Disruption of the vertical calcium gradient in murine epidermis by a potent vitamin D3 analogue, KH 1060

Acta Dermato-Venereologica

Volumn 78, Issue 3, 1998, Pages 164-168

  Gniadecki, R ^a,b   Serup, J ^b   Gajkowska, B ^c  

^a Leo Pharmaceutical Products ^*  (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Analogues; Calcium gradient; Cholecalciferols; Differentiation; Epidermis; Proliferation

Indexed keywords

CALCIUM ION; COLECALCIFEROL DERIVATIVE; LEXACALCITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; EPIDERMIS; EPIDERMIS HYPERPLASIA; FEMALE; HYPERKERATOSIS; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; SECOND MESSENGER; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; BODY WATER; CALCITRIOL; CALCIUM; CELL MEMBRANE PERMEABILITY; EPIDERMIS; FEMALE; HISTOCYTOCHEMISTRY; HYPERPLASIA; IMMUNOSUPPRESSIVE AGENTS; KERATINOCYTES; KERATOSIS; MICE; MICE, INBRED C3H; MICE, INBRED HRS; MICROSCOPY, ELECTRON; SKIN; SKIN DISEASES; WATER LOSS, INSENSIBLE;

EID: 0031947109     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/000155598441440     Document Type: Article

References (36)

1. 3. Endocrinology 1983; 113: 1950-1957.
2. 3 on the morphologic and biochemical differentiation of cultured human keratinocytes grown in serum-free conditions. J Invest Dermatol 1986; 86: 709-714.
3. 3 analogue stimulates terminal differentiation and inhibits proliferation of cultured human keratinocytes. Arch Dermatol Res 1990; 282: 164-167.
4. Kragballe K. Treatment of psoriasis with calcipotriol and other vitamin D analogues. J Am Acad Dermatol 1992; 27: 1001-1008.
5. Kragballe K, Gjertsen BT, De Hoop D, Karlsmark T, van de Kerkhof PC, Larkö O, et al. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991; 337: 193-196.
6. 3) for the treatment of psoriasis. Br J Dermatol 1996; 134: 1070-1078.
7. 3. Br J Pharmacol 1994; 113: 439-444.
8. 3 and the vitamin D analogue KH1060 induce hyperproliferation in normal mouse epidermis. A BrdUrd/ DNA flow cytometric study. Exp Dermatol 1993; 2: 113-120.
9. 3: dependence on cell culture conditions. J Invest Dermatol 1996; 106: 510-516.
10. 3 hormone, on hairless mouse skin in vivo. Br J Dermatol 1995; 132: 841-852.
11. 3. Biochem Pharmacol 1995; 49: 621-624.
12. 3 analogue KH-1060. Acta Derm Venereol (Stockh) 1995; 75: 222-227.
13. Gniadecki R. A vitamin D analogue KH 1060 activates the protein kinase C-c-fos signalling pathway to stimulate epidermal proliferation in murine skin. J Endocrinol 1994; 143: 521-525.
14. 3: role of protein kinase C translocation. Biochem Biophys Res Commun 1989; 163: 1517-1522.
15. 3. Mol Cell Endocrinol 1993; 90: 231-238.
16. 3 in bone. J Biol Chem 1992; 267: 12562-12569.
17. Khare S, Wilson DM, Tien X-Y, Dudeja PK, Wali RK, Sitrin MD, Brasitus TA. 1,25-dihydroxycholecalciferol rapidly activates rat colonie particulate guanylate cyclase via a protein kinase C-dependent mechanism. Endocrinology 1993; 133: 2213-2219.
18. 3. J Biol Chem 1995; 270: 6639-6643.
19. 2+-independent isoforms of protein kinase C in rat colono-cytes. J Clin Invest 1995; 95: 2215-2221.
20. 2+ uptake in skeletal muscle by protein kinase C. Biochem J 1992; 281: 349-352.
21. 3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways. J Steroid Biochem Molec Biol 1992; 41: 231-240.
22. Clapham DE. Calcium signaling. Cell 1995; 80: 259-268.
23. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest 1996; 97: 1085-1093.
24. Bikle DD, Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocr Rev 1993; 14: 3-19.
25. 3. Biochem J 1993; 289: 675-679.
26. 3 evokes oscilla-tions of intracellular calcium in a pancreatic β-cell line. Endocrinology 1995; 136: 2852-2861.
27. 3 metabolites on cytosolic free calcium in confluent mouse osteoblasts. J Biol Chem 1987; 262: 13168-13173.
28. 3 stimulation of calcium uptake by rat intestinal cells involves a dihydropyridine-sensitive cAMP-dependent pathway. Cell Signal 1994; 6: 299-304.
29. Jones KT, Sharpe GR. Intracellular free calcium and growth changes in single human keratinocytes in response to vitamin D and five 20-epi-analogues. Arch Dermatol Res 1994; 286: 123-129.
30. 3 upregulates the phosphatidylinositol signalling pathway in human keratinocytes by increasing phospholipase C levels. J Clin Invest 1995; 96: 602-609.
31. Gajkowska B, Zareba-Kowalska A. Cytochemical calcium localization in hypothalamo-neurohypophysial system of rats after ischemia. Preliminary observations. J Hirnforsch 1989; 6: 747-755.
32. Menon GK, Grayson S, Elias PM. Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 1985; 84: 508-512.
33. Pinnagoda J, Tupker RA. Measurement of the transepidermal water loss. In: Serup J, Jemec GBE, eds. Non-invasive methods and the skin. Boca Raton, FL: CRC Press, 1995: 173-178.
34. Menon GK, Elias PM, Feingold KR. Integrity of the permeability barrier is crucial for maintenance of the epidermal calcium gradient. Br J Dermatol 1994; 130: 139-147.
35. Menon GK, Elias PM. Ultrastructural localization of calcium in psoriatic and normal human epidermis. Arch Dermatol 1991; 127: 57-63.
36. Pillai S, Menon GK, Bikle DD, Elias PM. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. J Cell Physiol 1993; 154: 101-112.