Mechanism of action of honey bee (Apis mellifera L.) venom on different types of muscles

Human and Experimental Toxicology

Volumn 17, Issue 3, 1998, Pages 185-190

  Nabil, Zohour I ^a   Hussein, Aida A ^a   Zalat, Samy M ^a   Rakha, Miran Kh ^a  

^a Suez Canal University   (Egypt)

Author keywords

ECG; Honey bee venom; Muscles

Indexed keywords

ATROPINE; BEE VENOM; GALLAMINE TRIETHIODIDE; NICOTINE; NICOTINIC RECEPTOR; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BRADYCARDIA; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DUODENUM; ELECTROCARDIOGRAM; FROG; GASTROCNEMIUS MUSCLE; HEART MUSCLE; HEART PERFUSION; HEART RATE; INOTROPISM; MALE; MEMBRANE STABILIZATION; MUSCLE FIBER MEMBRANE; MUSCLE FUNCTION; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; R WAVE; RABBIT; RECEPTOR BLOCKING; SCIATIC NERVE; SINUS ARRHYTHMIA; SKELETAL MUSCLE; SMOOTH MUSCLE; ST SEGMENT; TOAD; TOXIN ANALYSIS;

ANIMALS; ATROPINE; BEE VENOMS; BUFONIDAE; CALCIUM CHANNEL BLOCKERS; ELECTROCARDIOGRAPHY; HEART; HEART CONDUCTION SYSTEM; HEART RATE; MALE; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH; MYOCARDIAL CONTRACTION; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RABBITS; VERAPAMIL;

ANIMALIA; ANURA; APIS MELLIFERA; APOIDEA; ORYCTOLAGUS CUNICULUS;

EID: 0031942305     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032798678908396     Document Type: Article

References (21)

1. Langer J. Ueber das Gift un serer Monig biene. Arch Exp Path Pharmak 1897; 38: 381-396.
2. Neumann W, Habermann E. Beritrage zur karakterisier-ung der wirkstoffe de bien engiftes. Arch Exp Path Pharmak 1954; 222: 367.
3. Anthony T. Tu. Venoms of Bees, Hornets and Wasps In Venoms: Chemistry and Molecular Biology 1977; pp 502-515. A Wilet Interscience Publ. London.
4. Schmidt JO. Biochemistry of insect venoms. Ann Rev Ent 1982; 27: 339-368.
5. Meier J, White J. Handbook of clinical Toxicology of animal Venoms and Poisons. 1995; C.R. Press. New York.
6. Habermann E. Chemistry, pharmacology and toxicology of bee, wasp and hornet venoms. In: Venomous Animals and their venoms 1971; 3: pp 61-93 Bucherl, W and Buckley EE. (Eds), Academic Press, London.
7. Banks BEC, Shipolini AA. Chemistry and pharmacology of honey bee venom. In: Venoms of Hymenoptera 1986; Piek, T. (Ed.) London, Academic press, pp 329-416.
8. Shumacher MJ et al. Biochemical bioavailability of venoms from individual European and Africanized honey bees (Apis mellifera). J Allerg Clin Immun 1992; 90: 59-65.
9. Beard RL. Insect toxins and venoms. Ann Rev Entomol 1963; 8: 1-18.
10. Schmidt JO. Toxinology of venoms from the honey bee, Genus Apis. Toxicon 1995; 33: 917-927.
11. 2 on the cardiovascular system of the rat. Toxicon 1980; 18: 427-435.
12. Hawgood BJ, Smith ChI, Strong PN. Early induction by crotoxin of biphasic frequency changes and giant miniature end plate potentials in frog muscle. Br J Pharmacol 1988; 94: 765-772.
13. Krylov VN. Effect of bee venom on the heart. Mater Povolzhhonf Fiziol Uchastienn Biokhim, Farmakol Morfol, 1973; 1: 86.
14. Vick JA, Brooks BR Jr. Pharmacological studies of the major fractions of bee venoms. A Bee J 1972; 112: 288.
15. Vick JA et al. Beta adrenergic and anti-arrhythmic effects of cardiopep, a newly isolated substance from whole bee venom. Toxicon 1974; 12: 139-144.
16. Kaplinsky E et al. Effects of bees (APIS MELLIFERA) venom on the electrocardiogram and blood pressure. Toxicon 1977; 15: 251-256.
17. Schmidt JO. Chemistry, pharmacology and chemical ecology of ant venoms. In: Venoms of the Hymenoptera 1986; Piek T, (Ed). Academic Press, London, pp 425-508.
18. Snedecor GW, Cochran WG. Statistical methods 1980; 7th ed. Iowa State Univ. Press. Ames, Iowa USA.
19. Mehendale HM. Application of isolated organ techniques in toxicology. In: Principles and methods of Toxicology 1984; Hayes AW. (ed). Raven Press, New York.
20. Korneva NV. Mechanism of change of blood pressure and frequency of heart beat caused by bee venom. Uch Zap Gor K Gos Univ 1972; 56.
21. Ownby CL et al. Melittin and phospholipase A-2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo. Toxicon 1997; 35: 67-80.