The relationship between intrahepatic portal systemic shunts and microsphere induced portal hypertension in the rat liver

Gut

Volumn 42, Issue 2, 1998, Pages 276-282

  Li, X ^a   Benjamin, I S ^a   Alexander, B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hepatic blood flow; Intrahepatic shunts; Portal hypertension; Rat liver

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; LIVER BLOOD FLOW; LUNG BLOOD VESSEL; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN; PORTAL VEIN BLOOD; PRIORITY JOURNAL; RAT; SHUNTING;

EID: 0031947630     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.2.276     Document Type: Article

References (20)

1. Fernandez-Munoz D, Caramelo C, Santos JC, Blanchart A, Hernando L, Lopez-Novoa JM. Systemic and splanchnic haemodynamic disturbances in conscious rats with experimental liver cirrhosis without ascites. Am J Physiol 1985;249:G316 20.
2. Vorobioff J, Bredfeldt JE, Groszmann RJ. Increased blood flow through the portal system in cirrhotic rats, Gastroenterology 1984;87:1120 6.
3. Geraghty JG, Angerson WJ, Carter DC. Portal venous pressure and portal-systemic shunting in experimental portal hypertension. Am J Physiol 1984;257:G52-7.
4. Bosch J, Mastai R, Kravetz D, Navasa M, Rhodes J. Hemodynamic evaluation of the patient with portal hypertension. Semin Liver Dis 1086;6:309 17.
5. Braillon A, Cailmail S, Gaudin C, Lebrec D. Reduced splanchnic vasoconstriction to angiotensin II in conscious rats with biliary cirrhosis. J Hepatol 1993;17:86-90.
6. Groszmann RJ, Glickman M, Blei AT, Storer E, Conn HO. Wedged and free hepatic venous pressure measured with a balloon catheter. Gastroenterology 1997;76:253 8.
7. Hoefs JC, Reynolds TB, Pare P. A new method for the measurement of intrahepatic shunts. J Lab Clin Med 1984; 103:446 61.
8. Myking AO, Halvorsen JF. A method for graded portal vein stenosis in rats: survival related to degree of stenosis. Eur Surg Res 1973;5:454 7.
9. 4 an adequate model of human cirrhosis? Hepatology 1983;3:112 20.
10. Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993;104:1750 4.
11. Lee SS, Girod C, Braillon A, Hadengue A, Lebrec D. Hemodynamic characterisation of chronic bile duct-ligated rats: effect of pentobarbital sodium. Am J Physiol 1986;251: G176-80.
12. Jaffe V, Alexander B, Mathie RT. Intrahepatic portal occlusion by microspheres: a new model of portal hypertension in the rat. Gut 1994;35:815 18.
13. Wood AJJ, Villeneuve JP, Branch RA, Rogers LM, Shand DG. Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat. Gastroenterology 1979;76:1358 62.
14. Okuda K, Suzuki K, Musha H, Arimizu N. Percutaneous transhepatic catheterisation of the portal vein for the study of portal haemodynamics and shunts. Gastroenterology 1977;73:279 84.
15. Huet P-M, Gilles P-L, Villeneuve J-P, Varin F, Viallet A. Intrahepatic circulation in liver disease. Semin Liver Dis 1986;6:277 86.
16. Lin HC, Yu PC, Lee SD, Tsai YT, Kuo JS, Yany MCM. Effects of reserpine administration in two models of portal hypertension in rats. J Hepatol 1993;19:413 7.
17. Lautt WW, Legare DJ. Passive autoregulation of portal venous pressure: distensible hepatic resistance. Am J Physiol 1992;263:G702 8.
18. Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: the hepatic arterial buffer response. Am J Physiol 1985;249:G549 56.
19. Alexander B, Cottam H, Naftalin RJ. Evidence that rat hepatic arterial pressure and altered pre-sinusoidal resistance affect intrahepatic shunt flow in vitro. J Physiol 1996; 495:102.
20. Alexander B, Naftalin RJ, Rogers C. Evidence from in vitro glucose uptake that hepatic arterial perfusion is required to maintain the sinusoids open to portal venous perfusion. J Physiol 1996;495:97.