Effects of three peptidase inhibitors, amastatin, captopril and phosphoramidon, on the hydrolysis of [Met5]-enkephalin-Arg6-Phe7 and other opioid peptides

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 3, 1998, Pages 276-282

  Hiranuma, Toyokazu ^a   Kitamura, Ken ^a   Taniguchi, Takao ^a   Kobayashi, Tomomi ^a   Tamaki, Raita ^a   Kanai, Masayuki ^a   Akahori, Kazuhito ^a   Iwao, Kayoko ^a   Oka, Tetsuo ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

Met5 enkephalin Arg6 Phe7 hydrolysis; Amastatin sensitive aminopeptidase; Captopril; Dipeptidyl carboxypeptidase I; Endopeptidase 24.11; High performance liquid chromatography; Opioid peptide hydrolysis; Phosphoramidon

Indexed keywords

AMASTATIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDORPHIN; OPIATE PEPTIDE; PHOSPHORAMIDON;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ILEUM; NONHUMAN; PROTEIN DEGRADATION; VAS DEFERENS;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTI-BACTERIAL AGENTS; CAPTOPRIL; ENKEPHALINS; GLYCOPEPTIDES; GUINEA PIGS; HYDROLYSIS; ILEUM; MALE; MEMBRANES; OPIOID PEPTIDES; PEPTIDES; PROTEASE INHIBITORS; VISUAL CORTEX;

EID: 0031940531     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005168     Document Type: Article

References (23)

1. Aoki K, Kajiwara M, Oka T (1984) The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileuin. Jpn J Pharmacol 36 : 59-65
2. 5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens. Jpn J Pharmacol 40: 297-302
3. 1-9 are ligands for the κ-subtype of opiate receptor. Nature 299 : 79-81
4. 5]-enkephalin in rat vas deferens. Jpn J Pharmacol 42 : 43-49
5. 3H]dopa in various regions of the brain. J Neurochem 13 : 655-669
6. Gulya K, Pelton JT, Hruby VJ, Yamamura HI (1986) Cyclic somatostatin octapeptide analogues with high affinity and selectivity toward mu opioid receptors. Life Sci 38 : 2221-2229
7. 61-64 possessing selective agonist activity at p-opiate receptors. Eur J Pharmacol 70 : 531-540
8. 5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan. Jpn J Pharmacol 41 : 437-446
9. s (Met-enk-RGL) hydrolysis in membrane preparations by the combination of amastatin, captopril and phosphoramidon. J Pharmacol Exp Ther 281 : 769-774
10. 2OH is a selective ligand for the μ-opiate binding site, Br J Pharmacol 73 : 299P
11. Kosterlitz HW, Watt AJ (1968) Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allyl-noroxymorphone (naloxone). Br J Pharmacol 33 : 266-276
12. Lord JAH. Waterfield AA. Hughes J, Kosterlitz HW (1977) Endogenous opioid peptides: multiple agonists and receptors. Nature 267 : 495-499
13. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193 : 265-275
14. Matsas R, Fulcher IS, Kenny AJ, Turner AJ (1983) Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli. Proc Natl Acad Sci USA 80 : 3111-3115
15. Matsas R, Stephenson SL, Hryszko J, Kenny AJ, Turner AJ (1985) The metabolism of neuropeptides. Biochem J 231 : 445-149
16. McKnight AT, Corbett AD, Kosterlitz HW (1983) Increase in potencies of opioid peptides after peptidase inhibition. Eur J Pharmacol 86 : 393-402
17. Morley JS (1980) Structure-activity relationships of enkephalinlike peptides. Annu Rev Pharmacol Toxicol 20 : 81-110
18. Numata H, Hiranuma T, Oka T (1988) Inactivation of dynorphin(1-8) in isolated preparations by three peptidases. Jpn J Pharmacol 47 : 417-423
19. Oka T, Negishi K, Suda M, Sawa A, Fujino M, Wakimasu M (1982) Evidence that dynorphin-(1-13) acts as an agonist on opioid κ-receptors. Eur J Pharmacol 77: 137-141
20. 5]-enkephalin in three isolated preparations: relative importance of aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A. In: Holaday JW, Law PY, Herz A (eds) NIDA Research Monograph 75: Progress in Opioid Research. U.S. Government Printing Office, Washington, DC, pp 259-262
21. Pelton JT, Kazmierski W, Gulya K, Yamamura HI. Hruby VJ (1986) Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J Med Chem 29 : 2370-2375
22. Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE (1988) Binaltorphimine-related bivalent ligands and their K opioid receptor antagonist selectivity. J Med Chem 31 : 836-841
23. Rubin B, Laffan RJ, Kotler DG, O'Keefe EH, Demaio DA, Goldberg ME (1978) SQ 14,225 (D-3-mereapto-2-methyl proparoyl-L-proline), a novel orally active inhibitor of angiotensin I converting enzymes. J Pharmacol Exp Ther 204 : 271-280