Induction of in vitro heart block is not restricted to affinity purified anti-52 kDa Ro/SSA antibody from mothers of children with neonatal lupus

Lupus

Volumn 7, Issue 3, 1998, Pages 141-147

  Viana, V S Trinadade ^a   Garcia, S ^b   Nascimento, Jhm ^b   Elkon, K B ^c   Brot, N ^d   De Campos Carvalho, A C ^b   Bonfa E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Department of Obstetrics Gynecology

^d INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

Author keywords

Autoantibodies; Autoimmunity; Congenital heart block; Neonatal lupus erythematosus; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN ANTIBODY;

ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ATRIOVENTRICULAR BLOCK; CLINICAL ARTICLE; CONGENITAL HEART BLOCK; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; ISOLATED HEART; LUPUS ERYTHEMATOSUS; MOLECULAR WEIGHT; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0031943156     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/096120398678919895     Document Type: Article

References (29)

1. Scott JP et al. Connective tissue disease, antibodies to ribonueleoprotein, and congenital heart block. N Engl J Med 1983; 309: 209-212
2. Reed BR et al. Autoantibodies to SSA/Ro in infants with congenital heart block. J Pediatr 1983, 103: 889-891.
3. Buyon JP, Winchester R. Congenital complete heart block: a model of passively autoimmune injury. Arthritis Rheum 1990, 33: 609-614.
4. Buyon JP et al. Acquired congenital heart block: pattern of maternal antibody response J Clin Invest 1989; 84: 627-634
5. Silverman E, Mamula M, Hardin JA, Laxer R. Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus. J Rheumatol 1991; 18: 120-124.
6. Reichlin M et al Concentration of autoantibodies to native 60 kd Ro/ SSA and 52 kd Ro/SSA in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum 1994; 37. 1698-1703.
7. Alexander EL, Buyon JP, Provost TT, Guamieri T. Anti-Ro/SSa antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. Arthritis Rheum 1992; 35: 176-189.
8. Garcia S et al. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SS-A positive patients in rabbits hearts. J Clin Invest 1994; 93: 718-724.
9. Harley JB et al. Ro (SS-A) antibody and antigen in patient with congenital complete heart block. Arthritis Rheum 1985, 28: 1321-1325.
10. Lockshin MD, Bonfa E, Elkon KB, Druzin ML Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus. Arthritis Rheum 1988, 31 697-701
11. Lima F et al. Obstetric outcome in systemic lupus erythematosus. Semin Arthritis Rheum 1995; 25: 184-192.
12. Venables PJ, Smith PR, Maini RN Purification and characterization of the Sjögren's syndrome A and B antigens. Clin Exp Immunol 1983, 54 731-783
13. Wolin SL, Steitz JA The Ro small cytoplasmsc ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 1984; 81. 1996-2000.
14. Yamagata H, Harley JB, Reichlin M. Molecular properties of the Ro/ SS-A antigen and enzyme-linked immunosorbent assay for quantitation of antibody J Clin Invest 1984; 74: 625-633.
15. Ben-Chetrit E, Chan EK, Sullivan KF, Tan EM. A 52kD protein is a novel component of the SS-A/Ro antigenic particle. J Exp Med 1988; 167: 1560-1571
16. Buyon JP et al. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in children. Comparison of enzyme-linked immunosorbent assay and immunoblot for measurement anti-SS-A/Ro and anti-SS-B/La antibodies Arthritis Rheum 1993; 36: 1263-1273.
17. Meilof JF et al. Maternal autoamibodies and congenital heart block: no evidence for the existence of a unique heart block-associated anti-Ro/ SS-A autoantibody profile. Lupus 1993; 2: 239-246.
18. Julkunen H et al. Isolated congenital heart block, long-term outcome of mothers and characterization of the immune response to SS A/Ro and SS B/La. Arthritis Rheum 1993; 36: 1588-1598.
19. Dörner T et al Significant increased maternal and fetal autoantibody levels to 52kDa Ro(SSA) and La(SSB) in complete congenital heart block. Lupus 1995, 4. 27 (abstract).
20. Silverman ED et al. Autoantibodies of neonatal lupus erythematosus. J Invest Dermatol 1995; 100: 499-505.
21. Viana VST et al. Affinity purified anti-52 kD Ro/SSA antibody induces A-V heart block in vitro. Arthritis Rheum 1995, 38: S306 (abstract 920).
22. Boutjdir M et al Arrythmogenicity of IgG and anti-52 kDa SSA/Ro affinity-purified antibodies from mothers of children with congenital heart block. Circ Res 1997; 80. 354-362.
23. Tan EM et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277.
24. Kurata N. Tan EM. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis. Arthritis Rheum 1976; 19: 574-580
25. Manley G et al. Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuropathy recognize the Ro-52 kDa antigen. J Neuro-Oncol 1994; 19: 105-112.
26. Adam SA et al. mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol 1986; 6: 2932-2943
27. Taylor PV et al. Maternal antibodies against fetal cardiac antigens in congenital complete heart block N Engl J Med 1986; 315: 667-672.
28. Mamula MJ, Fox OF, Yamagata H, Harley JB The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG. J Exp Med 1989, 86: 1889-1901.
29. Itoh Y, Igarashi T, Fukunaga Y, Yamamoto M. Stress-induced cell surface expression and antigemc alteration of the Ro/SS-A autoantigen. Arthritis Rheum 1995; 38: 279 (abstract 756).