Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis

Diabetes

Volumn 47, Issue 2, 1998, Pages 179-185

  Stevenson, Ralph W ^a   Kreutter, David K ^a   Andrews, Kim M ^a   Genereux, Paul E ^a   Gibbs, E Michael ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; ENGLITAZONE; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LONG CHAIN FATTY ACID COENZYME A LIGASE; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE P60;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GLUCOSE TRANSPORT; INSULIN RELEASE; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031939586     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.2.179     Document Type: Article

References (27)

1. Okada T, Kawano Y, Sakakibara T, Hazeko O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilypolysis in rat adipocytes. J Biol Chem 269:3568-3573, 1994
2. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911, 1994
3. Gould GW, Jess TJ, Andrews GC, Herbst JJ, Plevin RJ, Gibbs EM: Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes. J Biol Chem 269:26622-26625, 1994
4. Sun XJ, Rothernberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77, 1991
5. Lamphere M, Carpenter CL, Sheng Z, Kallen RG, Lienhard GE: Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1. Am J Physiol 266:E486-E489, 1994
6. Herbst JJ, Andrews G, Contillo L, Lamphere L, Gardner J, Lienhard GE, Gibbs EM: Potent activation of phosphatidylinositol 3′-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains. Biochemistry 33:9376-9381, 1994
7. Herbst JJ, Andrews GC, Contillo LG, Singleton DH, Genereux PE, Gibbs EM, Lienhard GE: Effect of the activation of phosphatidylinositol 3-kinase by thiophosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes. J Biol Chem 270:26000-26005, 1995
8. Le Marchand-Brustel Y, Gautier N, Cormont M, Van Obberghen E: Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. Endocrinology 136:3564-3570, 1995
9. Stevenson RW, Gibbs EM, Kreutter DK, McPherson RK, Clark DA, Hulin B, Goldstein SW, Parker JC, Swick AG, Treadway JL, Hargrove DM, Shulman GI: The thiazolidinedione drug series. In Diabetes Annual. 9th ed. Marshall SM, Home PD, Rizza RA, Eds. Amsterdam, Netherlands, Elsevier Science, 1995, p. 175-191
10. Stevenson RW, Hutson NJ, Krupp MN, Volkmann, RA, Holland GF, Eggler JF, Clark DA, McPherson RK, Hall KL, Danbury BH, Gibbs EM, Kreutter DK: Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice. Diabetes 39:1218-1227, 1990
11. Kreutter DK, Andrews KM, Gibbs EM, Hutson NJ, Stevenson RW: Insulinlike activity of new antidiabetic agent CP 68722 in 3T3-L1 adipocytes. Diabetes 39:414-419, 1990
12. Gibbs EM, Genereux PE, Kreutter DK, Andrews KM, Stevenson RW: A novel antidiabetic agent, CP-68,722, increases levels of glucose transport and glucose transporter protein in 3T3-L1 adipocytes (Abstract). Diabetologia 32:491A, 1989
13. Stevenson RW, Danbury BM, Earle KA Actions of the antihyperglycemic agent englitazone on lipid and cholesterol metabolism. Diabetes 41 (Suppl. 1):18A, 1992
14. Zhang B, Szalkowski D, Diaz E, Hayes N, Smith R, Berger J: Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes. J Biol Chem 269:25735-25741, 1994
15. Cuendet GS, Loten EG, Jeanrenaud B, Renold AE: Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice. J Clin Invest 58:1078-1088, 1976
16. Lavan BE, Lane WS, Lienhard GE: The 60 kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 272:11439-11443, 1997
17. Stevenson RW, Gibbs EM, Parker JC, Shulman GI, Kessedjian M-J, Reynolds JA, Kreutter DK: Thiazolidinedione antidiabetics. In Lessons From Animal Diabetes. 5th ed. Shafrir E, Ed. London, U.K., Smith-Gordon, 1995, p. 181-195
18. Stevenson RW, McPherson RK, Genereux PE, Danbury BH, Kreutter DK: Anti-diabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia. Metabolism 40:1268-1274, 1991
19. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR-γ). J Biol Chem 270:12953-12956, 1995
20. Schoonjans K, Staels B, Auwerx J: The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302:93-109, 1996
21. Willson TM, Cobb JE, Cowan DJ, Wiethe RW, Correa ID, Prakash SR, Beck KD, Moore LB, Kliewer SA, Lehmann JM: The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39:665-668, 1996
22. Gibbs EM, Banker MJ, McCoid SC, Genereux PE, Pereira DA: Differential regulation of GLUT 1 and GLUT 4 mRNA by the antidiabetic agent englitazone. Diabetes 41 (Suppl. 1):202A, 1992
23. Araki E, Lipes MA, Patti M-E, Bruning JC, Haag BIII, Johnson RS, Kahn CR: Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190, 1994
24. Yang J, Clarke JF, Ester CJ, Young PW, Kasuga M, Holman GD: Phosphatidylinositol 3-kinase acts at an intracellular site to enhance GLUT4 exocytosis in 3T3-L1 cells. Biochem J 313:125-131, 1996
25. McPherson RK, Gibbs EM, Treadway JL, Stevenson RW: Englitazone effects on signal transduction and metabolic responses to insulin and glucagon in isolated rat hepatocytes. Diabetes 42 (Suppl. 1):36A, 1993
26. Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I, Totty NF, Truong O, Vicendo P, Yonezawa K, Kasuga M, Courtneidge SA, Waterfield MD: PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J 13:522-533, 1994
27. Suga J, Yoshimasa Y, Yamada K, Yamamoto Y, Inoue G, Okamoto M, Hayashi T, Shigemoto M, Kosaki A, Kuzuya H, Nakao K: Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes: a possible involvement of PI 3-kinase in the activation of the MAP kinase by insulin. Diabetes 46:735-741, 1997