Diverse patterns of unresponsiveness in an acetylcholine receptor- specific T-cell clone from a myasthenia gravis patient after engaging the T- cell receptor with three different ligands

Journal of Neuroimmunology

Volumn 82, Issue 2, 1998, Pages 182-190

  Bond, Alison P ^a   Corlett, Louise ^a   Curnow, S John ^a   Spack, Edward ^b   Willcox, Nick ^a   Newsom Davis, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Anergy; Apoptosis; Immunotherapy; Myasthenia gravis; T lymphocytes

Indexed keywords

CHOLINERGIC RECEPTOR; HLA DR4 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL CLONE; CELL LOSS; CLONAL ANERGY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MYASTHENIA GRAVIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL SURVIVAL; CLONE CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERLEUKIN-2; KINETICS; LIGANDS; MYASTHENIA GRAVIS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CHOLINERGIC; T-LYMPHOCYTES; TIME FACTORS;

EID: 0031940941     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00202-6     Document Type: Article

References (36)

1. Beeson D., Brydson M., Wood A., Vincent A., Newsom-Davis J. Primary structure of the human muscle acetylcholine receptor: Cloning and expression in Escherichia coli of cDNA for the α-subunit. Biochem. Soc. Trans. 17:1988;219-220.
2. Beeson D., Brydson M., Betty M., Jeremiah S., Povey S., Vincent A., Newsom-Davis J. Primary structure of the human muscle acetylcholine receptor: cDNA cloning of the γ and ε subunits. Eur. J. Biochem. 215:1993;229-238.
3. Critchfield J.M., Racke M.K., Zuniga-Pflucker J.C., Cannella B., Raine C.S., Goverman J., Lenardo M.J. T-cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 263:1994;1139-1143.
4. Gilhus N., Willcox N., Harcourt G., Nagvekar N., Beeson D., Vincent A., Newsom-Davis J. Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T-cells. J. Neuroimmunol. 56:1995;65-76.
5. Gimmi C.D., Freeman G.J., Gribben J.G., Gray G., Nadler L.M. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA. 90:1993;6586-6590.
6. Harding F.A., McArthur J.G., Gross J.A., Raulet D.H., Allison J.P. CD28 mediated signalling costimulates murine T-cells and prevents induction of anergy in T-cell clones. Nature. 356:1992;607-609.
7. Hawke S., Matsuo H., Nicolle M., Malcherek G., Melms A., Willcox N. Autoimmune T-cells in myasthenia gravis: Heterogeneity and potential for specific immunotargetting. Immunol. Today. 17:1996;307-311.
8. Hohlfeld R., Toyka K.V. Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes. J. Neuroimmunol. 9:1985;193-204.
9. Ibrahim M.A., Coode W.K., Takei F., Ellis J.S., Chain B.M., Katz D.R. Chemically modified antigen presenting cells induce T-cell allospecific hyporesponsiveness. J. Immunol. 147:1991;4086-4093.
10. Jenkins M.K., Schwartz R.H. Antigen presentation by chemically modified splenocytes induce antigen specific T-cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:1987;302-319.
11. Jenkins M.K., Pardoll D.M., Mizuguchi J., Chused T.M., Schwartz R.H. Molecular events in the induction of a nonresponsive state in interleukin-2 producer T-lymphocyte clones. Proc. Natl. Acad. Sci. USA. 84:1987;5409-5413.
12. Jenkins M.K., Chen C., Jung D.L., Mueller D.L., Schwartz R.H. Inhibition of antigen specific proliferation of type 1 murine T-cell clones after stimulation with immobilised anti-CD3 monoclonal antibodies. J. Immunol. 144:1990;16-22.
13. Jenkins M.K. The role of cell division in the induction of clonal anergy. Immunol. Today. 13:1992;69-73.
14. Kang S., Beverly B., Tran A., Brorson K., Schwartz R.H., Lenardo M.J. Transactivation by AP-1 is a molecular target of T-cell clonal anergy. Science. 257:1992;1134-1138.
15. Kubo T.M., Noda T., Takai T., Tanabe T., Kayano S., Shimizu K., Tanaka H., Takahashi T., Hirose S., Inayama R., Kikuno T., Miyata T., Numa S. Primary structure of δ subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence. Eur. J. Biochem. 149:1985;5-13.
16. Lamb J.R., Skidmore B.J., Green N., Chiller J.M., Feldmann M. Induction of tolerance in influenza virus-immune T-lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1983;1434-1447.
17. Lindstrom J., Shelton D., Fuji Y. Myasthenia gravis. Adv. Immunol. 42:1988;233-284.
18. Matsui K., Boniface J.J., Reay P.A., Schild H., Fazekas De St Groth B., Davis M.M. Low affinity interactions of peptide-MHC complexes with T-cell receptors. Science. 254:1991;1788-1791.
19. Matsuo H., Batocchi A., Hawke S., Nicolle M., Jacobson L., Vincent A., Newsom-Davis J., Willcox N. Peptide-selected T-cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor. J. Immunol. 155:1995;3683-3692.
20. Nag B., Deshpande S.V., Clark B.R. Novel methods to rapidly and sensitively analyze antigenic peptide binding to MHC class II molecules. J. Immunol. Methods. 142:1991;105-111.
21. Nag B., Passmore D., Deshpande S.V., Clark B.R. In vitro maximum binding of antigenic peptides to murine MHC class II molecules does not always take place at the acidic pH of the in vivo endosomal compartment. J. Immunol. 148:1992;369-372.
22. Nag B., Wada H.G., Deshpande S.V., Passmore D., Kendrick T., Sharma S.D., Clark B.R., McConnell H.M. Stimulation of T-cells by antigenic peptide complexed with isolated chains of major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA. 90:1993;1604-1608.
23. Nau G.J., Moldwin R.L., Lancki D.W., Kim D., Fitch F.W. Inhibition of IL-2 driven proliferation of murine T-lymphocyte clones by supraoptimal levels of immobilised anti-T-cell receptor monoclonal antibodies. J. Immunol. 139:1987;114-122.
24. Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139:1991;271-279.
25. + lymphocytes by soluble major histocompatibility complex class II-peptide complexes. J. Clin. Invest. 93:1994;1361-1369.
26. Ong B., Willcox N., Wordsworth P., Beeson D., Vincent A., Altmann D., Lanchbury J.S.S., Harcourt G.C., Bell J.I., Newsom-Davis J. Critical role for the Val/Gly86 HLA-DRβ dimorphism in autoantigen presentation to human T-cells. Proc. Natl. Acad. Sci. USA. 88:1991;7343-7347.
27. Quill H., Schwartz R.H. Stimulation of normal inducer T-cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of a long lived state of proliferative nonresponsiveness. J. Immunol. 138:1987;3704-3712.
28. Sansom D.M., Hall N.D. B7/BB1, the ligand for CD28 is expressed on repeatedly activated human T-cells in vitro. Eur. J. Immunol. 23:1993;295-298.
29. Schwartz R.H. A cell culture model for T-lymphocyte clonal anergy. Science. 248:1990;1349-1356.
30. Sharma S.D., Nag B., Su X., Green D., Spack E., Clark B.R., Sriram S. Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatability complex-peptide complexes. Proc. Natl. Acad. Sci. USA. 88:1991;11465-11469.
31. Spack E.G., McCutcheon M.M., Corbelletta N., Nag B., Passmore D., Sharma S. Induction of tolerance in experimental autoimmune myasthenia gravis with solubilized MHC class II:acetylcholine receptor peptide complexes. J. Autoimmun. 8:1995;787-807.
32. Spack E.G. Drugs in development for the treatment of multiple sclerosis: Antigen-specific therapies. Exp. Opin. Invest. Drugs. 5:1996;1331-1348.
33. Tan P., Anasettie C., Hansen J.A., Melrose J., Brunvand J., Ledbetter J.A., Linsley P.S. Induction of alloantigen specific hyporesponsiveness in human T-lymphocytes by blocking the interaction of CD28 and its natural ligand B7/BB1. J. Exp. Med. 177:1993;165-173.
34. Truffault F., Cohen-Kaminsky S., Khall I., Levasseur P., Berrih-Aknin S. Altered intrathymic T-cell repertoire in human myasthenia gravis. Ann. Neurol. 41:1997;731-741.
35. Valitutti S., Müller S., Cella M., Padovan E., Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature. 375:1995;148-151.
36. Viola A., Lanzavecchia A. T-cell activation determined by T-cell receptor number and tunable thresholds. Science. 273:1996;104-106.