Clinical study of AJ-007 (bupivacaine) in spinal anesthesia - investigation of clinical dosase of isobaric and hyperbaric formulations

Japanese Journal of Anesthesiology

Volumn 47, Issue 4, 1998, Pages 464-465

  Suzuki, Hajime ^a,j   Ogawa, Setsuro ^a,b   Hanaoka, Kazuo ^a,b,c   Kugimiya, Toyoki ^a,b,c,d   Yokoyama, Kazuko ^a,b,c,d,e   Isshiki, Atsushi ^{a,b,c,d,e,f,g}   Hosoyamada, Akiyoshi ^{a,b,c,d,e,f,g,h}   Kikuchi, Hirosato ^{a,b,c,d,e,f,g,h,i}   Numata, Katsuo ^{a,b,c,d,e,f,g,h,i}  

^a NIHON UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JUNTENDO UNIVERSITY HOSPITAL   (Japan)

^d TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

^e SHOWA UNIVERSITY HOSPITAL   (Japan)

^f TOHO UNIVERSITY   (Japan)

^g NIPPON MEDICAL SCHOOL HOSPITAL   (Japan)

^h NIPPON MEDICAL SCHOOL TAMA NAGAYAMA HOSPITAL   (Japan)

ⁱ JICHI MEDICAL UNIVERSITY   (Japan)

^j Shonan Kamakura Joint Reconstruction Center   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE;

ARTICLE; BRADYCARDIA; CLINICAL TRIAL; DOSE RESPONSE; DRUG FORMULATION; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; SPINAL ANESTHESIA;

EID: 0031944062     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Ekblom L, Widman B : LAC-43 and tetracaine in spinal anaesthesia. A controlled clinical study. Acta Anaesthesiol Scand Suppl 23 : 419, 1966
2. Roberts FL, Brown EC, Davis R, et al. : Comparison of hyperbaric and plain bupivacaine with hyperbaric cinchocaine as spinal anaesthetic agents. Anaesthesia 44: 471, 1989
3. Phelan DM, MacEvilly M: A comparison of hyper- and isobaric solutions of bupivacaine for subarachnoid block. Anaesth Intensive Care 12: 101, 1984
4. Greene NM : Distribution of local anesthetic solutions within the subarachnoid space. Anesth Analg 64: 715, 1985
5. Mukkada TA, Bridenbaugh PO, Singh P, et al. : Effects of dose, volume, and concentration of glucose-free bupivacaine in spinal anesthesia. Reg Anesth 11: 98, 1986
6. Bromage PR : Clinical studies of spinal of epidural analgesia, Epidural Analgesia. Philadelphia, Saunders WB Co, 1978, p 144
7. Chambers WA, Littlewood DG, Edstrom HH, et al. : Spinal anaesthesia with hyperbaric bupivacaine, effects of concentration and volume administered. Br J Anaesth 54: 75, 1982
8. Castterall WA, Mackie K : Local anesthetics, Goodman & Gilman's the Pharmacological Basis of Therapeutics. Edited by Hardman JG, et al. New York, McGraw-Hill, 1996, p 331
9. Chambers WA, Edstrom HH, Scott DB : Effect of baricity on spinal anaesthesia with bupivacaine. Br J Anaesth 53: 279, 1981
10. Liu SS, Ware PD, Allen HW, et al.: Dose-response characteristics of spinal bupivacaine in volunteers ; clinical implications for ambulatory anesthesia. Anesthesiology 85: 729, 1996
11. Burm AG, van Kleef JW, Gladines MP, et al. : Plasma concentrations of lidocaine and bupivacaine after subarachnoid administration. Anesthesiology 59: 191, 1983
12. Tarkkila PJ, Kaukinen S : Complications during spinal anesthesia ; a prospective study. Reg Anesth 16: 101, 1991