Effect of serine proteinase inhibitors on neutrophil function: α-1- proteinase inhibitor, antichymotrypsin, and a recombinant hybrid mutant of antichymotrypsin (LEX032) modulate neutrophil adhesion interactions

Journal of Leukocyte Biology

Volumn 63, Issue 1, 1998, Pages 75-82

  Carney, David F ^a   Jagels, Mark A ^a   Hugli, Tony E ^a   Sands, Howard ^b   Rubin, Harvey ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Lexin Pharmaceutical Corporation   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CD43; Fibronectin; Serpins

Indexed keywords

ALPHA 1 ANTITRYPSIN; BETA1 INTEGRIN; CD18 ANTIGEN; CHYMOTRYPSIN INHIBITOR; ELASTASE; FIBRONECTIN; HYBRID PROTEIN; L SELECTIN; LEUKOSIALIN; LEX 032; SCLEROPROTEIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 0031942535     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.63.1.75     Document Type: Article

References (20)

1. Travis, J., Salvesen, G. S. (1983) Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709.
2. Potempa, J., Korzus, E., Travis, J. (1991) The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J. Biol. Chem. 269, 15957-15960.
3. 1-antichymotrypsin at 2.7 Å resolution and its comparison with other serpins. J. Mol. Biol. 218, 595-606.
4. 1-proteinase inhibitor: Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function. J. Mol. Biol. 177, 531-556.
5. Doring, G. (1994) The role of neutrophil elastase in chronic inflammation. Am. J. Respir. Crit. Care Med. 150, S114-S117.
6. Travis, J., Fritz, H. (1991) Potential problems in designing elastase inhibitors for therapy. Am. Rev. Respir. Dis. 143, 1412-1415.
7. 1-antichymotrypsin is an inhibitor of pancreatic elastases. Eur. J. Biochem. 151, 327-331.
8. 1-antichymotrypsin. Biochem. J. 245, 699-704.
9. 1-antichymotrypsin into a human neutrophil elastase inhibitor: Demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities. Biochemistry 33, 7627-7633.
10. Wei, A., Rubin, H., Cooperman, B. S., Christianson, D. W. (1994) Crystal stucture of an uncleaved serpin reveals the conformation of an inhibitory reactive loop. Nature Struct. Biol. 1, 251-257.
11. Murohara, T., Guo, J., Lefer, A. M. (1995) Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury. J. Pharmacol. Exp. Ther. 274, 1246-1253.
12. Scalia, R., Gauthier, T. W., Lefer, A. M. (1995) Beneficial effects of LEX032, a novel recombinant serine protease inhibitor, in murine traumatic shock. Shock 4, 251-256.
13. Hook, J., Weinbauin, G., Oppenheim, D., Bai, C., Deren, J. J., Rubin, H., Sands, H. (1995) Novel modified recombinant human alpha-1 antichymotrypsin (LEX032) inhibits inflammation as determined by neutrophil recruitment in vivo. FASEB J. 9, A965 (abstract).
14. 1-antitrypsin. FEBS Lett. 300, 21-24.
15. Kilpatrick, L., Johnson, J. L., Nickbarg, E. B., Wang, Z., Clifford, T. F., Banach, M., Cooperman, B. S., Douglas, S. D., Rubin, H. (1991) Inhibition of human neutrophil superoxide generation by α1-antichymotrypsin. J. Immunol. 146, 2388-2393.
16. 2-acetyltransferase activity and inhibition by antiproteinase. Eur. J. Biochem. 182, 661-666.
17. Camussi, G., Tetta, C., Bussolino, F., Baglioni, C. (1988) Synthesis and release of platelet-activating factor is inhibited by plasma α1-proteinase inhibitor or α1-antichymotrypsin and is stimulated by proteinases. J. Exp. Med. 168, 1293-1306.
18. Lomas, D. A., Stone, S. R., Llewellyn-Jones, C., Keogan, M.-T., Wang, Z., Rubin, H., Carrell, R. W., Stockley, R. A. (1995) The control of neutrophil chemotaxis by inhibitors of cathepsin G and chymotrypsin. J. Biol. Chem. 270, 23437-23443.
19. Kishimoto, T. K., Jutila, M. A., Butcher, E. C. (1990) Identification of a human peripheral lymph node homing receptor: a rapidly down-regulating adhesion molecule. Proc. Natl. Acad. Sci. USA 87, 2244-2248.
20. Wright, S. D., Rao, P. E., VanVorhis, W. C., Crigmyle, L. S., Lida, K., Talle, M. A., Westberg, E. F., Goldstein, G., Silverstein, S. C. (1983) Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80, 5699-5703.