Glucagon treatment interferes with an early step of duck hepatitis B virus infection

Journal of Virology

Volumn 72, Issue 4, 1998, Pages 2600-2606

  Hild, Marc ^a,c   Weber, Olaf ^b,c   Schaller, Heinz ^c  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b BAYER AG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CIRCULAR DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GENE PRODUCT; GLUCAGON; VIRUS DNA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DUCK; ENZYME ACTIVITY; HEPATITIS B; HEPATITIS B VIRUS; INTERNALIZATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRION; VIRUS CAPSID; VIRUS GENE; VIRUS GENOME; VIRUS INHIBITION; VIRUS INTERFERENCE;

EID: 0031946003     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.4.2600-2606.1998     Document Type: Article

References (34)

1. Bartenschlager, R., M. Weber, and H. Schaller. 1994. In vitro phosphorylation of the hepatitis B virus P gene product: a general method for radiolabelling of proteins, p. 391-401. In K. W. Adolph (ed.), Methods in molecular genetics, vol. 4. Academic Press, Inc., New York, N.Y.
2. Chijiwa, T., A. Mishima, M. Hagiwara, M. Sano, K. Hayashi, T. Inoue, K. Naito, T. Toshioka, and H. Hidaka. 1990. Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265:5267-5272.
3. Civitico, G. M., and S. A. Locarnini. 1994. The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures. Virology 203:81-89.
4. de Souza, N. J., A. N. Dohadwalla, and J. Reden. 1983. Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Med. Res. Rev. 3:201-219.
5. Galle, P. R., H. J. Schlicht, C. Kuhn, and H. Schaller. 1989. Replication of duck hepatitis B virus in primary hepatocytes and its dependence on the state of differentiation of the host cell. Hepatology 10:459-465.
6. Giuidotti, L. G., T. Ishikawa, M. V. Hobbs, B. Matzke, R. Schreiber, and F. V. Chisari. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25-36.
7. Hild, M. 1997. Zelluläre Funktionen während der frühen und späten Schritte im Infektionszyklus des Enten Hepatitis B Virus. Ph.D. thesis. University of Heidelberg, Heidelberg, Germany.
8. Hildt, E. 1996. The hepatitis B virus large surface protein (LHBs) is a transcriptional activator. Virology 225:235-239.
9. Houge, G., O. K. Vintermyr, and S. O. Doskeland. 1990. The expression of cAMP-dependent protein kinase subunits in primary rat hepatocyte cultures. Cyclic AMP down-regulates its own effector system by decreasing the amount of catalytic subunit and increasing the mRNAs for the inhibitory (R) subunits of cAMP-dependent protein kinase. Mol. Endocrinol. 4:481-488.
10. Huang, R. D., M. F. Smith, and W. L. Zahler. 1982. Inhibition of forskolin-activated adenylate cyclase by ethanol and other solvents. J. Cyclic Nucleotide Res. 8:385-394.
11. Kann, M., A. Bischof, and W. H. Gerlich. 1997. In vitro model for the nuclear transport of the hepadnavirus genome. J. Virol. 71:1310-1316.
12. Klingmüller, U., and H. Schaller. 1993. Hepadnavirus infection requires the interaction between the viral pre-S domain and a specific hepatocellular receptor. J. Virol. 67:7414-7422.
13. Köck, J., and H.-J. Schlicht 1993. Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity. J. Virol. 67:4867-4874.
14. Köck, J., E.-M. Borst, and H. J. Schlicht. 1996. Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment. J. Virol. 70:5827-5831.
15. Mason, W. S., and C. Seeger (ed.). 1991. Hepadnaviruses. Molecular biology and pathogenesis. Current topics in microbiology and immunology, vol. 168. Springer-Verlag KG, Berlin, Germany.
16. McLachlan, A. (ed.). 1991. Molecular biology of the hepatitis B virus. CRC Press, Inc., Boca Raton, Fla.
17. Nassal, M., and H. Schaller. 1996. Hepatitis B virus replication - an update. J. Viral Hepatitis 3:217-226.
18. Posternak, T., and G. Weimann. 1974. The preparation of acylated derivatives of cyclic nucleotides. Methods Enzymol. 38:399-409.
19. Premont, R. T., and R. Iyengar. 1988. Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. J. Biol. Chem. 263:16087-16095.
20. Rigg, R. J., and H. Schaller. 1992. Duck hepatitis B virus infection of hepatocytes is not dependent on low pH. J. Virol. 66:2829-2836.
21. Rothmann, K., E. Hildt, and H. Schaller. 1997. Unpublished data.
22. Rothmann, K., M. Schnölzer, G. Radziwill, and H. Schaller. 1997. Unpublished data.
23. Schlicht, H. J., C. Kuhn, B. Guhr, R. J. Mattaliano, and H. Schaller. 1987. Biochemical and immunological characterization of the duck hepatitis B virus envelope proteins. J. Virol. 61:2280-2285.
24. Schlicht, H. J., J. Salfeld, and H. Schaller. 1987. The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation. J Virol. 61:3701-3709.
25. Seeger, C., E. H. Leber, L. K. Wiens, and J. Hu. 1996. Mutagenesis of a hepatitis B virus reverse transcriptase yields temperature-sensitive virus. Virology 222:430-439.
26. Sistare, F. D., R. A. Picking, and R. C. Haynes, Jr. 1985. Sensitivity of the response of cytosolic calcium in Quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides. J. Biol. Chem. 260:12744-12747.
27. Summers, J., P. M. Smith, and A. L. Horwich. 1990. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. J. Virol. 64:2819-2824.
28. Tuttleman, J. S., C. Pourcel, and J. Summers. 1986. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 47:451-460.
29. Unson, C. G., D. Andreu, E. M. Gurzenda, and R. B. Merrifield. 1987. Synthetic peptide antagonists of glucagon. Proc. Natl. Acad. Sci. USA 84: 4083-4087.
30. Unson, C. G., D. Macdonald, K. Ray, T. L. Durrah, and R. B. Merrifield. 1991. Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding. J. Biol. Chem. 266:2763-2766.
31. Wakelam, M., G. Murphy, V. Hruby, and M. D. Houslay. 1986. Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 323:68-71.
32. Weber, M. 1994. Das P-Protein des Enten Hepatitis B Virus: Untersuchungen zur Struktur und Funktion in der Hepadnaviralen Replikation. Ph.D. thesis. University of Heidelberg, Heidelberg, Germany.
33. Yu, M., and J. Summers. 1994. Phosphorylation of the duck hepatitis B virus capsid protein associated with conformational changes in the C terminus. J. Virol. 68:2965-2969.
34. Zhang, G., Y. Liu, A. E. Ruoho, and J. H. Hurley. 1997. Structure of the adenylyl cyclase catalytic core. Nature 386:247-253.