Further insights into the anti-aggregating activity of NMDA in human platelets

British Journal of Pharmacology

Volumn 124, Issue 1, 1998, Pages 35-40

  Franconi, Flavia ^c   Miceli, Mauro ^b   Alberti, Luisa ^c   Seghieri, Giuseppe ^b   De Montis, M Graziella ^a   Tagliamonte, Alessandro ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

Author keywords

Ca2+ (i); Aggregation; Arachidonic acid; Glutamate; NMDA receptors; Platelets; Thromboxane

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLSALICYLIC ACID; CALCIUM ION; FURA 2 ACETOXYMETHYL ESTER; INDOMETACIN; N METHYL DEXTRO ASPARTIC ACID; N(G) METHYLARGININE; THROMBOXANE B2;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

ASPIRIN; BLOOD PLATELETS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDOMETHACIN; N-METHYLASPARTATE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PLATELET AGGREGATION INHIBITORS; THROMBOXANE B2;

EID: 0031939178     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701790     Document Type: Article

References (34)

1. AAS, P., TANSO, R. & FONNUM, K. (1989). Stimulation of peripheral cholinergic nerves by glutamate indicates a new peripheral glutamate receptor. Eur. J. Pharmacol., 164, 93-102.
2. ABBRACCHIO, M.P. & BURNSTOCK, C. (1994). Purinoreceptors: are there three families of P2x and P2y purinoreceptors? Pharmacol. Ther., 64, 445-475.
3. BERTRAND, G., GROSS, R., PEUCH, R., LOUBATIÈRES-MARIANI, M.M. & BOCKAERT, J. (1992). Evidence for a glutamate receptor of AMPA subtype which mediates insuline release from rat perfused pancreas. Br. J. Pharmacol., 106, 364-369.
4. BERTRAND, G., GROSS, R., PEUCH, R., LOUBATIÈRES-MARIANI, M.M. & BOCKAERT, J. (1993). Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas. Eur. J. Pharmacol., 237, 45-50.
5. BORN, G.U.R. & CROSS, M.J. (1963). The aggregation of blood platelets. J. Physiol., 168, 178-186.
6. BREDT, D.S. & SNYDER, S.H. (1989). Nitric oxide mediates glutamate linked enhancement of cGMP levels in cerebellum. Proc. Natl. Acad. Sci. U.S.A., 86, 9030-9033.
7. DURANTE, W. KROLL, M.H, VANHOUTTE, P.M. & SCHAFER, A.I.(1992). Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C. Blood, 79, 110 116.
8. ERDO, S.L. (1991). Excitatory amino acid receptors in the mammalian periphery. Trends Pharmacol Sci. 12, 426-429.
9. FORSTERMANN, U., SCHMIDT, H.H., POLLOCK, J.S., SHENG, H. MITCHELL, J.A., WARNER, T.D., NAKANE, M. & MURAD, F. (1991). Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem. Pharmacol., 42, 1849-1857.
10. FOSTER, A.C. & WONG, H.F. (1987). The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain. Br. J. Pharmacol., 91, 403-409.
11. FRANCONI, F., BENNARDINI, F., MATTANA, A., MICELI, M., CIUTI, M., MIAN, M., GRONI, A., ANNICHINI, R. & SEGHIERI, G. (1995). Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effect of taurine supplementation. Am. J. Clin. Nutr., 61, 1115-1119.
12. FRANCONI, F., MICELI, M., DEMONTIS, M.G., LUPIS CRISAFI, E., BENNARDINI, F. & TAGLIAMONTE, A. (1996). NMDA receptors play an anti-aggregating role in human platelets. Thromb. Haemost., 76, 84-87.
13. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3451.
14. 2 action on platelets and blood vessels. Platelets. 2, 69 76.
15. HAWIGER, J., PARKISON, S. & TIMMONS, S. (1980). Prostacyclin inhibits mobilization of fibrinogen binding sites on human ADP and thrombin-treated platelets. Nature, 283, 195 197.
16. INSEL, P.A. (1995). Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In Goodman & Gilman's The Pharmacological Basis of Therapeutics. ed. Hardman, J.G. & Limbird, L.I. pp. 617-657 New York: McGraw-Hill.
17. 2+ and on aggregation of human platelets. Eur. J. Pharmacol., 244, 37-47.
18. KEMP, J.A. & LEESON, P.D. (1993). The glycine site of the NMDA receptor-five years on-. Trends Pharmacol. Sci., 14, 20-25.
19. LUZZI, S., ZILLETTI, L., FRANCHI-MICHELI, S. GORI, A.M. & MORONI, F. (1988). Agonists, antagonists and modulators of excitatory amino acid receptors in the guinea-pig myenteric plexus. Br. J. Pharmacol., 95, 1271-1277.
20. MFLLION, B.T., IGNARRO, J., OHLSTEIN, E.H., PONTECORVO, E.G., HAYMAN, A.L. & KADOWITZ, P.J. (1981). Evidence for inhibitory role of guanosine 3′, 5′ monophosphate in ADP induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood, 57, 946-955.
21. METHA, J.L., CHEN, L., METHA, P., KONE, B.C. & TURNER, P. (1995). Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J. Lab. Clin. Med., 125, 370-377.
22. MORONI, F., LUZZI, S., FRANCHI-MICHELI, S. & ZILLETTI, L. (1986). The presence of N-Methyl-D-Aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus. Neurosci. Lett., 68, 57-62.
23. PANNOCCHIA, A. & HARDISTY, R.M. (1985). Cyclic AMP inhibits platelet activtion independently of its effect on cytosolic free calcium. Biochem. Biophys. Res. Commun., 127, 339 345.
24. PRESCOTT, S.M. & MAJERUS, P.W. (1983). Characterization of 1,2-diacylglycerl hydrolysis in human platelets. Demonstration of an arachidonyl-monoacylglycerol intermediate. J. Biol. Chem. 258, 764 769.
25. RADOMSKI, M.D., PALMER, R.M.J. & MONCADA, S. (1990). Characterization of the L-arginine: nitric oxide pathway in human platelets. Br. J. Pharmacol., 101, 325 328.
26. SCHUMAN, E.M. & MADISON, D.V. (1994). Nitric oxide and synaptic function. Annu. Rev. Neurosci., 17, 153-183.
27. SIESS, W. (1898). Molecular mechanism of platelet activation. Physiol. Rev., 69, 58-178.
28. TAN, C.H., LEE, H.S., KUA, E.H. & PEH, L.H. (1995). Resting and thromhin-stimulated cytosolic calcium in platelets of patients with alcoholic withdrawal, bipolar manic disorders and chronic schizophrenia. Life Sci., 21, 1817-1823.
29. TSUNODA, Y., MATSUNO, K. & TASHIRO, Y. (1988). Spatial distribution and temporal change of cytoplasmic free calcium in human platelets. Biochem. Biophvs. Res. Commun., 156, 1152-1159.
30. VILLABOS, C., NUNEZ, L. & GARCIA-SANCHO, J. (1996). Functional glutamate receptors in a subpopulation of anterior pituitary cells. FASEB J., 10, 654 660.
31. 2 in human platelet rich plasma. J. Biol. Chem., 257, 14847 14853.
32. WINTER, C.R. & BAKER, R.C. (1995). L-Glutamate-induced changes in extracellular calcium oscillation frequency through non classical glutamate receptor binding in cultured rat myocardial cells. Life Sci., 57, 1925 1934.
33. WONG, E.H.F., KEMP, J.A., PRISTLEY, T., KNIGHT, A.R., WOODRUFF, G.N. & IVERSEN, L.L. (1986). The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Natl. Acad. Sci. U.S.A., 83, 7104-7108.
34. 3H]glutamate binding sites in rat adrenal medulla. Brain Res., 383, 387-391.