Discovery and structure - Activity relationship studies of a novel and specific peptide motif, pro-X-X-X-Asp-X, as a platelet fibrinogen receptor antagonist

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 3, 1998, Pages 355-364

  Hayashi, Yoshio ^a   Katada, Jun ^a   Sato, Yoshimi ^a   Igarashi, Katsuhide ^a   Takiguchi, Yoshimi ^a   Harada, Takeo ^a   Muramatsu, Michiko ^a   Yasuda, Emiko ^a   Uno, Isao ^a  

^a NIPPON STEEL CORPORATION   (Japan)

Author keywords

Anti platelet agent; Fibrinogen receptor antagonist; Integrins; Peptide motif; RGD peptide

Indexed keywords

ALANINE; AMINO ACID; ANTITHROMBOCYTIC AGENT; ARGINYLGLYCYLASPARTIC ACID; COLLAGEN; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCINE; HEXAPEPTIDE; INTEGRIN; PROLINE; SERINE;

AMINO ACID SEQUENCE; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; HUMAN; HUMAN CELL; PEPTIDE SYNTHESIS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

AMINO ACID SEQUENCE; BLOOD PLATELETS; FIBRINOLYTIC AGENTS; HUMANS; INTEGRINS; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ILIA;

EID: 0031942604     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10050-5     Document Type: Article

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