Management of resistant gestational trophoblastic tumors

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 43, Issue 2, 1998, Pages 111-118

  Newlands, Edward S ^a   Bower, Mark ^b   Holden, Lydia ^b   Short, Delia ^b   Seckl, Michael J ^b   Rustin, Gordon J S ^b   Begent, Richard H J ^b   Bagshawe, Kenneth D ^b  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Chemotherapy; Trophoblastic tumor

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; ETOPOSIDE; FOLINIC ACID; METHOTREXATE; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER METASTASIS; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROGNOSIS; STOMACH ADENOCARCINOMA; SURVIVAL RATE; TREATMENT FAILURE; TROPHOBLASTIC TUMOR; UTERINE CERVIX TUMOR;

ADULT; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FEMALE; HUMANS; LEUCOVORIN; METHOTREXATE; PREGNANCY; RISK FACTORS; TREATMENT OUTCOME; TROPHOBLASTIC NEOPLASMS; UTERINE NEOPLASMS; VINCRISTINE;

EID: 0031940552     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Bagshawe KD: Risk and prognostic factors in trophoblastic neoplasia. Cancer 1976;38:1373-1385
2. World Health Organization Scientific Group of Gestational Trophoblastic Diseases: Gestational Trophoblastic Diseases. Geneva, WHO, 1983
3. Newlands ES, Bagshawe KD, Begent RHJ, et al: Results with the EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) regime in high risk gestational trophoblastic tumours, 1979-1989. Br J Obstet Gynaecol 1991;98:550-557
4. Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481
5. Peto R, Pike M, Armitage P, et al: Design and analysis of randomised clinical trials requiring a prolonged observation of each patient: II. Analysis and examples. Br J Cancer 1977;35: 1-39
6. Cox D: Regresion models and life tables. J Royal Stat Soc B 1972;34:187-220
7. Bower M, Newlands ES, Holden L, et al: EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) for high risk gestational trophoblastic tumours: Results from a cohort of 272 patients. J Clin Oncol 1997; 15:2636-2643
8. Begent RHJ, Bagshawe KD, Green AJ, et al: The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma. Br J Cancer 1987;55:657-660
9. Findlay M, Young H, Cunningham D, et al: Noninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: Correlation with tumor response to fluorouracil. J Clin Oncol 1996;14:700-708
10. Rustin GJS, Newlands ES, Lutz J-M, et al: Combination but not single agent methotrexate chemotherapy for gestational trophoblastic tumours (GTT) increases the incidence of second tumours. J Clin Oncol 1996;14:2769-2773
11. Lotz J-P, Andre T, Donsimoni, et al: High dose chemotherapy with ifosfamide, carboplatin and etoposide combined with autologous bone marrow transplantation for the treatment of poor-prognosis germ cell tumors and metastatic trophoblastic disease in adults. Cancer 1995;75:874-885