran KS, Raghuveeran CD, Gopalan N, Agarwal GS, Kaushik MP, Vijayaraghavan R (1992) Monitoring of hemoglobin-methyl isocyanate adduct by high-performance liquid chromatography with diode array detector. Biochem Int 28: 745-750
19. World Health Organization, International Agency for Research on Cancer (1989) IARC Monographs on the evaluation of carcinogenic risk to humans. Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting, vol 47. WHO, Lyon, pp 186-187