Growth hormone secretion elicited by GHRH, GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapy

Clinical Endocrinology

Volumn 48, Issue 1, 1998, Pages 103-108

  Popovic, V ^a   Simic, M ^a   Ilic, Lj ^a   Micic, D ^a   Damjanovic, S ^a   Djurovic, M ^a   Obradovic, S ^a   Dieguez, C ^b   Casanueva, F ^c  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c Endocrine Area   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; GROWTH HORMONE RELEASING FACTOR;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DATA ANALYSIS; DOSE RESPONSE; DRUG EFFECT; FEMALE; GROWTH HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNE RESPONSE; MALE; MOLECULAR CLONING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROLACTIN RELEASE; PROLACTINOMA;

EID: 0031936844     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00360.x     Document Type: Article

References (19)

1. Bowers, C., Momany, F., Reynolds, G. & Hong, A. (1984) On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology, 114, 1537-1545.
2. Bowers, C., Reynolds, G., Durham, D., Barrera, C. & Thorner, M. (1990) Growth hormone releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. Journal of Clinical Endocrinology and Metabolism, 70, 975-982.
3. Bowers, C. (1993) Novel GH releasing peptides. In Molecular and Clinical Advances in Pituitary Disorders (ed. S. Melmed), pp. 153-158. Endocrine Research and Education Inc, Los Angeles.
4. 2 on growth hormone (GH-releasing factor stimulated GH) release and intracellular adenosine 3,5-monophosphate accumulation in rat pituitary cell culture. Endocrinology, 124, 2791-2798.
5. Ciccarelli, E., Grotolli, S., Gianotti, E., Camanni, G. & Ghigo, E. (1996) Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinemic patients. Clinical Endocrinology, 44, 67-71.
6. Codd, E., Shu, A. & Walker, R. (1989) Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites. Neuropharmacology, 28, 1139-1141.
7. Dickinson, S.L., Leng, G. & Robinson, I.A.C. (1993) Systemic administration of growth hormone releasing peptide activates hypothalamic arcuate neurons. Neuroscience, 53, 303-306.
8. Ghigo, E., Arvat, E., Gianotti, L., Imbibo, P. & Camanni, F. (1994) Growth hormone releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal and oral administration in man. Journal of Clinical Endocrinology and Metabolism, 78, 693-698.
9. Hartman, M., Farello, G., Pezzoli, S. & Thorner, M. (1992) Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. Journal of Clinical Endocrinology and Metabolism, 74, 1378-1384.
10. Ilson, B., Jorkasky, D., Curnow, R. & Sote, R. (1989) Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy subjects. Journal of Clinical Endocrinology and Metabolism, 69, 212-214.
11. Jaffe, C., Demott-Friberg, R., Bowers, C. & Barkan, A. (1993) Effects of prolonged growth hormone releasing peptide infusion on pulsatile GH secretion in normal man. Journal of Clinical Endocrinology and Metabolism, 77, 1641-1647.
12. 2 (GHRP-6) induced GH secretion in the rat. Neuroendocrinology, 57, 247-256.
13. Micic, D., Popovic, V., Kedereski, A., Macut, Dj., Casanueva, F. & Dieguez, C. (1995) Growth hormone secretion after administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood. Clinical Endocrinology, 42, 191-194.
14. Penalva, A., Carballo, A., Pombo, M., Casanueva, F. & Dieguez, C. (1993) Effect of growth hormone releasing hormone (GHRH), atropine, pyridostigmine or hypoglycaemia on GHRP-6 induced GH secretion in man. Journal of Clinical Endocrinology and Metabolism, 76, 168-171.
15. Pombo, M., Barreiro, J., Penalva, A., Peino, R., Dieguez, C. & Casaneuva, F. (1995) Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6) or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection. Journal of Clinical Endocrinology and Metabolism, 80, 3180-3184.
16. Popovic, V., Damjanovic, S., Micic, D., Djurovic, M., Dieguez, C. & Casanueva, F. (1995) Blocked growth hormone releasing peptide (GHRP-6) induced GH secretion and absence of the synergic action of GHRP-6 plus GHRH hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is excreted at the hypothalamic level. Journal of Clinical Endocrinology and Metabolism, 80, 942-947.
17. Robinson, I.A.C.F. (1996) Mechanism of action of GHRPs in vivo. Abstract S 10-2 In Tenth International Congress of Endocrinology, San Fransisco, USA. Program and Abstracts, p.26.
18. Smith, R. (1996) Modulation of pulsatile growth hormone release by an orally active growth hormone secretagogue. Abstract S 10-1, In Tenth International Congress of Endocrinology, San Franscisco, USA. Program and Abstracts, USA, p.26.
19. Toogood, A., Nass, R., Pezzoli, S., O'Neill, P., Thorner, M. & Shalet, S. (1997) Sensitive assay reveals pulsatile GH secretion despite a 90% reduction in GH release. Abstract 037, Endocrinology and Metabolism, 4, (Suppl A), 23.