Implications of genotyping of spouses to limit investigation of children in genetic hemochromatosis

Clinical Genetics

Volumn 53, Issue 3, 1998, Pages 176-178

  Adams, Paul C ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Cost effectiveness; Hemochromatosis; HFE

Indexed keywords

TRANSFERRIN;

ARTICLE; CLINICAL GENETICS; CONSULTATION; COST CONTROL; FEMALE; FERRITIN BLOOD LEVEL; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEMOCHROMATOSIS; HETEROZYGOTE; HLA TYPING; HOMOZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PATERNITY; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SPOUSE;

EID: 0031944939     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1998.tb02672.x     Document Type: Article

References (13)

1. Bulaj ZJ, Griffen L, Jorde LB, Edwards CQ, Kushner JP. Clinical and biochemical abnormalities in people heterozygous for hemochromatosis. N Eng J Med 1996: 335: 1799-1805.
2. Borwein ST, Ghent CN, Flanagan PR, Chamberlain MJ, Valberg LS. Genetic and phenotypic expression of hemochromatosis in Canadians. Clin Invest Med 1983: 6: 171-179.
3. Adams PC. Prevalence of abnormal iron studies in heterozygotes for hereditary hemochromatosis - an analysis of 255 heterozygotes. Am J Hematol 1994: 45: 146-149.
4. Bassett ML, Halliday JW, Powell LW. HLA typing idiopathic hemochromatosis: distinction between homozygotes and heterozygotes with biochemical expression. Hepatology 1981: 1: 120-126.
5. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, et al. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996: 13: 399-408.
6. Adams PC, Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 1998: 114: 319-323.
7. Jouanolle AM, Gandon G, Jezequel P, Blayau M, Campion ML, Mosser J, Fergelot P, Chauvel B, Bouric P, Carn G, Andrieux N, Gicquel I, LeGall JY. Haemochromatosis and HLA-H. Nat Genet 1996: 14: 251-252.
8. Adams PC, Kertesz A, Valberg LS. Screening for hemochromatosis in children of homozygotes: prevalence and cost-effectiveness. Hepatology 1995: 22: 1720-1727.
9. Powell LW, Summers KM, Board PG, Axelsen E, Webb S, Halliday JW. Expression of hemochromatosis in homozygous subjects. Implications for early diagnosis and prevention. Gastroenterology 1990: 98: 1625-1632.
10. Powell LW, Bassett ML, Axelsen E, Ferluga J, Halliday JW. Is all genetic (hereditary) hemochromatosis HLA-associated? Ann NY Acad Sci 1988: 526: 23-33.
11. Jazwinska EC, Cullen LM, Busfield F, Pyper WR, Webb SI, Powell LW, Morris CP, Walsh TP. Haemochromatosis and HLA-H. Nat Genet 1996: 14: 249-251.
12. Carella M, D'Ambrosio L, Totaro A, Grifa A, Valentino M, Piperno A, Girelli D, Roetto A, Franco B, Gasparini P, Camaschella C. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients. Am J Hum Genet 1997: 60: 828-832.
13. Bacon BR, Schratz C, Britton RS, Wolff RK. Presence of the hemochromatosis genotype in patients with liver disease. Gastroenterology 1997: 112: 1218 Abstract.