Bronchoscintigraphy and pulmonary clearance of 99mTc-albumin colloid in the study of mucociliary clearance

Danish Medical Bulletin

Volumn 45, Issue 2, 1998, Pages 195-209

  Mortensen, Jann ^a  

^a H:S Bispebjerg Hhospital ^*

Author keywords

[No Author keywords available]

Indexed keywords

TECHNETIUM 99M;

BRONCHOSCOPY; BRONCHUS MUCOSA; CILIARY MOTILITY; DRUG CLEARANCE; HUMAN; ISOTOPE LABELING; LUNG CLEARANCE; REVIEW;

ADMINISTRATION, INHALATION; BRONCHI; CLINICAL TRIALS; COLLOIDS; HUMANS; LUNG; MUCOCILIARY CLEARANCE; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M AGGREGATED ALBUMIN;

EID: 0031946124     PISSN: 09078916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (149)

1. Groth S, Mortensen J, Lange P, Munch EP, Soørensen PG, Rossing N. Imaging of the airways by bronchoscintigraphy for the study of mucociliary clearance. Thorax 1988; 43: 360-365.
2. Mortensen J, Groth S, Lange P, Rossing N. Bronchoscintigraphic visualization of the acute effect of tobacco exposure and terbutaline on mucociliary clearance in smokers. Eur Respir J 1989; 2: 721-726.
3. Mortensen J, Groth S, Lange P, Hermansen F. Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Thorax 1991; 46: 817-823.
4. 2-adrenergic agonists on lung mucociliary clearance in patients with cystic fibrosis. Chest 1993; 103: 805-811.
5. Mortensen J, Falk M, Groth S, Jensen C. The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis. Chest 1991; 100: 1350-1357.
6. Mortensen J, Jensen C, Groth S, Lange P. The effect of forced expirations on mucociliary clearance in patients with chronic bronchitis and in healthy subjects. Clin Physiol 1991; 11: 439-450.
7. Mortensen J, Lange P, Nyboe J, Groth S. Lung mucociliary clearance. Eur J Nucl Med 1994; 21: 953-961.
8. Gamsu G, Singer MM, Vincent HH, Berry S, Nadel JA. Postoperative impairment of mucous transport in the lung. Am Rev Respir Dis 1976; 114: 673-9.
9. Wanner A, Salathé M, O'Riordan TG. Mucociliary clearance in the airways. Am J Respir Crit Care Med 1996; 154: 1868-1902.
10. Konrad F, Schreiber T, Brecht-Kraus D, Georgieff M. Mucociliary transport in ICU patients. Chest 1994; 105; 237-41.
11. Camner P, Mossberg B. Airway mucus clearance and mucociliary transport. In: Aerosols in Medicine, Principles, Diagnosis and Therapy: 2nd edition. Morén F et al., eds. Elsevier, Amsterdam, the Netherlands 1993, pp 247-60.
12. Satir P, Sleigh MA. The physiology of cilia and mucociliary interactions. Annu Rev Physiol 1990; 52: 137-55.
13. Serafini SM, Michaelson ED. Length and distribution of cilia in human and canine airways. Bull Europ Physiopath Resp 1977; 13: 551-9.
14. Wong LB, Miller IF, Yeates DB. Stimulation of ciliary beat frequency by autonomic agonists: in vivo. J Appl Physiol 1988; 65: 971-81.
15. Clarke SW, Yeates DB. Deposition and clearance. In: Textbook of respiratory medicine: 2nd edition. Murray JF, Nadel JA, eds. WB Saunders Company, Philadelphia, Pennsylvania 1994, pp 345-69.
16. Reid L, Bhaskar K, Coles S. Clinical aspects of respiratory mucus. In: Advances in experimental medicine and biology. Chantier EN, Elder JB, Elstein M, eds. Plenum Press, New York 1982; 144: 369-91.
17. Welsh MJ. Electrolyte transport by airway epithelia. Physiological Reviews 1987; 67: 1143-84.
18. Basbaum C, Welsh MJ. Mucous secretion and ion transport in airways. In: Textbook of respiratory medicine: 2nd edition. Murray JF, Nadel JA, eds. WB Saunders Company, Philadelphia, Pennsylvania 1994, pp 323-44.
19. Iravani J, Van As A. Mucus transport in the tracheobronchial tree of normal and bronchitic rats. J Pathol 1972; 106: 81-93.
20. Stewart WC. Weight-carrying capacity and excitability of excised ciliated epithelium. Am J Physiol 1948; 152: 1-5.
21. Yeates DB. Mucus theology. In: The lung: Scientific foundations. Crystal RG, West JB et al., eds. Raven Press, New York 1991, pp 197-203.
22. Wong LB, Miller IF, Yeates DB. Regulation of ciliary beat frequency by autonomic mechanisms: in vitro. J Appl Physiol 1988; 65: 1895-1901.
23. 2 purinoceptor regulation of mucin release by airway goblet cells in primary culture. Br J Pharmacol 1991; 103: 1053-6.
24. Wong LB, Yeates DB. Luminal purinergic regulatory mechanisms of tracheal ciliary beat frequency. Am J Respir Cell Mol Biol 1992; 7: 447-54.
25. Lundgren JD. Mucus production in the lower airways (Thesis). Lægeforeningens forlag, Copenhagen, 1992.
26. Corssen G, Allen CR. Acetylcholine: its significance in controlling ciliary activity of human respiratory epithelium in vitro. J Appl Physiol 1959; 14: 901-4.
27. Partanen M, Laitinen A, Hervonen A, Toivanen M, Laitinen LA. Catecholamine- and acetylcholinesterase-containing nerves in human lower respiratory tract. Histochemistry 1982; 76: 175-88.
28. Phipps RJ, Williams IP, Richardson PS, Pell J, Pack RJ, Wright N. Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro. Clin Sci 1982; 63: 23-8.
29. Barnes PJ. Neural control of human airways in health and disease. Am Rev Respir Dis 1986; 134: 1289-1314.
30. Wagner U, von Wichert P. Control of mucus secretion in airways. Respiration 1991; 58: 1-8.
31. Hesse H, Kasparek R, Mizera W, Unterholzner Ch, Konietzko N. Influence of Reproterol on ciliary beat frequency of human bronchial epithelium in vitro. Arzneim-Forsch/Drug Res 1981; 31: 716-8.
32. Devalia JL, Sapsford RJ, Rusznak C, Toumbis MJ, Davies RJ. The effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells, in vitro. Pulmonary Pharmacol 1992; 5: 257-63.
33. 2-adrenoceptor stimulants in the control of ciliary activity. Respiration 1974; 31: 146-51.
34. Sanderson MJ, Dirksen ER. Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am Rev Respir Dis 1989; 139: 432-40.
35. Tamaoki J, Chiyotani A, Kondo M, Konno K, Role of NO generation in β-adrenoceptor-mediated stimulation of rabbit airway ciliary motility. Am J Physiol 1995; 268 (Cell Physiol 37): C1342-7.
36. + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 1986; 78: 1245-52.
37. Kaliner M (moderator), Shelhamer JH, Borsen B, Nadel J, Patow C, Marom Z, (discussants). Human respiratory mucus. Am Rev Respir Dis 1986; 134: 612-21.
38. Seybold ZV, Mariassy AT, Stroh D, Kim CS, Gazeroglu H, Wanner A. Mucociliary interaction in vitro: effects of physiological and inflammatory stimuli. J Appl Physiol 1990; 68: 1421-6.
39. Camner P, Mossberg B, Philipson K, Strandberg K. Elimination of test particles from the human tracheobronchial tract by voluntary coughing. Scand J Respir Dis 1979; 60: 56-62.
40. Puchelle E, Zahm JM, Girard F, Bertrand A, Polu JM, Aug F, Sadoul P. Mucociliary transport in vivo and in vitro. Relations to sputum properties in chronic bronchitis. Eur J Respir Dis 1980; 61: 254-64.
41. Matthys H. Bronchial clearance measurement with radioaerosols in humans, In: Methods in bronchial mucology. Braga PC, Allegra L, eds. Raven Press, New York 1988, pp 377-93.
42. Newhouse MT, Wright FJ, Dolovich M, Hopkins OL. Clearance of RISA aerosol from the human lung. In: Airway Dynamics. Bouhuys A, ed. Springfield, CC Thomas Publisher, 1970. pp 313-7.
43. Isawa T, Teshima T, Hirano T, Ebina A, Konno K. Mucociliary clearance mechanism in smoking and nonsmoking normal subjects. J Nucl Med 1984; 25: 352-9.
44. 36b. Johnson LG, Cheng PW, Boucher RC. Albumin absorption by canine bronchial epithelium. J Appl Physiol 1989; 66: 2772-7.
45. List SJ, Findlay BP, Forstner GG, Forstner JF. Enhancement of the viscosity of mucin by serum albumin. Biochem J 1978; 175: 565-71.
46. Yeates DB, Aspin N, Levison H, Jones MT, Bryan AC. Mucociliary tracheal transport rates in man. J Appl Physiol 1975; 39: 487-95.
47. Felix R, Hedde JP, Zwicker HJ, Winkler C. Mukociliäre Klärfunktion unter β-adrenerger Stimulation mit Fenoterol. Prax Pneumol 1978; 32: 777-82.
48. Lafortuna CL, Fazio F. Acute effect of inhaled salbutamol on mucociliary clearance in health and chronic bronchitis. Respiration 1984; 45: 111-23.
49. Shankar S, Fulsham L, Read RC, Theodoropoulos S, Cole PJ, Madden B, Yacoub M. Mucociliary function after lung transplantation. Transplantation Proceedings 1991; 23: 1222-3.
50. Olséni L. Evaluation of mucus transport in human airways with special reference to physiotherapy (Thesis). University of Lund, Lund, Sweden, 1993.
51. Pavia D, Short MD, Thomson ML. No demonstrable long term effects of cigarette smoking on the mucociliary mechanism of the human lung. Nature 1970; 226: 1228-31.
52. Camner P, Philipson K, Arvidsson T. Cigarette smoking in man. Short-term effect on mucociliary transport. Arch Environ Health 1971; 23: 421-6.
53. Yeates DB, Pitt BR, Spektor DM, Karron GA, Albert RE. Coordination of mucociliary transport in human trachea and intrapulmonary airways. J Appl Physiol 1981; 51: 1057-64.
54. Vastag E, Matthys H, Köhler D, Gronbeck L, Daikeler G. Mucociliary clearance and airways obstruction in smokers, ex-smokers and normal subjects who never smoked. Eur J Respir Dis 1985; 66 (suppl 139): 93-100.
55. Connolly TP, Noujaim AA, Man SFP. Simultaneous canine tracheal transport of different particles. Am Rev Respir Dis 1978; 118: 965-8.
56. Lee TK, Man SFP, Connolly TP, Noujaim AA. Simultaneous comparison of canine tracheal transport of anion exchange resin particles to albumin macroaggregates and sulfur colloid: Effects of subcutaneous methacholine chloride and intravenous hypertonic saline. Am Rev Respir Dis 1980; 121: 487-94.
57. Ilowite JS, Smaldone GC, Perry RJ, Bennett WD, Foster WM. Relationship between tracheobronchial particle clearance rates and sites of initial deposition in man. Arch Environ Health 1989; 44: 267-73.
58. Lippmann M. Regional deposition of particles in the human respiratory tract. In: Lee DHK, Murphy SD, eds. Handbook of physiology, sect 9, Reactions to environmental agents. Bethesda, Am Physiol Soc, 1977, pp 213-32.
59. Brain JD, Valberg PA. Deposition of aerosol in the respiratory tract. Am Rev Respir Dis 1979; 120: 1325-73.
60. Agnew JE. Physical properties and mechanisms of deposition of aerosols. In: Clarke SW & Pavia D, eds. Aerosols and the lung. London: Butter-worths, 1984, pp 49-70.
61. Lippmann M, Albert RE. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J 1969; 30: 257-75.
62. Santa Cruz R, Landa J, Hirsch J, Sackner MA. Tracheal mucous velocity in normal man and patients with obstructive lung disease; Effects of terbutaline. Am Rev Respir Dis 1974; 109: 458-63.
63. Sackner MA, Landa J, Hirsch J, Zapata A. Pulmonary effects of oxygen breathing. A 6- hour study in normal men. Ann Intern Med 1975; 82: 40-3.
64. Goodman RM, Yergin BM, Landa JF, Golinvaux MH, Sackner MA. Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis. Am Rev Respir Dis 1978; 117: 205-14.
65. Thomson ML, Short MD. Mucociliary function in health, chronic obstructive airway disease, and asbestosis. J Appl Physiol 1969; 26: 535-9.
66. Miyano M, Nakamura M, Yamaya M, Fukushima T, Sekizawa K, Sasaki H, Takishima T. Series distribution of mucociliary clearance of magnetized iron particles in anesthetized dogs. Respir Physiol 1990; 79: 9-18.
67. Agnew JE, Lopez-Vidriero MT, Pavia D, Clarke SW. Functional small airways defence in symptomless cigarette smokers. Thorax 1986; 41: 524-30.
68. Agnew JE, Bateman JRM, Pavia D, Clarke SW. A model for assessing bronchial mucus transport. J Nucl Med 1984; 24: 170-6.
69. Bailey MR. Human data on clearance. In: Lung modelling for inhalation of radioactive materials. Proceedings of a meeting jointly organised by the Commission of the European Communities and the National Radiological Protection Board. Smith H, Gerber G, eds. Oxford, 26-28 March 1984, pp 93-110.
70. Lourenco RV, Klimek MF, Borowski CJ. Deposition and clearance of 2 μ particles in the tracheobronchial tree of normal subjects - smokers and nonsmokers. J Clin Invest 1971; 50: 1411-20.
71. Camner P, Philipson K. Human alveolar deposition of 4 μm teflon particles. Arch Environ Health 1978; 33: 181-5.
72. Yeates DB, Gerrity TR, Garrard CS. Characteristics of tracheobronchial deposition and clearance in man. Inhaled Particles V, Ann Occup Hyg 1982; 26: 245-57.
73. Svartengren M, Anderson M, Bylin G, Philipson K, Camner P. Regional deposition of 3.6 μm particles in subjects with mild to moderately severe asthma. J Aerosol Med 1990; 3: 197-207.
74. Svartengren M, Philipson K, Linnman L, Camner P. Regional deposition of particles in human lung after induced bronchoconstriction. Exp Lung Res 1986; 10: 223-33.
75. Svartengren M, Linnman L, Philipson K, Camner P. Regional deposition in human lung of 2.5 μm particles. Exp Lung Res 1987; 12: 265-79.
76. Ruusa J, Svartengren M, Philipson K, Camner P. Tracheobronchial panicle deposition and clearance in immotile cilia syndrome patients. J Aerosol Med 1993; 6 (2): 89-98.
77. Ericsson CH, Svartengren K, Svartengren M, Mossberg B, Philipson K, Blomquist M, Camner P. Repeatability of airway deposition and tracheobronchial clearance rate over three days in chronic bronchitis. Eur Respir J 1995; 8: 1886-93.
78. Pavia D. Lung mucociliary clearance. In: Aerosols and the lung. Clarke SW, Pavia D, eds. London: Butterworths, 1984, pp 127-55.
79. Puchelle E, Zahm JM, Bertrand A. Influence of age on bronchial mucociliary transport. Scand J Respir Dis 1979; 60: 307-13.
80. Sutton PP, Parker RA, Webber BA, Newman SP, Garland N, Lopez-Vidriero MT, Pavia D, Clarke SW. Assessment of the forced expiration technique, postural drainage and directed coughing in chest physiotherapy. Eur J Respir Dis 1983; 64: 62-8.
81. Oldenburg FA jr. Dolovich MB, Montgomery JM, Newhouse MT. Effects of postural drainage, exercise, and cough on mucus clearance in chronic bronchitis. Am Rev Respir Dis 1979; 120: 739-45.
82. Albert RE, Lippmann M, Peterson HT, Berger J, Sanborn K, Bohning D. Bronchial deposition and clearance of aerosols. Arch Intern Med 1973; 131: 115-27.
83. Svartengren M, Mossberg B, Philipson K, Camner P. Mucociliary clearance in relation to clinical features in patients with bronchiectasis. Eur J Respir Dis 1986; 68: 267-78.
84. Van Hengstum M, Festen J, Buijs W, van den Broek W, Corstens F. Variability of tracheobronchial clearance in healthy non-smoking subjects. Respiration 1989; 56: 94-102.
85. Foster WM, Langenback EG, Bergofsky EH. Measurement of tracheal and bronchial mucus velocities in man: relation to lung clearance. J Appl Physiol 1980; 48: 965-71.
86. Todisco T, Polidori R, Rossi F, lannacci L, Bruni B, Fedeli L, Palumbo R. Effect of N-acetylcysteine in subjects with slow pulmonary mucociliary clearance. Eur J Respir Dis 1985; 66 (suppl 139): 136-41.
87. Agnew JE, Sutton PP, Pavia D, Clarke SW. Radioaerosol assessment of mucociliary clearance: towards definition of a normal range. Br J Radiol 1986; 59: 147-51.
88. Matthys H, Köhler D. Daikeler G, Fischer J, Vastag E. Mukoziliäre Clearance bei Patienten mit zentralem und peripherem Bronchialkarzinom. Prax Klin Pneumol 1983; 37: 1004-7.
89. 99cm pertechnetate for brain scanning. J Nucl Med 1961; 5: 811-27.
90. 99cm labels. Am J Roentgenol 1967; 100: 813-21.
91. Yeates DB, Aspin N, Bryan AC, Levison H. Regional clearance of ions from the airways of the lung. Am Rev Respir Dis 1973; 107: 602-8.
92. Yeates DB, Spektor DM, Pitt BR. Effect of orally administered orciprenaline on tracheo-bronchial mucociliary clearance. Eur J Respir Dis 1986; 69: 100-8.
93. ICRP Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Hlth Phys 1966; 12: 173-207.
94. Mortensen J, Groth S, Lange P, Rossing N. Towards highly selective bronchial deposition of radioaerosols. J Aerosol Med 1988; 1: 230-1.
95. Mortensen J, Milman N, Faurschou P, Engel AM, Nissen FH. Observer variation in radioaerosol studies of lung mucociliary clearance. Eur Respir J 1996; 9 (suppl 23): 279s.
96. Mortensen J, Engel AM, Milman N, Nissen F, Faurschou P. Inhaled terbutaline improves mucociliary clearance in patients with bronchiectasis. Eur Respir J 1992; 5 (suppl 15): 385s.
97. Gjørup T, Brahm M. Fogh J, Munck O, Jensen AM. Interobserver variation in the detection of metastasis on liver scans. Gastroenteroloey 1986; 90: 166-72.
98. Hertev Hospital Study Group. Diagnostic decision-process in suspected pulmonary embolism. Lancet 1979; i: 1336-8.
99. Rabøl A, Hesse B, Fogh J. Perfusion/ventilation scintiphotography in suspected pulmonary embolism. Lancet 1981; i: 1427.
100. Rossing N, Munck O, Nielsen SP, Andersen KW. What do early bone scans tell about breast cancer patients? Eur J Cancer Clin Oncol 1982; 18: 629-36.
101. Chinn S. Repeatability and method comparison. Thorax 1991; 46; 454-6.
102. Zwas ST, Katz I, Belfer B, Baum GL, Aharonson E. Scintigraphic monitoring of mucociliary tracheo-bronchial clearance of technetium-99m macroaggregated albumin aerosol. J Nucl Med 1987; 28: 161-7.
103. Hasani A, Vora H, Pavia D, Agnew JE, Clarke SW. No effect of gender on lung mucociliary clearance in young healthy adults. Respir Med 1994; 88: 697-700.
104. Sackner MA, Yergin BM, Brito M, Januszkiewicz A. Effect of adrenergic agonists on tracheal mucous velocity. Bull Europ Physiopath Resp 1979; 15: 505-11.
105. Foster WM, Bergofsky EH, Bohning DE, Lippmann M, Albert RE. Effect of adrenergic agents and their mode of action on mucociliary clearance in man. J Appl Physiol 1976; 41: 146-52.
106. Foster WM, Langenback EG, Bergofsky EH. Disassociation in the mucociliary function of central and peripheral airways of asymptomatic smokers. Am Rev Respir Dis 1985; 132: 633-9.
107. Perry RJ, Smaldone GC. Effect of bronchodilators on mucociliary clearance in normal adults. J Aerosol Med 1990; 3: 187-96.
108. 2-stimulator really facilitate mucociliary transport in the human lungs in vivo? A study with procaterol. Am Rev Respir Dis 1990; 141: 715-20.
109. Konietzko N, Klopfer M, Adam WE, Matthys H. Die mukociliare Klärfunktion der Lunge unter β-adrenerger Stimulation. Pneumologie 1975; 152: 203-8.
110. Sackner MA, Landa J, Hirsch J, Zapata A. Pulmonary effects of oxygen breathing. A 6-hour study in normal men. Ann Intern Med 1975; 82: 40-3.
111. Camner P, Strandberg K, Philipson K. Increased mucociliary transport by adrenergic stimulation. Arch Environ Health 1976; 31: 79-82.
112. Pavia D, Agnew JE, Sutton PP, Lopez-Vidriero MT, Clay MM, Killip M, Clarke SW. Effect of terbutaline administered from metered dose inhaler (2 mg) and subcutaneously (0.25 mg) on tracheobronchial clearance in mild asthma. Br J Dis Chest 1987; 81: 361-70.
113. Bohning DE, Albert RE, Lippmann M, Cohen VR. Effects of flourocarbons 11 and 12 on tracheobronchial particle deposition and clearance in donkeys. Am Ind Hyg Assoc J 1975; 36: 902-8.
114. Bateman JRM, Pavia D, Sheahan NF, Newman SP, Clarke SW. Effects of terbutaline sulphate aerosol on bronchodilator response and lung mucociliary clearance in patients with mild stable asthma. Br J Clin Pharmacol 1983; 15: 695-700.
115. Newman SP, Morén F, Trofast E, Talaee N, Clarke SW. Deposition and clinical efficacy of terbutaline sulphate from Turbuhaler. a new multidose powder inhaler. Eur Respir J 1989; 2: 247-52.
116. Borgström L. Methodological studies on lung deposition. Evaluation of inhalation devices and absorption mechanisms (Thesis). Acta Univ. Ups., 1993.
117. Borgström L, Newman S. Total and regional lung deposition of terbutaline sulphate inhaled via a pressurised MDI or via Turbuhaler. Int J Pharmaceut 1993; 97: 47-53.
118. Newman S, Steed K, Hooper G, Källén A, Borgström L. Comparison of gamma scintigraphy and a pharmacokinetic technique for assessing pulmonary deposition of terbutaline sulphate delivered by pressurized metered dose inhaler. Pharm Res 1995; 12: 231-6.
119. Mossberg B, Strandberg K, Philipson K, Camner P. Tracheobronchial clearance in bronchial asthma: response to beta-adrenoceptor stimulation. Scand J Respir Dis 1976; 57: 119-28.
120. Mossberg B, Strandberg K, Philipson K, Camner P. Tracheobronchial clearance and beta-adrenoceptor stimulation in patients with chronic bronchitis. Scand J Respir Dis 1976; 57: 281-9.
121. Ohnuki M, Ito S, Imai T, et al. The immediate effect of terbutaline sulphate, a β-adrenoceptor stimulating agent, on the mucociliary transport system. Jpn J Chest Dis 1990; 49: 536-41.
122. Trevisani L, Sartori S, Pazzi P, Potena A, Aleotti A, Grandi E, Stabellini G. Acquired ciliary defects in bronchial epithelium of patients with chronic bronchitis. Respiration 1990; 57: 6-13.
123. Nadel JA, Comroe JH jr. Acute effects of inhalation of cigarette smoke on airway conductance, J Appl Physiol 1961; 16: 713-6.
124. Pavia D, Thomson ML, Pocock SJ. Evidence for temporary slowing of mucociliary clearance in the lung caused by cigarette smoking. Nature 1971; 231: 325-6.
125. Stanley PJ, Wilson R, Greenstone MA, Macwilliam L, Cole PJ. Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax 1986; 41: 519-23.
126. Vastag E, Matthys H, Zsamboki G, Köhler D, Daikeler G. Mucociliary clearance in smokers. Eur J Respir Dis 1986; 68: 107-13.
127. Auerbach O, Stout AP, Hammond EC, Garfinkel L. Changes in bronchial epithelium in relation to smoking habits. Act Un Canc 1964; 20: 732-6.
128. Camner P, Mossberg B, Philipson K. Tracheobronchial clearance and chronic obstructive lung disease. Scand J Respir Dis 1973 ; 54: 272-81.
129. Lange P. Development and prognosis of chronic obstructive pulmonary disease with special reference to the role of tobacco smoking (Thesis). Lægeforeningens forlag, Copenhagen, 1991.
130. Camner P, Philipson K, Arvidsson T. Withdrawal of cigarette smoking. A study on tracheobronchial clearance. Arch Environ Health 1973; 26: 90-2.
131. Kaminski EJ, Fancher OE, Calandra JC. In vivo studies of the ciliastatic effects of tobacco smoke. Arch Environ Health 1968; 16: 188-93.
132. Iravani J, Melville GN. Wirkung von Pharmaka und Milieuänderungen auf die Flimmertätigkeit der Atemwege. Respiration 1975; 32: 157-64.
133. Hee J, Guillerm R. Discussion on smoke and mucociliary transport. Eur J Respir Dis 1985; 66 (suppl 139): 86-8.
134. Peatfield AC, Davies JR, Richardson PS. The effect of tobacco smoke upon airway secretion in the cat. Clin Sci 1986; 71: 179-87.
135. Ramsey BW. Management of pulmonary disease in patients with cystic fibrosis. N Engl J Med 1996; 335: 179-88.
136. Bennett WD, Zeman KL. Effect of supramaximal flows on cough clearance. J Appl Physiol 1994; 77: 1577-83.
137. Hasani A, Pavia D, Agnew JE, Clarke SW. Regional mucus transport following unproductive cough and forced expiration technique in patients with airways obstruction. Chest 1994; 105: 1420-5.
138. Smaldone GC. Lung mechanics and mucociliary clearance. In: Aerosols: Formation and reactivity, 2nd Int. Aerosol Conf Berlin. Pergamon Journals, Great Britain 1986, pp 175-81.
139. Bennett WD, Foster WM, Chapman WF. Cough-enhanced mucus clearance in the normal lung. J Appl Physiol 1990; 69: 1670-5.
140. Prescott E, Lange P, Vestbo J. Chronic mucus hypersecretion in COPD and death from pulmonary infection. Eur Respir J 1995; 8: 1333-8.
141. Lange P, Ulrik CS, Vestbo J. Mortality in adults with self-reported asthma. Lancet 1996; 347: 1285-9.
142. Desmond KJ, Schwenk WF, Thomas E, Beaudry PH, Coates AL. Immediate and long-term effects of chest physiotherapy in patients with cystic fibrosis. J Pediatr 1983; 103: 538-42.
143. Oberwaldner B, Evans JC, Zach MS. Forced expirations against a variable resistance: A new chest physiotherapy method in cystic fibrosis. Pediatr Pulmonol 1986; 2: 358-67.
144. Ricksten SE, Bengtsson A, Soderberg C, Thorden M, Kvist H. Effects of periodic positive airway pressure by mask on postoperative pulmonary function. Chest 1986; 89: 774-81.
145. Christensen EF, Nedergaard T, Dahl R. Long-term treatment of chronic bronchitis with positive expiratory pressure mask and chest physiotherapy. Chest 1990; 97: 645-50.
146. Kanthakwmar K, Cundell DR, Johnson M, Wills PJ, Taylor GW, Cole PJ, Wilson R. Effect of salmeterol on human nasal epithelial cell ciliary beating: inhibition of the ciliotoxin, pyocyanin. Br J Pharmacol 1994; 112: 493-8.
147. Sykes DA, Chan KL, Wilson R, Mackay IS, Cole PJ. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. Lancet 1986; 2: 359-60.
148. Sisson JH, Reed EC, Robbins RA, Anderson JR, Ogren FP, Diamond JS, Rennard SI. Impairment of nasal mucociliary clearance during bone marrow transplantation. Bone Marrow Transplantation 1994; 13: 631-3.
149. Quanjer PH. Standardized lung function testing. Report of Working Party on Standardization of Lung Function Tests of the European Community for Coal and Steel. Bull Eur Physiopath Resp 1983; 19(suppl 5), pp 1-95.