Postperfusion energy metabolism of steatotic graft and its relation to early graft viability following liver transplantation

Digestive Diseases and Sciences

Volumn 43, Issue 1, 1998, Pages 74-79

  Miki, Chikao ^a   Iriyama, Keiji ^b   Mirza, Darius F ^b   Mayer, A David ^b   Buckels, John A C ^b   Suzuki, Hiroshi ^b   McMaster, Paul ^b  

^a MIE UNIVERSITY   (Japan)

^b NONE

Author keywords

Energy metabolism; Graft; Liver transplantation; Steatosis

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CARNITINE; FATTY ACID; GLUCOSE; HYALURONIC ACID; LACTIC ACID; PYRUVIC ACID; SCATTER FACTOR; TRIACYLGLYCEROL;

ARTICLE; BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; FATTY ACID OXIDATION; FATTY LIVER; FEMALE; GLUCOSE OXIDATION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; KETOGENESIS; LIVER METABOLISM; LIVER PERFUSION; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; PROTHROMBIN TIME;

EID: 0031940462     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018824004318     Document Type: Article

References (38)

1. Portmann B, Wight DGD: Pathology of liver transplantation (excluding rejection) In Liver Transplantation: The Cambridge and King's College Hospital Experience. R Calne, (ed). Orlando, Florida: Grune & Stratton, 1987, 437 pp
2. Todo S, Demetris AJ, Makowka L, Teperman L, Podesta L, Shaver T, Tzakis A, Starzl TE: Primary nonfunction of hepatic allografts with preexisting fatty infiltration. Transplantation 47:903-905, 1989
3. Adam R, Reynes M, Johann M, Morino M, Astarcioglu I, Kafetzis I, Castaing D, Bismuth H: The outcome of steatotic grafts in liver transplantation. Transplant Proc 23:1538-1540, 1991
4. Gao W, Conner HD, Lemasters JJ, Mason RP, Thurman RG: Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species. Transplantation 59:674-679, 1995
5. Takada Y, Ozawa K, Yamaoka Y, Uemoto S, Tanaka A, Morimoto T, Honda K, Shimahara Y, Mori K, Inamoto T.: Arterial ketone body ratio and glucose administration as an energy substrate in relation to changes in ketone body concentration after living-related liver transplantation in children. Transplantation 55:1314-1319, 1993
6. Blomstrand R, Kager L, Lantto O: Studies on the ethanol induced decrease of fatty acid oxidation in rat and human liver slices. Life Sci 13:1131-1135, 1973
7. Scheig R: Lipid synthesis from ethanol in the liver. Gastroenterology 60:751-756, 1971
8. Teramoto K, Bowers JL, Khetty U, Palombo JD, Clause ME: A rat fatty liver transplant model. Transplantation 55:737-741, 1993
9. Bernal CA, Vazques JA, Adibi SA: Liver triglyceride concentration and body protein metabolism in ethanol-treated rats: Effect of energy and nutrient supplementation. Gastroenterology 103:289-295, 1992
10. Laurell S: A method for routine determination of plasma triglycerides. Scand J Clin Lab Invest 18:668-672, 1966
11. Tsubouchi H, Niitani Y, Hirono S, Nakayama H, Gohda E, Arakaki N, Sakiyama O, Takahashi K, Kimoto M, Kawakami S: Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay. Hepatology 13:1-5, 1991
12. Karayalcin K, Harrison JD, Attard A, Gunson BK, Jones S, Mayer D, Buckels JA, McMaster P: Can effluent hyaluronic acid or creatine kinase predict sinusodial injury severity after cold ischemia? Transplantation 56:1336-1339, 1993
13. Asonuma K, Takaya S, Selby R, Okamoto R, Yamamoto Y, Yokoyama Y, Todo S, Starzl TE: The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation. Transplantation 51:164-171, 1991
14. Cederblad G, Lindstedt S: A method for the determination of carnitine in the picomole range. Clin Chim Acta 37:235-243, 1972
15. Hornboll P, Olsen TS: Fatty changes in the liver: The relation to age, overweight and diabetes mellitus. Acta Pathol Microbiol Immunol Scand (A) 90:199-206, 1982
16. Hilden M, Christoffersen P, Juhl E, Dalgaard JB: Liver histology in a normal population - examination of 503 consecutive fatal traffic casualties. Scand J Gastroenterol 12:593-605, 1977
17. Underwood Ground KE: Prevalence of fatty liver in healthy male adults accidentally killed. Aviat Space Environ Med 55:59-63, 1984
18. D'Alessadro AM, Kalayoglu M, Sollinger HW, Hoffmann RM, Reed A, Knechtle SJ, Pirsch JD, Hafez GR, Lorentzen D, Belzer FO: The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation. Transplantation 51:157-163, 1991
19. D'Alessandro AM, Kalayoglu M, Sollinger HW, Hoffmann RM, Reed A, Knechtle SJ, Pirsch JD, Hafez GR, Lorentzen D, Belzer FO: The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation. Trans Proc 23:1536-1537, 1991
20. Avolio AW, Agnes S, Pelosi G, Sollazzi L, Magalini SC, Gozzo ML, Castagneto M: Intraoperative trends of oxygen consumption and blood lactate as predictors of primary dysfunction after liver transplantation. Transplant Proc 23:2263-2265, 1991
21. Ozaki N, Ringe B, Gubernatis G, Takada Y, Yamaguchi T, Yamaoka Y, Oellerich M, Ozawa K, Pichlmayr R: Changes in energy substrates in relation to arterial ketone body ratio after human orthotopic liver transplantation. Surgery 113:403-409, 1993
22. Persson H, Karlberg I, Svensson K, Stenquist O, Lundholm K, Andersson C, Frisk B, Hedman L, Brynger H, Schersten T: Rapid indication of allograft function in liver transplantation. Transplant Proc 19:3545-3548, 1987
23. Fath J, Ascher N, Konstantinides F, Bloomer J, Sharp H, Najarian JS, Cerra FB: Metabolism during hepatic transplantation: Indicators of allograft function. Surgery 96:664-673, 1984
24. Rebouche CE, Engel AG: Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. J Clin Invest 73:857-867, 1984
25. Brooks DE, McIntosh JEA: Turnover of carnitine by rat tissue. Biochem J 148:439-445, 1975
26. Bohles HJ, Akcetin Z: Ketogenic effects of low and high levels of carnitine during total parenteral nutrition in the rat. Am J Clin Nutr 46:47-51, 1987
27. O'Connor JE, Costell M, Miguez MP, Portoles M, Grisolia S: Effect of L-carnitine on ketone bodies, redox state and free amino acids in the liver of hyperammonemic mice. Biochem Pharmacol 36:3169-3173, 1987
28. Lai HS, Chen WJ: Alterations of remnant liver carnitine palmitoyltransferase I activity and serum carnitine concentration after partial hepatectomy in rats. J Surg Res 59:754-758, 1995
29. Miki C, Iriyama K, Harrison JD, Gunson BK, D'Silva M, Suzuki H, McMaster P: Glycogen content of the donor liver and its relation to postreperfusion hepatic energy metabolism. Am J Gastroenterol (in press)
30. Stanley CA: New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency. Adv Pediatr 34:59-88, 1987
31. Schmidt-Sommerfeld E, Penn D, Kerner J, Bieber LL, Rossi TM, Lebenthal E: Quantitation of urinary carnitine esters in a patient with medium-chain acyl-coenzyme dehydrogenase deficiency: Effect of metabolic state and L-carnitine therapy. J Pediatr 115:577-582, 1989
32. Sandor A, Cseko J, Kispal G, Alkonyi I: Surplus acylcarnitines in the plasma of starved rats derive from the liver. J Biol Chem 265:22313-22316, 1990
33. Miki C, Iriyama K, Strain A, Harrison JD, Hirono S, Gunson BK, Sherewell JM, Suzuki H, McMaster P: The clinical significance of serum hepatocyte growth factor in orthotopic liver transplantation. Surgery 119:505-510, 1996
34. Itasaka H, Kishikawa K, Suehiro T, Yanaga K, Shimada M, Higashi H, Kakizoe S, Ikeda T, Wakiyama S, Sugimachi K: Serum hyaluronic acid for the assessment of graft viability in porcine liver transplantation. Surg Today 24:719-724, 1994
35. Shimizu H, He W, Guo P, Dziadkoviec I, Miyazaki M, Falk RE: Serum hyaluronate in the assessment of liver endothelial cell function after orthotopic liver transplantation in the rat. Hepatology 20:1323-1329, 1994
36. Suehiro T, Boros P, Curtiss S, Mor E, Emre S, Sheiner P, Schwartz ME, Miller CM: Perioperative hyaluronic acid levels in orthotopic liver transplantation recipient. Transplant Proc 27:1261, 1995
37. Bronsther OL, Rao PN, Pinna A, Snyder J, Cowan S, Kramer D, Takaya S, Starzl TE: Effluent levels of hyaluronic acid can predict ultimate graft outcome after clinical liver transplantation: A prospective series. Transplant Proc 25:1538-1540, 1993
38. Rao PN, Bronsther OL, Pinna AD, Demetris A, Snyder J, Fung J, Starzl TE: Prediction of early graft function by effluent levels of hyaluronic acid in clinical liver transplantation. Transplant Proc 25:2141-2142, 1993