The use of heparinase to neutralize residual heparin in blood samples drawn through pediatric indwelling central venous catheters

Journal of Pediatrics

Volumn 132, Issue 1, 1998, Pages 165-167

  Keller, E G ^a   DeFazio, J ^a   Jencks, F ^a   Steiner, M ^a   Rogers, J ^a   Ritchey, A K ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; HEPARIN LYASE;

ADOLESCENT; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; CENTRAL VENOUS CATHETER; CHILD; CLINICAL ARTICLE; CONTAMINATION; CONTROLLED STUDY; HEMOSTASIS; HEPARINIZATION; HUMAN; HUMAN TISSUE; INDWELLING CATHETER; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME;

EID: 0031941919     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3476(98)70506-2     Document Type: Article

References (12)

1. CJ. Bark Coagulation nondisease [letter] N Engl J Med 282 1970 1214
2. GB. Merenstein Heparinized catheters and coagulation studies J Pediatr 79 1971 117 119
3. RJ Linhardt A Grant CL Cooney R. Langer Differential anticoagulant activity of heparin fragments prepared using microbial heparinase J Biol Chem 257 1982 7310 7313
4. DJ Mayo EP Dimond W Kramer MK. Horne Discard volumes necessary for clinically useful coagulation studies from heparinized Hickman catheters Oncol Nurs Forum 23 1996 671 675
5. EE. Czepek latrogenic prolonged aPTT: a nondisease state [editorial] JAMA 227 1974 1304
6. AM Cumming GR Jones RT Wensley RB. Cundall In vitro neutralization of heparin in plasma prior to the activated partial thromboplastin time test: an assessment of four heparin antagonists and two anion exchange resins Thromb Res 41 1986 43 56
7. Ellis R. Coagulapathy screening in children with heparinized central venous catheters. Pediatrics 193:91:1147-50.
8. B Wenz ER. Burns Rapid removal of heparin from plasma by affinity filtration Am J Clin Pathol 96 1991 385 390
9. RS Newman AR. Fagin Heparin contamination in coagulation testing and a protocol to avoid it and the risk of inappropriate FFP transfusion Am J Clin Pathol 104 1995 447 449
10. GJ Despotis AL Summerfield JH Joist In vitro reversal of heparin effect with heparinase: evaluation with whole blood prothrombin time and activated partial thromboplastin time in cardiac surgical patients Anesth Analg 79 1994 670 674
11. RF Baugh KA Deemar JJ. Zimmermann Heparinase in the activated clotting time assay: monitoring heparin-independent alterations in coagulation function Anesth Analg 74 1992 201 205
12. ED Hutt HS. Kindon Use of heparinase to eliminate heparin inhibition in routine coagulation assays J Lab Clin Med 79 1972 1027 1034