Influence of protein binding on the pharmacodynamics of ceftazidime or ceftriaxone against Gram-Positive and Gram-Negative bacteria in an in vitro infection model

Journal of Chemotherapy

Volumn 10, Issue 1, 1998, Pages 29-34

  Scaglione, F ^a   Demartini, G ^a   Arcidiacono, M M ^a   Dugnani, S ^a   Fraschini, F ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Ceftazidime; Ceftriaxone; Pharmacokinetics

Indexed keywords

CEFTAZIDIME; CEFTRIAXONE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATION; COLONY FORMING UNIT; COMPUTER SIMULATION; DRUG DETERMINATION; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INTENSIVE CARE; INTRAMUSCULAR DRUG ADMINISTRATION; MINIMUM INHIBITORY CONCENTRATION; PHARMACODYNAMICS; PLASMA PROTEIN BINDING; PNEUMONIA; PSEUDOMONAS AERUGINOSA; STREPTOCOCCUS PNEUMONIAE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0031937966     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.1998.10.1.29     Document Type: Article

References (19)

1. Rolinson GN. The significance of protein binding of antibiotics in antibacterial chemotherapy. J Antimicrob Chemother 1980; 6: 311-317.
2. Wise R. Protein binding of β-lactams: the effects on activity and pharmacology particularly tissue penetration I. J Antimicrob Chemother 1983; 12: 1-18.
3. Wise R. Protein binding of β-lactams: the effects on activity and pharmacology particularly tissue penetration II. J Antimicrob Chemother 1983; 12: 105-118.
4. Wise R. The clinical relevance of protein binding and tissue concentrations in antimicrobial therapy. Clin Pharmacokin 1986; 11: 40-482.
5. Craig WA, Welling PG, Protein binding and antimicrobials: clinical pharmacokinetics and therapeutic implications. Clin Pharmacokin 1987; 9: 252-268.
6. Drusano GL. Role of pharmacokinetics in outcome of infections. Antimicrob Agents Chemother 1988; 32: 289-297.
7. Scaglione F, Demartini G, Dugnani S, Fraschini F. A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. Chemotherapy 1990; 34: 1056-1060.
8. Rains CP, Bryson HM, Peters DH. Ceftazidime: an update of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1995; 49(4): 577-617).
9. Patel IH, Chen S, Parsonnet M, et al. Pharmacokinetics of ceftriaxone in humans. Antimicrob Agents Chemother 1981; 20: 634-641.
10. Scaglione F, Dugnani S, Demartini G, Arcidiacono MM, Cocuzza CE, Fraschini F. Bactericidal kinetics of an in vitro infection model of once-daily ceftriaxone plus amikacin against Gram-positive and Gram-negative bacteria. Chemotherapy 1995; 41: 239-246.
11. National Committee for Clinical Laboratory Standards. Approved standard M7-A. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. National Committee for Clinical Laboratory Standards, Villanova, Pa. 1990.
12. Chan CY, French GL. Rapid high performance liquid chromatography assay of cephalosporins in biological fluids. J Antimicrob Chemother 1986; 18: 537-545.
13. Merrikin DJ, Briant J, Rolinson GN. Effect of protein binding on antibiotic activity in vivo. J Antimicrob Chemother 1983; 11: 233-238.
14. Bakker-Woundenberg IAIM, Van Den Berg JC, Vree TB, Baars AM, Michel MF. Relevance of serum protein binding of cefoxitin and cefazolin to their activities against Klebsiella pneumoniae pneumonia in rats. Antimicrob Agents Chemother 1985; 28: 654-659.
15. Gerding DNL, Van Etta LL, Peterson LR. Role of serum protein binding and multiple antibiotic doses in the extravascular distribution of ceftizoxime and cefotaxime. Antimicrob Agents Chemother 1982; 22: 844-847.
16. Van Etta LL, Kravitz GR, Russ TE, Fasching CE, Gerding DN, Peterson LR. Effect of method of administration on extravascular penetration of four antibiotics. Antimicrob Agents Chemother 1982; 21: 873-880.
17. Peterson LR, Van Etta LL, Fasching CE, Gerding DN. Effect of protein binding on simulated intravascular and extravascular kinetics of cefotaxime in an in vitro model. Antimicrob Agents Chemother 1984; 25: 58-61.
18. Tawara S, Matsumoto S, Kamimura T, Goto S. Effect of protein binding in serum on therapeutic efficacy of cephem antibiotics. Antimicrob Agents Chemother 1992; 36: 17-24.
19. Wiedemann B, Atkinson BA. Susceptibility to antibiotics: species incidence and trends. In: Antibiotics in Laboratory Medicine, V. Lorian, ed. Baltimore, MD: Williams & Wilkins 1991; 962-1062.