Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes

Drug Metabolism and Disposition

Volumn 26, Issue 4, 1998, Pages 338-342

  Masubuchi, Yasuhiro ^b   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450; DIHYDRALAZINE; PHENACETIN O DEETHYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INACTIVATION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; TOXIC HEPATITIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDRALAZINE; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

ANIMALIA; RATTUS NORVEGICUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0031944859     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Beaune PH, Dansette PM, Mansuy D, Kiffel L, Finck M, Amar C, Leroux JP and Homberg JC (1987) Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci USA 84:551-555.
2. Boelsterli UA (1993) Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Metab Rev 25:359-451.
3. Bourdi M, Larrey D, Nataf J, Bernuau J, Pessayre D, Iwasaki M, Guengerich FP and Beaune PH (1990) Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-4501A2: A specific marker of dihydralazine-induced hepatitis. J Clin Invest 85: 1967-1973.
4. Bourdi M, Gautier JC, Mircheva J, Larrey D, Guillouzo A, Andre C, Belloc C and Beaune PH (1992) Antiliver microsomes autoantibodies and dihydralazine-induced hepatitis: Specificity of autoantibodies and inductive capacity of the drug. Mol Pharmacol 42:280-285.
5. Bourdi M, Tinel M, Beaune PH and Pessayre D (1994) Interactions of dihydralazine with cytochromes P4501A: A possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies. Mol Pharmacol 45:1287-1295.
6. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T and Mayer RT (1985) Ethoxy-, pentoxy-and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol 34:3337-3345.
7. Hinson JA and Roberts DW (1992) Role of covalent and noncovalent interactions in cell toxicity: Effects on proteins. Annu Rev Pharmacol Toxicol 32:471-510.
8. Homberg JC, Andre C and Abuaf N (1984) A new anti-liver kidney microsome antibody (anti-LKM2) in tienilic acid induced hepatitis. Clin Exp Immunol 55:561-570.
9. Imaoka S, Terano Y and Funae Y (1988) Constitutive testosterone 6β-hydroxylase in rat liver. J Biochem 104:481-487.
10. Kahn GC, Rubenfield M, Davies DS and Boobis AR (1987) Phenacetin O-deethylase activity of the rat: Strain differences and the effects of enzyme-inducing compounds. Xenobiotica 17:179-187.
11. Lecoeur S, Bonierbale E, Challine D, Gautier J-C, Valadon P, Dansette PM, Catinot R, Ballet F, Mansuy D and Beaune PH (1994) Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: Comparison with two directly hepatotoxic drugs. Chem Res Toxicol 7:434-442.
12. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
13. Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M and Narimatsu S (1994) Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes: The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos 22:909-915.
14. Masubuchi Y, Takahashi C, Fujio N, Horie T, Suzuki T, Imaoka S, Funae Y and Narimatsu S (1995) Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats. Drug Metab Dispos 23:999-1003.
15. Nataf J, Bernuau J, Larrey D, Guillin MC, Rueff B and Benhamou J-P (1986) A new anti-liver microsome antibody: A specific marker of dihydralazine-induced hepatitis. Gastroenterology 90:1751.
16. Nelson SD and Pearson PG (1990) Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals. Annu Rev Pharmacol Toxicol 30:169-195.
17. Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes: I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
18. Pariente EA, Pessayre D, Bernuau J, Degott C and Benhamou J-P (1983) Dihydralazine hepatitis: Report of a case and review of the literature. Digestion 27:47-52.
19. Pirmohamed M, Madden S and Park BK (1996) Idiosyncratic drug reactions: Metabolic bioactivation as a pathogenic mechanism. Clin Pharmacokinet 31:215-230.
20. Pohl LR (1990) Drug-induced allergic hepatitis. Semin Liver Dis 10:305-315.
21. Pohl LR, Sato H, Christ DD and Kenna JG (1988) The immunologic and metabolic basis of drug hypersensitivities. Annu Rev Pharmacol 28:367-387.
22. Pohl LR, Kenna JG, Sato H, Christ DD and Martin JL (1989) Neoantigens associated with halothane-hepatitis. Drug Metab Rev 20:203-217.
23. Riley RJ, Smith G, Wolf CR, Cook VA and Leeder JS (1993) Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s). Biochem Biophys Res Commun 191:32-40.
24. Sesardic D, Edwards RJ, Davies DS, Thomas PE, Levin W and Boobis AR (1990) High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochem Pharmacol 39:489-498.
25. Sonderfan AJ, Arlotto MP, Dutton DR, McMillen SK and Parkinson A (1987) Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch Biochem Biophys 255:27-41.