Serum CRP and IL-6 levels after trauma. Not predictive of septic complications in 31 patients

Acta Orthopaedica Scandinavica

Volumn 69, Issue 2, 1998, Pages 184-188

  Giannoudis, Panagiotis V ^a   Smith, Malcolm R ^a   Evans, Robert T ^a   Bellamy, Mark C ^a   Guillou, Pierre J ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 6;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BLUNT TRAUMA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INJURY SCALE; MALE; POSTOPERATIVE INFECTION; PROTEIN BLOOD LEVEL; REFERENCE VALUE; SEPSIS; TIME;

EID: 0031947306     PISSN: 00016470     EISSN: None     Source Type: Journal    
DOI: 10.3109/17453679809117625     Document Type: Article

References (23)

1. Akira S, Tetsuya T, Tadamitsu K. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54: 1-78.
2. Bank U, Reihold D, Kunz H V et al. Effects of IL-6 and transforming growth factor-ß (TGF-ß) on neutrophil elastase release. Inflammation 1995; 19: 83-9.
3. Bone R C, Fisher C J, Clemmer T P et al. Methylprednisolone severe sepsis study group. Sepsis syndrome:a valid clinical entity. Crit Care Med 1989,17: 389-93.
4. Burgie R J, Lamont P M, Kwiatkowski D et al. Systemic cytokine response after major surgery. Br J Surg 1992; 79: 757-60.
5. Colley C M, Fleck A, Goode Act al. Early time course of the acute phase protein response in man. J Clin Pathol 1983; 36: 203-7.
6. Cruickshank A M, Fraser W D, Burns H J G, et al. Response of serum IL-6 in patients undergoing elective surgery of varying severity. Clin Sci 1990; 79: 161-5.
7. Gauldie J, Richards C, Harnish D et al. Interferon B is identical to monocyte HSF and regulates the full acute phase protein response in liver cells. In: Monokines and other non-lymphocytic cytokines. (Eds. Powanda J C, Oppenheim J J, Kluger M J, Dinarello C A). Alan R Liss, Inc, New York 1988: 15-20.
8. Gauldie J, Northemann W, Fey GH. IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6. J Immunology 1990 144: 3804-8.
9. Giannoudis P V, Smith R M, Ramsden C et al. Molecular mediators and trauma: The effect of accidental trauma on IL-6, plasma elastase, sICAM-1 and sE-selectin release. Injury 1996; 27: 372-3.
10. Giannoudis P V, Smith R M, Banks R E et al. Stimulation of inflammatory markers after blunt trauma. Shock 1997; 7: 45-6.
11. Gosling P, Dickson G R, Serum C-reactive protein in patients with serious trauma. Injury 1992; 23: 483-6.
12. Hoch C R, Rodriquez R, Manning T et al. Effects of accidental trauma on cytokine and endotoxin production. Crit Care Med 1993; 21: 839-45.
13. Kallio P, Michelsson J, Lalla M, et al. C-reactive protein in tibial fractures. J Bone Joint Surg (Br) 1990; 72: 615-7.
14. Moody BJ , Shakespeare P G, Batstone G F. The effects of septic complications upon the serum protein changes associated with thermal injury. Ann Clin Biochem 1985; 22: 391-5.
15. Niskanen R O, Korkala O, Pammo H. Serum C-reactive protein levels after total hip and knee arthroplasty. J Bone Joint Surg (Br) 1996; 78: 431-3.
16. Pepys M B. Measurements of serum amyloid A protein concentrations as a test of renal allograft rejection. Lancet 1984; 1: 859-60.
17. Pullicino E A, Carli F, Poole S et al. The relationship between circulating concentrations of interleukin 6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphokine Res 1990: 231-8.
18. Shakespeare P G, Ball A J, Spurr E D, Serum protein changes after abdominal surgery. Ann Clin Biochem 1989; 26: 49-51.
19. Waage A, Brandftzaeg P, Halstensen A et al. The complex pattern of cytokines in serum from patients with menigococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med 1989; 169: 333-8.
20. Waydhas C, Nast-Kolb D, Trupka A, et al. Posttraumatic inflammatory response, secondary operations, late multiple organ failure. J Trauma 1996; 40: 624-31.
21. Whicher J T, Dieppe P A. Acute phase proteins. Clin Immunol Allergy 1985; 5: 425-46.
22. Whicher J T, Evans S W. Acute phase proteins. Hosp Update 1990; Nov 899-905.
23. Yoon S I, Lim S S, Rha J D et al.The C-reactive protein (CRP) in patients with long bone fractures and after arthroplasty. Int Orthop (SICOT) 1993; 17: 198-201.