Lack of autonomic contributions to tonic nitric oxide-mediated vasodilatation in unanesthetized free-moving rats

Journal of Hypertension

Volumn 16, Issue 1, 1998, Pages 55-61

  Radaelli, Alberto ^b   Mircoli, Luca ^b   Perlini, Stefano ^b   Bolla, Gianni ^b   Mori, Ileana ^b   Mancia, Giuseppe ^b   Ferrari, Alberto U ^a  

^a Ctro Fisiol Clinica e Ipertensione   (Italy)

^b NONE

Author keywords

Blood pressure; Ganglionic blockade; L nitromonomethyl L arginine; Nitric oxide; Sino aortic denervation; Sympathectomy; Unanesthetized rat

Indexed keywords

ADRENALIN; CATECHOLAMINE DERIVATIVE; HEXAMETHONIUM; N(G) METHYLARGININE; NITRIC OXIDE; NORADRENALIN; OXIDOPAMINE;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; CHEMICAL SYMPATHECTOMY; CONTROLLED STUDY; DENERVATION; GANGLION BLOCK; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEAN ARTERIAL PRESSURE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRESSOR RESPONSE; PRESSORECEPTOR; PRIORITY JOURNAL; PULSE RATE; RAT; SYMPATHECTOMY; VASODILATATION;

EID: 0031942682     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816010-00010     Document Type: Article

References (34)

1. Furchgott RF, Zawadzi JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288:373-376.
2. Gardiner SM, Compton AM, Kempt PA, Bennett T. Regional and cardiac haemodynamic responses to glyceryl trinitrate, acetylcholine. bradykinin and endothelin-1 in conscious rats: effects of W-nitro-L-arginine methyl ester. Br J Pharmacol 1990; 101:632-639.
3. Luscher TF, Vanhoutte PM. The endothelium: modulation of cardiovascular function. Boca Raton, FL: CRC Press; 1990. pp. 23-41.
4. Palmer RMJ. Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333:664-666.
5. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 1992; 20:298-303.
6. Conrad KP, Whittemore SL. W-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats. Am J Physiol 1992; 262:R1137-R1144.
7. Lacolley PJ, Lewis SJ, Brody MJ. Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats. Hypertension 1991; 17:881-887.
8. Minami N, Imai Y, Hashimoto J. Abe K. Contribution of vascular nitric oxide to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats. Clin Sci 1995; 89:177-182.
9. Pegoraro AA, Carretero OA, Sigmon DH, Beierwaltes WH. Sympathetic modulation of endothelium-denved relaxing factor. Hypertension 1992; 19:643-647.
10. Sato M, Sakuma I. Kobayashi T. Togashi H. Yoshioka M, Saito H, et al. Centrally formed nitric oxide decreases sympathetic activity, while sympathetic activity stimulates peripheral nitric oxide production [abstract], Circulation 1991; 84:A2593.
11. Toda N, Kitamura Y, Okamura T. Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs. Hypertension 1993; 21:3-8.
12. Zambetis M, Dusting GJ, Rajanayagam S. Woodman OL. Mechanism of the hypertension produced by inhibition of nitric oxide biosynthesis in rats. J Cardiovasc Pharmacol 1991; 17 (suppl 3):S191-S197.
13. Zhang ZQ, Barrès C, Julien C. Nitric oxide synthesis and the control of blood pressure in sympathectomized rats. Genetic Hypertens 1992; 218:27-29.
14. Komer PI, Langsford G, Starr D, Uther JB, Ward W, White W. The effects of chloralose-urethane anesthesia on the local and autonomic components of the circulatory response to arterial hypoxia. J Physiol 1968; 199:283-302.
15. Mancia G, Mark AL. Arterial baroreflexes in humans. In: Handbook of physiology. The cardiovascular system III. Bethesda, MD: American Physiological Society. 1983. pp. 755-793.
16. Wang Y-X, Zhou T, Chua TC, Pang CCY. Effects of inhalation and intravenous anesthetic agents on pressor response to N-nitro-L-arginine. Eur J Pharmacol 1991; 198:183-188.
17. Krieger EM. Neurogenic hypertension in the rat. Circ Res 1964; 15:511-521.
18. Aviado DM. Hemodynamic effects of ganglion blocking drugs. Circ Res 1960; 8:304-314.
19. Sander M, Hansen PG, Victor RG. Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide. Hypertension 1995; 26:691-695.
20. Hjemdahl P. Catecholamine measurements by high performance liquid chromatography. Am J Physiol 1984; 247:E13-E20.
21. Rand MJ, Li CG. Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Annu Rev Physiol 1995; 57:659-682.
22. Toda N. Non adrenergic non cholinergic innervation in monkeys and human cerebral arteries. Br J Pharmacol 1981; 72:281-283.
23. Vanhoutte PM, Miller VM. Alpha 2 adrenoceptors and endothelium-derived relaxing factor. Am J Med 1989; 87 (suppl 3C):1S-5S.
24. Yoshida K, Okamura T, Kimura H, Bredt DS, Snyder SH, Toda N. Nitric oxide synthase-immureactive fibers in dog cerebral and peripheral arteries. Brain Res 1993; 629:67-72.
25. La Montagne D, Pohl U, Busse R. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res 1992; 70:123-130.
26. Rubany GM, Romero JC, Vanhoutte PM. Flow induced release of endothelium-derived relaxing factor. Am J Physiol 1986, 250:H1145-H1149.
27. Kanai AJ, Strauss HC, Trusky GA, Crews AL, Grunfeld S, Malinski T. Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a prophyrinic microsensor. Circ Res 1995; 74:284-293.
28. Zeballos GA, Bernstein RD, Thompson CI, Forfia PR, Seyedi N, Shen W, et al. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 1995; 91:2982-2988.
29. Gardiner SM, Compton AM, Kemp PA, Bennett T. Regional and cardiac haemodynamic responses to glyceryl trinitrate, acetylcholine, bradykinin and endothelin-1 in conscious rats: effects of N-nitro-L-arginine methyl ester. Br J Pharmcol 1990; 101:632-639.
30. Widdop RE, Gardiner SM, Kemp PA, Bennett T. The influence of atropine and atenolol on the cardiac haemodynamic effects of N-nitro-L-arginine methyl ester in conscious, Long Evans rats. Br J Pharmacol 1992; 105:653-656.
31. Weyrich A. Ma X-L, Buerke M, Murohara T, Armstead VE, Lefer AM, et al. Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circ Res 1994; 75:692-700.
32. Sadoff JD, Scholz PM, Weiss HR. Endogenous basal nitric oxide production does not control myocardial oxygen consumption or function. Proc Soc Exp Biol Med 1996; 211:332-338.
33. Hansen J, Jacobsen TN, Victor RG. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans? Hypertension 1994; 24:439-444.
34. Pabla R, Curtis MJ. Effects of NO modulation on cardiac arrhythmias in the rat isolated heart. Circ Res 1995; 77:984-992.