Apoptosis induced by fast neutrons versus 60Co γ-rays in human peripheral blood lymphocytes

International Journal of Radiation Biology

Volumn 73, Issue 3, 1998, Pages 289-295

  Vral, A ^a   Cornelissen, M ^a   Thierens, H ^b   Louagie, H ^a   Philippe J ^c   Strijckmans, K ^b   De Ridder, L ^a  

^a Section Histology   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60;

APOPTOSIS; ARTICLE; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; FAST NEUTRON RADIATION; GAMMA RADIATION; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL;

ADULT; APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FAST NEUTRONS; GAMMA RAYS; HUMANS; LINEAR ENERGY TRANSFER; LYMPHOCYTES; MIDDLE AGED;

EID: 0031943365     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098142383     Document Type: Article

References (43)

1. BARENDSEN, G. W., 1974, Characteristics of tumour responses to different radiations and the relative biological effectiveness of fast neutrons. European Journal of Cancer, 10, 269-274.
2. BEWLEY, D. K., 1968, Calculated LET distributions of fast neutrons. Radiation Research, 34, 437-445.
3. BILBAO, A., PROSSER, J. S., EDWARDS, A. A., MOODY, J. C. and LLOYD, D. C., 1989, The induction of micronuclei in human lymphocytes by in vitro irradiation with alpha particles from plutonium-239. International Journal of Radiation Biology, 56, 287-292.
4. BLANK, K. R., RUDOLTZ, M. S., KAO, G. D., MUSCHEL, R. J. and MCKENNA, W. G., 1997, Review: the molecular regulation of apoptosis and implications for radiation oncology. International Journal of Radiation Biology, 71, 455-466.
5. CLARKE, A. R., PURDY, C. A., HARRISON, D. J., MORRIS, R. G., BIRD, C. C., HOOPER, M. L. and WYLLIE, A. H., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362, 849-851.
6. EASTMAN, A., 1993, Highlights. Apoptosis: a product of programmed and unprogrammed cell death. Toxicology and Applied Pharmacology, 121, 160-164.
7. FIELD, S. B. and HORNSEY, S., 1979, Neutron RBE for normal tissues. In High LET Radiations in Clinical Radiotherapy, edited by G. W. Barendsen, J. J. Broerse and K. Breur, (Oxford: Pergamon), pp. 181-186.
8. FRITSCH, P., RICHARD-LE NAOUR, H., DENIS, S. and MENETRIER, F., 1994, Kinetics of radiation-induced apoptosis in the cerebellum of 14-day-old rats after acute or during continuous exposure. International Journal of Radiation Biology, 66, 111-117.
9. FUKS, Z., HAIMOVITZ-FRIEDMAN, A. and KOLESNICK, R. N., 1995, The role of the sphingomyelin pathway and protein kinase C in radiation induced cell kill. Important Advances in Oncology, 54, 19-31.
10. FURUNO, I., YADA, T., MATSUDAIRA, H. and MARUYAMA, T., 1979, Induction and repair of DNA strand breaks in cultured mammalian cells following fast neutron irradiation, International Journal of Radiation Biology, 36, 639-648.
11. HAIMOVITZ-FRIEDMAN, A., KAN, C. C., EHLEITER, D., PERSAUD, R. S., MCLOUGHLIN, M., FUKS, Z. and KOLESNICK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Journal of Experimental Medicine, 180, 525-535.
12. HEDGES, M. J. and HORNSEY, S., 1978, The effect of X-rays and neutrons on lymphocyte death and transformation. International Journal of Radiation Biology, 33, 291-300.
13. HENDRY, J. H., POTTEN, C. S. and MERRITT, A., 1995, Apoptosis induced by high-and low-LET radiations. Radiation Environmental Biophysics, 34, 59-62.
14. HERTVELDT, K., PHILIPPE, J., THIERENS, H., CORNELISSEN, M., VRAL, A. and DE RIDDER, L., 1997, Technical Report: Flow cytometry as a quantitative and sensitive method to evaluate low dose radiation induced apoptosis in vitro in human peripheral blood lymphocytes. International Journal of Radiation Biology, 71, 429-433.
15. ICRU, 1970, Report 16, Linear energy transfer. (Washington, DC: International Commission on Radiation Units and Measurements), p. 13.
16. ICRU, 1977, Report 26. Neutron dosimetry for biology and medicine. (Washington, DC: International Commission on Radiation Units and Measurements), p. 52.
17. ICRU, 1979, Report 30. Quantitative concepts and dosimetry in radiobiology. (Washington, DC: International Commission on Radiation Units and Measurements), p. 13-14.
18. LANE, D. P., 1992, p53, guardian of the genome. Nature, 358, 15-16.
19. LEE, J. M. and BERNSTEIN, A., 1993, p53 mutations increase resistance to ionizing radiation. Proceedings of the National Academy of Science, USA, 90, 5742-5746.
20. LING, C. C., CHEN, C. H. and LI, W. X., 1994, Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves. Radiotherapy and Oncology, 32, 129-136.
21. LLOYD, D. C. and EDWARDS, A. A., 1983, Chromosome aberrations in human lymphocytes: effect of radiation quality, dose and dose rate. In Radiation-Induced Chromosome Damage in Man, edited by T. Ishihara and M. S. Sasaki (New York: Liss), pp. 23-49.
22. LONE, M. A., FERGUSON, A. J. and ROBERTSON, B. C., 1981, Characteristics of neutrons from Be targets bombarded with protons, deuterons and alpha particles. Nuclear Instruments and Methods, 189, 515-523.
23. LOWE, S. W., SCHMITT, K. M., SMITH, S. W., OSBORNE, B. A. and JACKS, T., 1993, p53 is required for radiation induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
24. MACKLIS, R. M., BERESFORD, B. A., PALAYOOR, S., SWEENEY, S. and HUMM, J. L., 1993, Cell cycle alterations, apoptosis, and response to low-dose-rate radioimmunotherapy in lymphoma cells. International Journal of Radiation Oncology, Biology, Physics, 27, 643-650.
25. NATARAJAN, A. T. and OBE, G., 1978, Molecular mechanisms involved in the production of chromosomal aberrations; 1. Utilization of Neurospora endonuclease for the study of aberration production in G2 stage of the cell cycle. Mutation Research, 52, 137-149.
26. NATARAJAN, A. T. and OBE, G., 1984, Molecular mechanisms involved in the production of chromosomal aberrations; III. Restriction endonucleases. Chromosoma, 90, 120-127.
27. OJEDA, F., DIEHL, H. A. and FOLCH, H., 1994, Radiation induced membrane changes and programmed cell death: possible interrelationships. Scanning Microscopy, 8, 645-651.
28. 212Bi α-particle irradiation. Nuclear Medicine and Biology, 20, 795-805.
29. 2/M block in murine T-lymphoma cells. Radiation Research, 141, 235-243.
30. RADFORD, I. R. and MURPHY, T. K., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. International Journal of Radiation Biology, 65, 229-239.
31. RAMAKRISHNAN, N., MCLAIN, D. E. and CATRAVAS, G. N., 1993, Membranes as sensitive targets in thymocyte apoptosis. International Journal of Radiation Biology, 63, 693-701.
32. SEKI, H., KANEGANE, H., IWAI, K., KONNO, A., OHTA, K., YACHIF, A., TANIGUCHI, N. and MIYAWAKI, T., 1994, Ionizing radiation induces apoptotic cell death in human TcR-γ/δ + T and natural killer cells without detectable p53 protein. European Journal of Immunology, 24, 2914-2917.
33. SELLINS, K. S. and COHEN, J. J., 1987, Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. The Journal of Immunology, 139, 3199-3206.
34. SPOTHEIM-MAURIZOT, M., CHARLIER, M. and SABATTIKR, R., 1990, DNA radiolysis by fast neutrons. International Journal of Radiation Biology, 57, 301-313.
35. STORY, M. D., VOEHRINGER, D. W., MALONE, C. G., HOBBS, M. L. and MEYN, R. E., 1994, Radiation-induced apoptosis in sensitive and resistant cells isolated from a mouse lymphoma. International Journal of Radiation Biology, 66, 659-668.
36. STRASSER, A., HARRIS, A. W., JACKS, T. and CORY, S., 1994, DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhabitable by Bcl-2. Cell, 79, 329-339.
37. SZUMIEL, I., 1994, Review: ionizing radiation-induced cell death. International Journal of Radiation Biology, 66, 329-341.
38. VAUGHAN, A. T. M., GORDON, D. J., CHETTLE, D. R. and GREEN, S., 1991, Neutron and Cobalt-60 γ irradiation produce similar changes in DNA supercoiling. Radiation Research, 127, 19-23.
39. VRAL, A., THIERENS, H. and DE RIDDER, L., 1992, Study of dose-rate and split-dose effects on the in vitro micronucieus yield in human lymphocytes exposed to X-rays. International Journal of Radiation Biology, 61, 777-784.
40. 60CO γ-rays in human peripheral blood lymphocytes. International Journal of Radiation Biology, 65, 321-328.
41. YAMADA, T. and OHYAMA, H., 1988, Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis). International Journal of Radiation Biology, 53, 65-75.
42. WARENIUS, H. M. and DOWN, J. D., 1995, RBE of fast neutrons for apoptosis in mouse thymocytes. International Journal of Radiation Biology, 68, 625-629.
43. WYLLIE, A. H., 1981, Cell death: a new classification separating apoptosis from necrosis. In Cell Death in Biology and Pathology, edited by I. D. Bowen and R. A. Lockshin (London: Chapman & Hall), pp. 9-34.